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Chemical Structure| 46118-02-9 Chemical Structure| 46118-02-9
Chemical Structure| 46118-02-9

4-(3-Hydroxypropyl)benzene-1,2-diol

CAS No.: 46118-02-9

4.5 *For Research Use Only !

Cat. No.: A383068 Purity: 95%

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Product Details of [ 46118-02-9 ]

CAS No. :46118-02-9
Formula : C9H12O3
M.W : 168.19
SMILES Code : OC1=CC=C(CCCO)C=C1O
MDL No. :MFCD09028769

Safety of [ 46118-02-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 46118-02-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 46118-02-9 ]

[ 46118-02-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 46118-02-9 ]
  • [ 628-97-7 ]
  • 3-(3,4-dihydroxyphenyl)propyl palmitate [ No CAS ]
  • 2
  • [ 2305-13-7 ]
  • [ 46118-02-9 ]
YieldReaction ConditionsOperation in experiment
98% With zeolite beta (Zeolyst, CP814C); In water; at 250℃; under 37503.8 Torr; for 6h;Sealed tube; Inert atmosphere; This experiment was performed according to a modified General procedure A. Dihydroconiferylalcohol (182 mg, 1 mmol) was used as the substrate, zeolite beta (Zeolyst, CP814C, Si02/Al203 = 38, H form) (100 mg) as acidic catalyst and H20 (2 mL) as the solvent. The reaction was performed at 250 °C for 6 h under 50 bar of N2 pressure. The zeolite was removed by filtration, using n-propanol, prior to freeze drying. Dihydrocaffeylalcohol was obtained in 98percent yield. General procedure A (0233) A 4 mL glass vial was charged with a magnetic stirring bar, the substrate for the experiment, the acid or alkaline reagent and 2 mL of the appropriate solvent or solvent mixture. The vial was closed properly with the correct cap and septum and the septum was pierced with a syringe needle. This vial was brought to the 4620 Parr reactor and the reactor was closed properly. The reactor was flushed with the appropriate gas (3 x 10 bar) and then filled with this gas (with the reported pressure). The reactor was heated to the reaction temperature and this temperature was maintained for the reported reaction time (it takes approx. 60 min to reach 250 °C). After cooling down (from 250 °C to 170 °C in the air and from 170 °C to r.t. in an ice bath), the gas was released and the reactor was opened. (0234) After opening the reactor, the crude reaction mixture was brought to a roundbottomed flask and the vial was rinsed with H20 (3 mL). This aqueous reaction mixture was freezed by gently rotating the flask in liq. N2. Subsequently, vacuum was applied until all volatiles were removed. If necessary, this freeze drying step was repeated multiple times. The residue was redissolved in acetone, filtered over a silica plug and the filtrate was concentrated under reduced pressure by using a rotary evaporator. The residue was analysed with NMR and MS (APCI) or LC-MS.
 

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