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CAS No. : | 399-52-0 |
Formula : | C8H6FN |
M.W : | 135.14 |
SMILES Code : | FC1=CC2=C(NC=C2)C=C1 |
MDL No. : | MFCD00005671 |
InChI Key : | ODFFPRGJZRXNHZ-UHFFFAOYSA-N |
Pubchem ID : | 67861 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
89% | With zinc(II) chloride In acetonitrile at 85℃; for 24.1667 h; | Alternatively, a mixture of 5-fluoroindole (5.00 g, 5.00 g, 35.5 mmol, 96 mass percent, 1.00) and maleimide (1.5 equiv., 5.17 g, 53.3 mmol, 1.50) was charged in a 50 mL vessel, and then acetonitrile (3 L/kg, 15.0 mL, 1 1.7 g, 286 mmol, 100 mass percent) and zinc chloride (1.05 equiv., 5.08 g, 37.3 mmol, 100 mass percent) were added. The reaction was heated to 85°C over 10 min and then maintained at 85°C for 24 hrs. While still at 85 °C, water (6 L/kg, 30.0 mL, 30.0 g, 1670 mmol, 100 mass percent) was added slowly, while maintaining the temperature above 80°C. Yellow solids precipitated. The reaction mixture was cooled to 50°C over 1 hour followed by stirring at 50°C for 2 hours, then cooled 10°C over 1 hour. The reaction was stirred at 10°C for 1 hour. The solids were filtered off, then the filter cake was washed 2 times with 5 ml 1 :1 ACN/water to afford isolated compound (6.85 g, 6.85 g, 29.5 mmol, 83.1 percent Yield). For purification, the resulting isolated compound was charged (6.85 g, 6.85 g, 29.5 mmol, 100 mass percent) into a vessel, followed by addition of tetrahydrofuran (6 L/kg, 41.1 mL, 36.4 g, 505 mmol, 100 mass percent). This mixture was heated to 66°C to form a homogeneous solution. Heptane (4 L/kg, 27.4 mL, 18.7 g, 187 mmol, 100 mass percent, was added slowly at 66°C ; solids began to precipitate after 5 volumes. The mixture was cooled to 25°C over 3 hours, then filtered and washed with heptane, followed by drying in the high vacuum oven overnight. Isolated compound (4.93 g, 4.93 g, 21.2 mmol, 100 mass percent, 72.0percent Yield). This isolated compound is charged 2 (1.00 g, 4.3 mmol, 100 mass percent,) into a 50ml vessel and tetrahydrofuran (6 L/kg, 6 mL, 100 mass percent) and heptane (6 L/kg, 6 mL, 100 mass percent) were added. The slurry was stirred at 25°C for 48 hrs. The solids were filtered off and dried in the high vacuum oven overnight. The Isolated compound : (0.89 g, 3.83 mmol, 100 mass percent, 89.00percent Yield). |
83.1% | With zinc(II) chloride In acetonitrile at 85℃; for 24 h; | Route B: (0356) Alternatively, a mixture of 5-Fluoroindole (5.00 g, 5.00 g, 35.5 mmol, 96 mass percent, 1.00) and Maleimide (1.5 equiv., 5.17 g, 53.3 mmol, 1.50) was charged in a 50 mL vessel, and then Acetonitrile (3 L/kg, 15.0 mL, 11.7 g, 286 mmol, 100 mass percent) and Zinc Chloride (1.05 equiv., 5.08 g, 37.3 mmol, 100 mass percent) were added. The reaction was heated to 85° C. over 10 min and then maintained at 85° C. for 24 hrs. While still at 85° C., Water (6 L/kg, 30.0 mL, 30.0 g, 1670 mmol, 100 mass percent) was added slowly, while maintaining the temperature above 80° C. Yellow solids precipitated. The reaction mixture was cooled to 50° C. over 1 hour followed by stirring at 50° C. for 2 hours, then cooled 10° C. over 1 hour. The reaction was stirred at 10° C. for 1 hour. The solids were filtered off, then the filter cake was washed 2 times with 5 ml 1:1 ACN/water to afford isolated compound (6.85 g, 6.85 g, 29.5 mmol, 83.1percent Yield). (0357) For purification, the resulting isolated compound was charged (6.85 g, 6.85 g, 29.5 mmol, 100 mass percent) into a vessel, followed by addition of Tetrahydrofuran (6 L/kg, 41.1 mL, 36.4 g, 505 mmol, 100 mass percent). This mixture was heated to 66° C. to form a homogeneous solution. Heptane (4 L/kg, 27.4 mL, 18.7 g, 187 mmol, 100 mass percent, was added slowly at 66° C.; solids began to precipitate after 5 volumes. The mixture was cooled to 25° C. over 3 hours, then filtered and washed with heptane, followed by drying in the high vacuum oven overnight. Isolated compound (4.93 g, 4.93 g, 21.2 mmol, 100 mass percent, 72.0percent Yield). (0358) This isolated compound is charged 2 (1.00 g, 4.3 mmol, 100 mass percent) into a 50 ml vessel And Tetrahydrofuran (6 L/kg, 6 mL, 100 mass percent) and Heptane (6 L/kg, 6 mL, 100 mass percent) were added. The slurry was stirred at 25° C. for 48 hrs. The solids were filtered off and dried in the high vacuum oven overnight. The Isolated compound: (0.89 g, 0.89 g, 3.83 mmol, 100 mass percent, 89.00percent Yield). |
83.1% | Stage #1: With zinc(II) chloride In acetonitrile at 85℃; for 24 h; Microwave irradiation Stage #2: at 10 - 80℃; for 4 h; |
Alternatively, a mixture of 5-Fluoroindole (5.00 g, 5.00 g, 35.5 mmol, 96 mass percent, 1.00) and Maleimide (1.5 equiv., 5.17 g, 53.3 mmol, 1.50) was charged in a 50 mL vessel, and then Acetonitrile (3 LIkg, 15.0 mL, 11.7 g, 286 mmol, 100 mass percent) and Zinc Chloride (1.05 equiv., 5.08 g, 37.3 mmol, 100 mass percent) were added. The reaction washeated to 85°C over 10 mm and then maintained at 85°C for 24 hrs. While still at 85°C, Water (6 L/kg, 30.0 mL, 30.0 g, 1670 mmol, 100 mass percent) was added slowly, while maintaining the temperature above 80°C. Yellow solids precipitated. The reaction mixture was cooled to 50°C over 1 hour followed by stirring at 50°C for 2 hours, then cooled 10°C over 1 hour. The reaction was stirred at 10°C for 1 hour. The solids werefiltered off, then the filter cake was washed 2 times with 5 ml 1:1 ACN/water to afford isolated compound (6.85 g, 6.85 g, 29.5 mmol, 83.1percent Yield).For purification, the resulting isolated compound was charged (6.85 g, 6.85 g, 29.5mmol, 100 mass percent) into a vessel, followed by addition of Tetrahydrofuran (6 L/kg, 41.1mL, 36.4 g, 505 mmol, 100 mass percent). This mixture was heated to 66°C to form ahomogeneous solution. Heptane (4 L/kg, 27.4 mL, 18.7 g, 187 mmol, 100 mass percent, wasadded slowly at 66°C; solids began to precipitate after 5 volumes. The mixture wascooled to 25°C over 3 hours, then filtered and washed with heptane, followed by dryingin the high vacuum oven overnight. Isolated compound (4.93 g, 4.93 g, 21.2 mmol, 100mass percent, 72.0percent Yield). This isolated compound is Form 2 shown in FIG. 2. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
With sodium cyanoborohydride; at 20℃; for 20h; | Dissolve 5-fluoroindole (1.0 g) in CH3COOH (10 0 mL) under nitrogen atmosphere. Add anhydrous powdered NaCNBH3 (1.44 g) to this mixture and stir at room temperature for 20 hours. Concentrate the reaction mixture under vacuum, dilute with water (50 mL), adjust the pH of the reaction mixture to 9.0, extract with CH2Cl2 (2 x 75 mL) and dry over MgSO4. Filter and concentrate under vacuum to afford crude product. Puϖfy the crude by flash column chromatography using 25% EtOAc / hexane to afford the title product. | |
With sodium cyanoborohydride; acetic acid; at 20℃; for 1h; | 5-Fluoroindole (3 g, 22.2 mmol) in glacial acetic acid (35 mL) was treated with sodium cyanoborohydride (2.79 mg, 44.4 mmol) portionwise at room temperature with stirring. After one hour, the reaction was diluted with water and basified with 40% sodium hydroxide with cooling. The mixture was extracted 3 times with dichloromethane, dried and concentrated to give 5-fluoroindoline. It was used in the next step without further purification. 1H-NMR (300 MHz, dimethylsulfoxide-d6) δ 6.86 (m, 1H), 6.68 (dt, 1H), 6.42 (dd, 1H), 5.32 (br s, 1H, NH), 3.38 (m, 2H, CH2), 2.87 (t, 2H, CH2). | |
With sodium cyanoborohydride; In acetic acid; at 20℃; for 1h; | [0280] 5-Fluoroindole (3 g, 22.2 mmol) in glacial acetic acid (35 mL) was treated with sodium cyanoborohydride (2.79 mg, 44.4 mmol) portionwise at room temperature with stirring. After one hour, the reaction was diluted with water and basified with 40% sodium hydroxide with cooling. The mixture was extracted 3 times with dichloromethane, dried and concentrated to give 5-fluoroindoline. It was used in the next step without further purification. 1H-NMR (300 MHz, dimethylsulfoxide-d6) δ 6.86 (m, 1H), 6.68 (dt, 1H), 6.42 (dd, 1H), 5.32 (br s, 1H, NH), 3.38 (m, 2H, CH2), 2.87 (t, 2H, CH2). |
With sodium tetrahydroborate; acetic acid; at 10 - 20℃; for 2h; | 5-Fluoro-1H-indole 16a (1000 mg, 7.4 mmol, Shanghai Bied Chemical Reagent Co., Ltd.) was dissolved in acetic acid(12 mL), cooled to 10 to 15 C, sodium borohydride (930 mg, 14.8 mmol) was added in portions, and the mixture was slowly warmed to room temperature for 2 hours.The reaction solution was distilled under reduced pressure to remove an organic solvent. The crude title compound 16b (2000 mg) was obtained. | |
With sodium cyanoborohydride; acetic acid; at 20℃; | General procedure: To a solution ofcompound 7 (1 mmol) in glacial acetic acid (10 mL) at room temperature, sodium cyanoborohydride (0.19 g, 3 mmol) was added.Then, the reaction was stirred at room temperature, monitored byTLC. Basification of the solution by NaHCO3 (satd) was accomplished until pH value was about 8. The solutionwas extracted with CH2Cl2. The combined organic layers were dried by MgSO4 and concentrated in vacuo to afford compound 8 for the next step without further purification. | |
With hydrogen; In isopropyl alcohol; at 100℃; for 12h;Autoclave; | General procedure: Hydrogenation was carried out in a stainless-steel autoclave equipped with a pressurecontrol system. Typically, 1 mmol of quinolines and 10 mg of various catalysts weremixed in 2 mL of isopropanol. The reactions were performed in an autoclave purgedwith 1 MPa of H2 at 80 oC. The products were analyzed by gas chromatography-massspectrometer (GC-MS) and GC with m-xylene as the internal standard. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
75% | Reference Example 27; 5-Fluoro-4-(4,4,5,5-tetramethyl-[l,3,2]dioxaborolan-2-yI)-lJ?-indole; A solution of 5-fluoroindole (5 g, 37.0 mmol) in DMF (40 mL) was treated at 0 0C with trifluoroacetic anhydride (6.1 mL, 42.6 mmol). After 30 min, the reaction was poured into water and the resulting precipitate collected by filtration, washed with water, then dried in vacuo. The solid was then dissolved in 10% aqueous NaOH (200 mL) and heated at reflux for 1 h. The reaction mixtur was then cooled, washed with dichloromethane and acidified with aqueous HCl. The resulting white precipitate was collected by filtration, washed with water, taken up in dichloromethane, washed with water, dried (MgSO4) and evaporated in vacuo. The resulting material (5 g, 75%) was dissolved in methanol (80 mL) and treated with concentrated sulphuric acid (2 mL) <n="75"/>then heated at reflux overnight. The reaction was cooled and the resulting precipitate collected, washed with water and evaporated in vacuo to give 5-fluoro-lH-indole-3- carboxylic acid methyl ester as a peach-coloured solid (4.5 g, 83 %). | |
68% | In N,N-dimethyl-formamide; at 0 - 20℃;Inert atmosphere; | [00194] This compound was prepared according to the procedure described in the Journal of Medicinal Chemistry 2014, 57(17), 7293 - 7316. Trifluoroacetic anhydride (38 mL, 56.0 g, 0.27 mol) was added dropwise to a solution of 5-fluoro-lH-indole (30.0 g, 0.22 mol) in DMF (300 mL) over 0.5 h at 0C. The reaction mixture was allowed to warm to room temperature and stirred overnight. The mixture was quenched with water (1 L), after which solids began to form, the mixture was stirred for 0.5 h, then filtered. The solid was collected, washed with water (200 mL><3), then added to aqueous sodium hydroxide (20%, 150 mL, 0.75 mol) and heated under reflux for 8 h. The reaction mixture was cooled and acidified with aqueous 3N HC1 to pH of 3 whereupon a precipitate was produced. The solid was collected by filtration, washed with water (200 mLx3), dried to afford compound 2 (27.1 g, 68% yield) as off-white solid |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
5-fluoro-indole (15.0 g, 135.2 mmol) was dissolved in dry Et2O (450 ml) and cooled to 0 C. before a solution of oxalyl chloride in dry Et2O (50 ml) was added over 15 min. The mixture was stirred 30 min at 0 C. and 3 hours at room temperature. The crystals were collected by filtration and washed with Et2O to give 19.5 g of solid which was dissolved in EtOH (140 ml) and cooled to 0 C. before triethylamine (9.6 g) was added drop-wise. The mixture was refluxed for 3 hours and stirred at room temperature for 24 hours. The crystals were collected by filtration and washed with H2O and Et2O to give 18.0 g of solid which, after drying in a vacuum oven, was dissolved in dry THF (150 ml) and added drop-wise to a cooled suspension (5-15 C.) of LiAlH4 (16.1 g) in dry THF (350 ml). The mixture was refluxed for 4 hours and cooled to 10 C. After drop-wise addition of H2O (16 ml), aqueous (15%) NaOH (16 ml) and H2O (80 ml), the solution was filtered and evaporated to almost dryness. The remanence was dissolved in EtOAc and dried with MgSO4. Evaporation of the solvent gave the 2-(5-fluoroindol-3-yl)ethanol (15.2 g) as an oil, which was treated as described in Example 19, starting with the borane trimethylamine reduction followed by acylation, to give the mesylate of the title compound which was refluxed for 2 hours in acetone (200 ml) with LiBr (8.0 g). The mixture was cooled, filtered, evaporated and purified by column chromatography using EtOAc:heptane=1:2 as the eluent to give the title compound (9.0 g). |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
94% | With lithium tert-butoxide; In N,N-dimethyl-formamide; at 100℃; under 760.051 Torr; for 24h; | General procedure: In a dried two-necked test tube was charged with LiOtBu (160 mg, 2.00 mmol) and indole 1a (23.4 mg, 0.4 mmol). The reaction vessel was evacuated under high vacuum and the atmosphere was replace with a balloon of CO2. Then DMF (2 mL) was added and the mixture was stirred for 24 h at 100C. Then the result mixture was cooled and carefully quenched with a solution of HCl (2 N) and extracted with EtOAc (5x). The combined organic layers were washed with water (2x), brine (1x) and dry over MgSO4. The dried organics were concentrated under reduce pressure and the residue was purified by preparative TLC (hexane:acetone = 1:1) to afford the desired product 2a (153.0 mg, 95%) as a white solid. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
68% | General procedure: A heterogeneous mixture of <strong>[521-73-3]isoquinoline-1,3,4-trione</strong>(17.5 mg, 0.1 mmol), indole (14.0 mg, 0.12 mmol) and alginic acid (1.76 mg,0.01 mmol, purchased from Sigma Aldrich) in H2O (0.2 mL) was stirred for 24 h(monitored by TLC). Afterwards, the reaction mixture was concentrated under reduced pressure to leave the crude residue which was purified by column chromatography over silica-gel using ethyl acetate/hexane as a mixture of solvent to give the pure compound 3aa in75% yield (21.9 mg) as a white solid.4-Hydroxy-4-(1H-indol-3-yl)isoquinoline-1,3(2H,4H)-dione (3aa): yield 75%; mp:188-190 C; Rf = 0.25 (EtOAc/hexane = 1:3); 1H NMR (400 MHz, acetone-d6) d10.24 (br s, 1H, NH), 10.10 (br s, 1H, NH), 8.14 (d, J = 7.8 Hz, 1H), 7.89 (d,J = 7.8 Hz, 1H), 7.76-7.79 (m, 2H), 7.59-7.63 (m, 1H), 7.36 (d, J = 8.2 Hz, 1H),7.06-7.10 (m, 1H), 6.96-7.00 (m, 1H), 6.65-6.66 (m, 1H), 5.66 (br s, 1H, OH); 13CNMR (100 MHz, acetone-d6) d 175.0 (CO), 164.7 (CO), 144.3, 138.0, 134.7,129.2, 128.2, 127.9, 125.8, 125.8, 124.8, 122.6, 122.4, 121.7, 120.1, 112.4, 74.7(C-4, quaternary); HRMS (ESI) m/z calcd For C17H12N2O3 [M+Na]+: 315.0897.Found 315.0953. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
90% | Under N2 atmosphere, 5-fluoro-lH-indole (1.14 g, 8.45 mmol, 15 1.20 equiv) was dissolved in DMF (35.2 mL, 0.240 M) and stirred at 0 °C. NaH (0.338g, 8.45 mmol, 1.20 equiv, 60 percent dispersion in mineral oil) was added in portionwise. After 30 min, <strong>[456-24-6]2-fluoro-5-nitropyridine</strong> (1.00 g, 7.04 mmol. 1.00 equiv) was added and then the reaction mixture was slowly warmed up to 60 °C and stirred at 60 °C for 16 h. 20 The reaction mixture was poured to a solution of LiCl (100 mL) , extracted with EtOAc, and washed with brine. The combined organic layers was dried (MgSCi) , filtered and concentrated in vacuo. The residue was purified by chromatography on silica gel, eluting with hexanes : EtOAc (10:1 to 5:1 (v/v)), to afford the title compound as a 25 yellow solid (1.63 g, 6.34 mmol, 90percent yield). R/ = 0.20 (hexanes : EtOAc 5:1 (v/v)). JH NMR (700 MHz, CDC13, 25 °C, delta) : 9.39 (d, J =2.15 Hz, 1H), 8.58 (dd, J = 9.03, 2.58 Hz, 1H) , 8.51 (dd, J = 9.25, 4.52 Hz, 1H), 7.76 (d, J = 3.87 Hz, 1H) , 7.54 (d, J = 9.04 Hz, 1H) , 7.30 (dd, J = 9.03, 2.58 Hz, 1H) , 7.11 (td, J = 9.03, 2.58 Hz, 1H) , 6.78 (d, J 30 = 3.01 Hz, 1H) . 13C NMR (175 MHz, CDC13, 25 °C, delta) : 159.5 (d, J= 238.8 Hz), 155.8, 145.6 (d, J= 3.50 Hz), 140.4, 134.0, 132.1(J = 9.94 Hz), 126.5, 116.4 (d, J = 9.00 Hz), 112.5 (d, J = 24.7 Hz), 112.0, 108.9 (d, J = 3.76 Hz), 106.8 (d, J= 23.6 Hz). 19F NMR (376 MHz, CDCI3, 25 °C, delta) : -121.5.0 (m) . Mass Spectrometry: HRMS (ESI-TOF) (m/z) : calcd for C13H9FN3O2 ([M + H]+), 258.0673, found, 258.0675. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86% | With trimethylamine-N-oxide; In toluene; at 100℃; for 20h;Inert atmosphere; Schlenk technique; | General procedure: In a 2-neck RBF, 1 (20 mg, 0.0005 mmol) and TMNO (45 mg, 0.6 mmol) were suspended in toluene (4 mL) and to this solution indoline (60 mg, 0.5 mmol) was added. The reaction mixture was then heated to 100 oC for 20 h and it was filtered and solvent evaporated. The crude product obtained was purified by column chromatography using hexane/ethylacetate (7:1) as eluent to give pure indole (47 mg, 79%). A similar procedure was used for the other indolines and N-heterocycles. |
Tags: 5-Fluoroindole | Indoles | Fluorinated Building Blocks | Organic Building Blocks | Heterocyclic Building Blocks | 399-52-0
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P302 + P334 | IF ON SKIN: Immerse in cool water/wrap in wet bandages. |
P302 + P350 | IF ON SKIN: Gently wash with plenty of soap and water. |
P303 + P361 + P353 | IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower. |
P304 + P312 | IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell. |
P304 + P340 | IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing. |
P304 + P341 | IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing. |
P305 + P351 + P338 | IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing. |
P306 + P360 | IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes. |
P307 + P311 | IF exposed: call a POISON CENTER or doctor/physician. |
P308 + P313 | IF exposed or concerned: Get medical advice/attention. |
P309 + P311 | IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician. |
P332 + P313 | IF SKIN irritation occurs: Get medical advice/attention. |
P333 + P313 | IF SKIN irritation or rash occurs: Get medical advice/attention. |
P335 + P334 | Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages. |
P337 + P313 | IF eye irritation persists: Get medical advice/attention. |
P342 + P311 | IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician. |
P370 + P376 | In case of fire: Stop leak if safe to Do so. |
P370 + P378 | In case of fire: |
P370 + P380 | In case of fire: Evacuate area. |
P370 + P380 + P375 | In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion. |
P371 + P380 + P375 | In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion. |
Storage | |
Code | Phrase |
P401 | |
P402 | Store in a dry place. |
P403 | Store in a well-ventilated place. |
P404 | Store in a closed container. |
P405 | Store locked up. |
P406 | Store in corrosive resistant/ container with a resistant inner liner. |
P407 | Maintain air gap between stacks/pallets. |
P410 | Protect from sunlight. |
P411 | |
P412 | Do not expose to temperatures exceeding 50 oC/ 122 oF. |
P413 | |
P420 | Store away from other materials. |
P422 | |
P402 + P404 | Store in a dry place. Store in a closed container. |
P403 + P233 | Store in a well-ventilated place. Keep container tightly closed. |
P403 + P235 | Store in a well-ventilated place. Keep cool. |
P410 + P403 | Protect from sunlight. Store in a well-ventilated place. |
P410 + P412 | Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF. |
P411 + P235 | Keep cool. |
Disposal | |
Code | Phrase |
P501 | Dispose of contents/container to ... |
P502 | Refer to manufacturer/supplier for information on recovery/recycling |
Physical hazards | |
Code | Phrase |
H200 | Unstable explosive |
H201 | Explosive; mass explosion hazard |
H202 | Explosive; severe projection hazard |
H203 | Explosive; fire, blast or projection hazard |
H204 | Fire or projection hazard |
H205 | May mass explode in fire |
H220 | Extremely flammable gas |
H221 | Flammable gas |
H222 | Extremely flammable aerosol |
H223 | Flammable aerosol |
H224 | Extremely flammable liquid and vapour |
H225 | Highly flammable liquid and vapour |
H226 | Flammable liquid and vapour |
H227 | Combustible liquid |
H228 | Flammable solid |
H229 | Pressurized container: may burst if heated |
H230 | May react explosively even in the absence of air |
H231 | May react explosively even in the absence of air at elevated pressure and/or temperature |
H240 | Heating may cause an explosion |
H241 | Heating may cause a fire or explosion |
H242 | Heating may cause a fire |
H250 | Catches fire spontaneously if exposed to air |
H251 | Self-heating; may catch fire |
H252 | Self-heating in large quantities; may catch fire |
H260 | In contact with water releases flammable gases which may ignite spontaneously |
H261 | In contact with water releases flammable gas |
H270 | May cause or intensify fire; oxidizer |
H271 | May cause fire or explosion; strong oxidizer |
H272 | May intensify fire; oxidizer |
H280 | Contains gas under pressure; may explode if heated |
H281 | Contains refrigerated gas; may cause cryogenic burns or injury |
H290 | May be corrosive to metals |
Health hazards | |
Code | Phrase |
H300 | Fatal if swallowed |
H301 | Toxic if swallowed |
H302 | Harmful if swallowed |
H303 | May be harmful if swallowed |
H304 | May be fatal if swallowed and enters airways |
H305 | May be harmful if swallowed and enters airways |
H310 | Fatal in contact with skin |
H311 | Toxic in contact with skin |
H312 | Harmful in contact with skin |
H313 | May be harmful in contact with skin |
H314 | Causes severe skin burns and eye damage |
H315 | Causes skin irritation |
H316 | Causes mild skin irritation |
H317 | May cause an allergic skin reaction |
H318 | Causes serious eye damage |
H319 | Causes serious eye irritation |
H320 | Causes eye irritation |
H330 | Fatal if inhaled |
H331 | Toxic if inhaled |
H332 | Harmful if inhaled |
H333 | May be harmful if inhaled |
H334 | May cause allergy or asthma symptoms or breathing difficulties if inhaled |
H335 | May cause respiratory irritation |
H336 | May cause drowsiness or dizziness |
H340 | May cause genetic defects |
H341 | Suspected of causing genetic defects |
H350 | May cause cancer |
H351 | Suspected of causing cancer |
H360 | May damage fertility or the unborn child |
H361 | Suspected of damaging fertility or the unborn child |
H361d | Suspected of damaging the unborn child |
H362 | May cause harm to breast-fed children |
H370 | Causes damage to organs |
H371 | May cause damage to organs |
H372 | Causes damage to organs through prolonged or repeated exposure |
H373 | May cause damage to organs through prolonged or repeated exposure |
Environmental hazards | |
Code | Phrase |
H400 | Very toxic to aquatic life |
H401 | Toxic to aquatic life |
H402 | Harmful to aquatic life |
H410 | Very toxic to aquatic life with long-lasting effects |
H411 | Toxic to aquatic life with long-lasting effects |
H412 | Harmful to aquatic life with long-lasting effects |
H413 | May cause long-lasting harmful effects to aquatic life |
H420 | Harms public health and the environment by destroying ozone in the upper atmosphere |
Sorry,this product has been discontinued.
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