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Chemical Structure| 456-88-2 Chemical Structure| 456-88-2
Chemical Structure| 456-88-2

H-DL-Phe(3-F)-OH

CAS No.: 456-88-2

H-DL-Phe(3-F)-OH is a fluorophenylalanine derivative, commonly used in organic synthesis as an intermediate in polypeptide synthesis, enhancing peptide chain stability, and widely applied in drug synthesis.

Synonyms: H-DL-Phe(3-F)-OH

4.5 *For Research Use Only !

Cat. No.: A262287 Purity: 95%

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Product Details of H-DL-Phe(3-F)-OH

CAS No. :456-88-2
Formula : C9H10FNO2
M.W : 183.18
SMILES Code : NC(CC1=CC(F)=CC=C1)C(O)=O
Synonyms :
H-DL-Phe(3-F)-OH
MDL No. :MFCD00004273
InChI Key :VWHRYODZTDMVSS-UHFFFAOYSA-N
Pubchem ID :9976

Safety of H-DL-Phe(3-F)-OH

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of H-DL-Phe(3-F)-OH

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 456-88-2 ]

[ 456-88-2 ] Synthesis Path-Downstream   1~29

  • 1
  • [ 143051-43-8 ]
  • [ 456-88-2 ]
  • 3
  • [ 17607-28-2 ]
  • [ 456-88-2 ]
  • 4
  • [ 587-41-7 ]
  • [ 456-88-2 ]
  • 5
  • [ 354-32-5 ]
  • [ 456-88-2 ]
  • [ 39801-55-3 ]
  • 6
  • [ 75-44-5 ]
  • [ 456-88-2 ]
  • [ 87184-31-4 ]
  • 7
  • [ 67818-94-4 ]
  • [ 456-88-2 ]
  • [ 87184-33-6 ]
  • 8
  • [ 58632-95-4 ]
  • [ 456-88-2 ]
  • [ 87184-23-4 ]
  • 9
  • [ 80980-62-7 ]
  • [ 130835-04-0 ]
  • [ 456-88-2 ]
  • [ 80980-59-2 ]
  • 11
  • [ 456-88-2 ]
  • (RS)-3-(3'-Fluorophenyl)lactic acid [ No CAS ]
YieldReaction ConditionsOperation in experiment
7.5 mg With water; trifluoroacetic acid; In dichloromethane; at 25℃; for 0.5h; General procedure: 50 mumols of resin 1 was treated with 100 mumols of 0.20 M BTPP in NMP followed by 100 mumols of 0.20 M fluorinated benzyl bromide R1X in NMP. After two days the reaction mixture was filtered and the resulting resin 2 was washed once with 3 mL of THF. To the resin was then added 2.5 mL of 1.0 N HCl in THF (1:2). After 20 minutes the resin was filtered and was washed with 3 mL of THF followed by 2×2.5 mL of 0.20 M diisopropylethylamine in NMP, 2×2.5 mL of NMP, 3×2 mL of THF and 3×3 mL of dichloromethane to give resin 3. Treatment of resin 3 with 2 mL of 35:60:5 TFA/DCM/H2O for 30 minutes was followed by filtering and washing the resin with 2 mL of 35:60:5 TFA/DCM/H2O and 2 mL of DCM. The combined filtrates were evaporated to a residue which was chromatographed on silica gel using iPrOH/MeOH/NH4OH mobile phases to elute the free bases 4.
  • 15
  • [ 456-88-2 ]
  • [ 82911-69-1 ]
  • Fmoc-Phe(3-F)-OH [ No CAS ]
  • 17
  • [ 78-83-1 ]
  • [ 456-88-2 ]
  • 2-Amino-3-(3-fluoro-phenyl)-propionic acid isobutyl ester; hydrochloride [ No CAS ]
  • 18
  • [ 207910-83-6 ]
  • [ 456-88-2 ]
  • 19
  • 3-(3-fluorophenyl)-2-oxopropionic acid ethyl ester [ No CAS ]
  • [ 456-88-2 ]
  • 26
  • [ 456-88-2 ]
  • Tropanyl (RS)-3-(3'-fluorophenyl)lactate [ No CAS ]
  • 27
  • [ 456-88-2 ]
  • (R)-N-phenylacetyl-3-fluorophenylalanine [ No CAS ]
  • 28
  • [ 456-88-2 ]
  • [ 87184-34-7 ]
  • 29
  • [ 456-88-2 ]
  • [ 87184-24-5 ]
 

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