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[ CAS No. 454482-11-2 ]

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Chemical Structure| 454482-11-2
Chemical Structure| 454482-11-2
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Product Details of [ 454482-11-2 ]

CAS No. :454482-11-2 MDL No. :MFCD11506069
Formula : C12H22BNO2 Boiling Point : 252.5°C at 760 mmHg
Linear Structure Formula :- InChI Key :N/A
M.W :223.12 g/mol Pubchem ID :20773371
Synonyms :

Safety of [ 454482-11-2 ]

Signal Word:Warning Class:N/A
Precautionary Statements:P261-P305+P351+P338 UN#:N/A
Hazard Statements:H315-H319-H335 Packing Group:N/A
GHS Pictogram:

Application In Synthesis of [ 454482-11-2 ]

  • Upstream synthesis route of [ 454482-11-2 ]
  • Downstream synthetic route of [ 454482-11-2 ]

[ 454482-11-2 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 73183-34-3 ]
  • [ 180692-27-7 ]
  • [ 454482-11-2 ]
Reference: [1] Patent: US2006/199817, 2006, A1, . Location in patent: Page/Page column 37
[2] Patent: US2003/225106, 2003, A1, . Location in patent: Page 60; 83
  • 2
  • [ 1195-66-0 ]
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YieldReaction ConditionsOperation in experiment
63%
Stage #1: With TurboGrignard In tetrahydrofuran at -15 - -10℃; Inert atmosphere
Stage #2: at 20℃;
2nd step: under the protection of nitrogen, the 1.3M isopropyl magnesium chloride-lithium chloride (72 ml, 94mmol) into the reaction bottle, temperature control -15 ° C to -10 °C, dropwise N-methyl -1, 2, 5, 6-tetrahydro-pyridine-4-polybromide tetrahydrofuran (80 ml) solution, stirring finishing joining 1-2 hours. After the end of the exchange, then drop by adding methoxy boronic acid pinacone ester (15.8g, 0 . 1mol), subsequently maintain the reaction at room temperature overnight. Adding 10percent hydrochloric acid aqueous solution quenching reaction, adjusting PH= 4-5, by adding 150 ml ethyl acetate, saturated salt water an organic layer, the organic layer after evaporation to dryness, add ethanol/heptane 40:1 obtained after pulping 14.1g kind of white solid N-methyl -1, 2, 5, 6-tetrahydro-pyridine-4-boronic acid frequency that alcohol ester, GC: 98.3percent, yield: 63percent.
Reference: [1] Patent: CN105566367, 2016, A, . Location in patent: Paragraph 0017
  • 3
  • [ 50-00-0 ]
  • [ 454482-11-2 ]
Reference: [1] Patent: WO2018/67512, 2018, A1, . Location in patent: Paragraph 0267
  • 4
  • [ 1445-73-4 ]
  • [ 454482-11-2 ]
Reference: [1] Patent: CN105566367, 2016, A,
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