3456-75-5|2-(5-Fluoro-2-nitrophenyl)acetonitrile| Ambeed

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type	HazMat fee for 500 gram (Estimated)
Excepted Quantity	USD 0.00
Limited Quantity	USD 15-60
Inaccessible (Haz class 6.1), Domestic	USD 80+
Inaccessible (Haz class 6.1), International	USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic	USD 100+
Accessible (Haz class 3, 4, 5 or 8), International	USD 200+

Structure of 3456-75-5

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}

Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 3456-75-5 ] Purity: 95% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 3456-75-5 ]

CAS No. :	3456-75-5
Formula :	C₈H₅FN₂O₂
M.W :	180.14
SMILES Code :	N#CCC1=CC(F)=CC=C1[N+]([O-])=O
MDL No. :	MFCD00039742
InChI Key :	YETOJTGGLXHUCS-UHFFFAOYSA-N
Pubchem ID :	18945

Safety of [ 3456-75-5 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H302-H312-H315-H319-H331-H335
Precautionary Statements:	P261-P280-P305+P351+P338-P304+P340-P405-P501
Class:	6.1
UN#:	2811
Packing Group:	Ⅲ

Application In Synthesis of [ 3456-75-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 3456-75-5 ]

[ 3456-75-5 ] Synthesis Path-Downstream 1~35

1
[ 3456-75-5 ]
[ 94714-58-6 ]
6-Ethoxy-5-(5-fluoro-2-nitro-phenyl)-2-(2,3,4,5-tetrafluoro-phenyl)-nicotinic acid ethyl ester [ No CAS ]

References: [1]Tetrahedron Letters,1993,vol. 34,p. 3259 - 3262.

2
[ 3456-75-5 ]
[ 75-07-0 ]
[ 152562-00-0 ]

References: [1]Tetrahedron,1993,vol. 49,p. 5315 - 5326.

3
[ 107-14-2 ]
[ 350-46-9 ]
[ 3456-75-5 ]

Yield	Reaction Conditions	Operation in experiment
32%	With potassium tert-butylate; In tetrahydrofuran; at -20 - -10℃; for 0.333333h;	To a cooled solution of potassium tert-butoxide (3.2 g, 28.4 mmol) in THF (20 ml), a solution of 2-chloroacetonitrile (compound 14b, 1.0 g, 14.2 mmol) and 1-fluoro-4-nitrobenzene (compound 17a, 2.0 g, 14.2 mmol) in THF (20 ml) was added within 10 mins. During the addition the reaction temperature was kept at -10 0C to -200C. About 10 mins after the addition was completed, the mixture was acidified with HCl (1 N) to pH around 5, and extracted with DCM (100 mL) twice. The combined organic layer was washed with water and brine, dried over Na2SO4, filtered, and concentrated in vacuo. The residue was purified by silica gel column chromatography (eluted with PE:EtOAc = 20 : 1 to 4 : 1) to afford compound 17b (820 mg, 32% yield) 79 [(M-H)-], measured 179 [(M-H)-].

References: [1]Bulletin of the Polish Academy of Sciences: Chemistry,1985,vol. 33,p. 427 - 432.
[2]Patent: WO2020/48595,2020,A1 .Location in patent: Page/Page column 30-32.

4
[ 3456-75-5 ]
[ 350-46-9 ]
(2,2'-dinitro-5-fluorodiphenyl)acetonitrile [ No CAS ]

References: [1]Polish Journal of Chemistry,1992,vol. 66,p. 1125 - 1129.

5
[ 3456-75-5 ]
[ 1493-27-2 ]
(2,2;-dinitro-5-fluorodiphenyl)acetonitrile [ No CAS ]

References: [1]Polish Journal of Chemistry,1992,vol. 66,p. 1125 - 1129.

6
[ 501-00-8 ]
[ 3456-75-5 ]

References: [1]Journal of Heterocyclic Chemistry,1965,vol. 2,p. 298 - 299.

7
[ 3456-75-5 ]
[ 104-88-1 ]
(Z)-3-(4-Chloro-phenyl)-2-(5-fluoro-2-nitro-phenyl)-acrylonitrile [ No CAS ]

References: [1]Tetrahedron,1997,vol. 53,p. 5501 - 5514.

8
[ 3456-75-5 ]
5-Fluoro-benzo[c]isoxazole-3-carbonitrile [ No CAS ]

References: [1]Synthesis,1997,p. 753 - 755.

9
[ 110-91-8 ]
[ 3456-75-5 ]
[ 210364-40-2 ]