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Chemical Structure| 43132-86-1 Chemical Structure| 43132-86-1

Structure of 43132-86-1

Chemical Structure| 43132-86-1

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Product Details of [ 43132-86-1 ]

CAS No. :43132-86-1
Formula : C8H10OS
M.W : 154.23
SMILES Code : OC1=C(C)C=C(S)C=C1C
MDL No. :MFCD22481720

Safety of [ 43132-86-1 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314-H301
Precautionary Statements:P501-P270-P264-P280-P303+P361+P353-P301+P330+P331-P363-P301+P310+P330-P304+P340+P310-P305+P351+P338+P310-P405
Class:8(6.1)
UN#:2923
Packing Group:

Application In Synthesis of [ 43132-86-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 43132-86-1 ]

[ 43132-86-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 67-56-1 ]
  • [ 27741-65-7 ]
  • [ 43132-86-1 ]
  • [ 891188-23-1 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; trimethyl orthoformate; for 96h;Heating / reflux; Step 2: 6'-Hydroxy-5,7'-dimethylspiro[cyclobutane-1,2'-thiochromen]-4'(3'H)-one To a solution of 4-mercapto-2,6-dimethylphenol (2.5 g) in anhydrous methanol (40 mL) containing trimethyl orthoformate (3 mL), was added <strong>[27741-65-7]cyclobutylidene-acetic acid ethyl ester</strong> (7.6 g) and then 5 drops of concentrated sulfuric acid. The solution was deoxygenated by bubbling with nitrogen, and was allowed to reflux for 4 days. The mixture was concentrated, washed with saturated NaHCO3 and extracted with ethyl acetate. After concentrated in vacuo, the residue was purified by flash chromatography eluted with 10-20% ethyl acetate in hexane to give 3.1 g of methyl {1-[(4-hydroxy-3,5-dimethylphenyl)thio]cyclobutyl}acetate as a white solid. The above addition product (3.1 g) was suspended in 200 mL of 1N NaOH in MeOH and water (1:1, v/v), and the mixture was allowed to stir for 1 hour. The reaction mixture was then acidified with 1N HCl and extracted 3 times with ethyl acetate. The organic layer was washed with water and dried over anhydrous Na2SO4, and concentrated in vacuo.
 

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