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Chemical Structure| 443956-11-4 Chemical Structure| 443956-11-4

Structure of 443956-11-4

Chemical Structure| 443956-11-4

3-Oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazine-6-carbaldehyde

CAS No.: 443956-11-4

4.5 *For Research Use Only !

Cat. No.: A371127 Purity: 95%

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Product Details of [ 443956-11-4 ]

CAS No. :443956-11-4
Formula : C8H6N2O3
M.W : 178.14
SMILES Code : O=CC1=CC=C(C(N2)=N1)OCC2=O
MDL No. :MFCD15526745
InChI Key :XOXXGNIBXYQQNS-UHFFFAOYSA-N
Pubchem ID :21873737

Safety of [ 443956-11-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 443956-11-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 443956-11-4 ]

[ 443956-11-4 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 337463-88-4 ]
  • [ 201230-82-2 ]
  • [ 20348-09-8 ]
  • [ 443956-11-4 ]
  • 2
  • [ 443956-11-4 ]
  • [ 480452-05-9 ]
  • tert-butyl 2-methyl-3-((3-oxo-3,4-dihydro-2H-pyrido[3,2-b][1,4]oxazin-6-yl)methylamino)propylcarbamate [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% A mixture of Dl (946 mg, 5.31 mmol) and 5-2 (1.00 g, 5.31 mmol) in CHC13 (53 mL) was stirred at room temperature for 1 hour. A solution of l/2ZnCl2-NaBH3CN (0.3 M MeOH solution, 17.7 mL, 5.31 mmol) was added to the reaction mixture and the mixture was stirred at room temperature for 3.25 hours. After quenching the reaction mixture by addition of water, the mixture was extracted with CH2C12. The organic extracts were dried over NaS04, filtered, and then concentrated under reduced pressure. Flash chromatography (CH2Cl2/MeOH/NH4OH = 10: 1 :0.01) of the residue on silica gel gave 5-3 (1.71 g, 92%). 1H NMR (400 MHz, DMSO-< 6) delta 0.87 (d, J = 6.7 Hz, 3H), 1.35 (s, 9H), 1.80- 1.95 (m, 1H), 2.54-2.64 (m, 1H), 2.66-2.76 (m, 1H), 2.81 -2.96 (m, 2H), 3.93 (s, 2H), 4.65 (s, 2H), 6.93 (br, 1H), 7.09 (d, J= 7.9 Hz, 1H), 7.37 (d, J = 7.9 Hz, 1H), 11.3 (s, 1H).
 

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