41018-86-4|2,3-Dimethyl-7-nitro-1H-indole| Ambeed

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Quality Control of [ 41018-86-4 ] Purity: 98% SDS Specification

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Product Details of [ 41018-86-4 ]

CAS No. :	41018-86-4
Formula :	C₁₀H₁₀N₂O₂
M.W :	190.20
SMILES Code :	O=[N+](C1=CC=CC2=C1NC(C)=C2C)[O-]
MDL No. :	MFCD00022710
InChI Key :	ONCCVOJTXZBTDY-UHFFFAOYSA-N
Pubchem ID :	38742

Safety of [ 41018-86-4 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Application In Synthesis of [ 41018-86-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 41018-86-4 ]

[ 41018-86-4 ] Synthesis Path-Downstream 1~19

1
[ 41018-86-4 ]
[ 101832-73-9 ]

Yield	Reaction Conditions	Operation in experiment
	With hydrazine hydrate;aluminum nickel; In methanol;	The 7-amino-2,3-dimethylindole used as a starting material was prepared as follows:- Hydrazine hydrate (0.65 ml) was added dropwise to a stirred mixture of 2,3-dimethyl-7-nitroindole (0.5 g), Raney nickel (0.1 g) and methanol (5 ml) that had been warmed to 55 C. The resultant mixture was heated to reflux for 30 minutes. The catalyst was removed by filtration and the filtrate was evaporated. The residue was purified by column chromatography on silica using methylene chloride as eluent. There was thus obtained 7-amino-2,3-dimethylindole (0.3 g) as a solid; NMR Spectrum: (DMSOd6) 2.1 (s, 3H), 2.3 (s, 3H), 4.8 (br s, 2H), 6.25 (d, 1H), 6.65 (m, 2H).

References: [1]Journal of the Chemical Society,1954,p. 3916,3918.
[2]Journal of the Chemical Society,1954,p. 3916,3918.
[3],1955,vol. 40,p. 49,56.
[4]Journal of the Chemical Society,1958,p. 1,6.
[5]Chemistry of Heterocyclic Compounds,1981,vol. 17,p. 364 - 366.
[6]Chemical Communications,2007,p. 2121 - 2123.
[7]Patent: US2004/63733,2004,A1 .
[8]Chemical Communications,2008,p. 3007 - 3009.
[9]Angewandte Chemie - International Edition,2019,vol. 58,p. 13039 - 13043.
Angew. Chem.,2019,vol. 131,p. 13173 - 13177,5.

2
[ 41018-86-4 ]
[ 100060-35-3 ]

References: [1]Journal of the Chemical Society,1958,p. 1,6.

3
[ 41018-86-4 ]
5-bromo-2,3-dimethyl-7-nitro-indole [ No CAS ]

References: [1]Chemische Berichte,1932,vol. 65,p. 308,312.

4
[ 41018-86-4 ]
[ 194784-10-6 ]

References: [1]Journal of the Chemical Society,1953,p. 609,611.

5
[ 18587-87-6 ]
[ 41018-86-4 ]

References: [1]Chemische Berichte,1932,vol. 65,p. 308,312.
[2]Journal of the Chemical Society,1954,p. 165,170.

7
[ 41018-86-4 ]
pyridine-2,6-dicarboxylic acid bis-[(2,3-dimethyl-1H-indol-7-yl)-amide] [ No CAS ]

References: [1]Chemical Communications,2007,p. 2121 - 2123.

8
[ 41018-86-4 ]
N,N'-bis-(2,3-dimethyl-1H-indol-7-yl)-isophthalamide [ No CAS ]

References: [1]Chemical Communications,2007,p. 2121 - 2123.

9
[ 41018-86-4 ]
[ 78893-57-9 ]

References: [1]Chemistry of Heterocyclic Compounds,1981,vol. 17,p. 364 - 366.

10
[ 41018-86-4 ]
[ 63594-54-7 ]

References: [1]Chemistry of Heterocyclic Compounds,1981,vol. 17,p. 364 - 366.

11
[ 41018-86-4 ]
[ 99840-47-8 ]

References: [1]Journal of the Chemical Society,1958,p. 1,6.

12
[ 41018-86-4 ]
[ 100134-44-9 ]

References: [1]Journal of the Chemical Society,1958,p. 1,6.

13
[ 41018-86-4 ]
[ 100615-19-8 ]

References: [1]Journal of the Chemical Society,1958,p. 1,6.

14
[ 41018-86-4 ]
[ 109654-87-7 ]

References: [1]Journal of the Chemical Society,1958,p. 1,6.

15
[ 41018-86-4 ]
[ 119014-20-9 ]

References: [1]Journal of the Chemical Society,1958,p. 1,6.

16
[ 3034-19-3 ]
[ 41018-86-4 ]

References: [1]Chemische Berichte,1932,vol. 65,p. 308,312.

17
[ 41018-86-4 ]
[ 55899-45-1 ]
[ 101832-73-9 ]

Yield	Reaction Conditions	Operation in experiment
70%		a) 2,3-Dimethyl-7-aminoindole (Compound 35A13-A) The title compound was prepared as described for Compound 35A1-A starting from 2,3-dimethyl-7-nitroindole (N. Moskalev et al, Tetrahedron Letters 40, 5395-5398, (1999)) instead of 2-methyl-7-nitroindole. The crude was purified by flash chromatography eluding with petroleum ether-ethyl acetate 7:3 to give the title compound (70%). 1H-NMR (δ): 2.31 (s, 3H), 2.49 (s, 3H), 3,85-4.21 (br, 2H), 6.27 (dd, 11H), 6.70 (dd, 1H), 6.94 (dd, 1H), 7.48-7.73 (br 1H)

References: [1]Patent: US2003/162777,2003,A1 .

18
[ 6293-87-4 ]
[ 78-93-3 ]
[ 41018-86-4 ]

References: [1]Synthetic Communications,2009,vol. 39,p. 158 - 165.
[2]Phosphorus, Sulfur and Silicon and the Related Elements,2009,vol. 184,p. 1843 - 1853.
[3]Letters in Organic Chemistry,2009,vol. 6,p. 159 - 164.

19
[ 41018-86-4 ]
N-(2,3-dimethyl-1H-indol-7-yl)-[2,2'-bipyridine]-5-carboxamide [ No CAS ]

References: [1]Angewandte Chemie - International Edition,2019,vol. 58,p. 13039 - 13043.
Angew. Chem.,2019,vol. 131,p. 13173 - 13177,5.

Historical Records

Related Functional Groups of
[ 41018-86-4 ]

Nitroes

A146213 [21296-94-6]

2,3-Dimethyl-5-nitro-1H-indole

Similarity: 0.91

A707993 [13687-74-6]

2,3-Dimethyl-4-nitro-1H-indole

Similarity: 0.89

A707993 [13687-74-6]

2,3-Dimethyl-4-nitro-1H-indole

Similarity: 0.89

A707993 [13687-74-6]

2,3-Dimethyl-4-nitro-1H-indole

Similarity: 0.89

A159571 [1262434-36-5]

5-Methoxy-2,3-dimethyl-7-nitro-1H-indole

Similarity: 0.88

Related Parent Nucleus of
[ 41018-86-4 ]

Indoles

A146213 [21296-94-6]

2,3-Dimethyl-5-nitro-1H-indole

Similarity: 0.91

A707993 [13687-74-6]

2,3-Dimethyl-4-nitro-1H-indole

Similarity: 0.89

A707993 [13687-74-6]

2,3-Dimethyl-4-nitro-1H-indole

Similarity: 0.89

A707993 [13687-74-6]

2,3-Dimethyl-4-nitro-1H-indole

Similarity: 0.89

A707993 [13687-74-6]

2,3-Dimethyl-4-nitro-1H-indole

Similarity: 0.89

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CAS No.: 41018-86-4

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