406204-74-8|2,4-Dichloro-6-fluoro-quinoline| Ambeed

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Quality Control of [ 406204-74-8 ] Purity: 98% SDS Specification

COA

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NMR

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CNMR

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HPLC

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LC-MS

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Product Details of [ 406204-74-8 ]

CAS No. :	406204-74-8
Formula :	C₉H₄Cl₂FN
M.W :	216.04
SMILES Code :	FC1=CC=C2N=C(Cl)C=C(Cl)C2=C1
MDL No. :	MFCD09261383
InChI Key :	XLEGVSYSXNPSAU-UHFFFAOYSA-N
Pubchem ID :	27282142

Safety of [ 406204-74-8 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 406204-74-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 406204-74-8 ]

[ 406204-74-8 ] Synthesis Path-Downstream 1~24

1
[ 406204-74-8 ]
[ 124-41-4 ]
[ 860296-85-1 ]

Yield	Reaction Conditions	Operation in experiment
69%	In methanol; at 20℃; for 2h;Heating / reflux;	b) 2-Chloro-6-fluoro-4-methoxy-quinoline; To <strong>[406204-74-8]2,4-dichloro-6-fluoro-quinoline</strong> (3.3 g, 15 mmol) in MeOH (50 mL) was added NaOMe (2.5 g, 46 mmol) at rt. under an atmosphere of nitrogen. The slurry was heated at reflux for 2 h, cooled to rt. and concentrated. The residue was purified by flash chromatography [60 g Si02, 4 x 12 cm column, eluting with DCM], which afforded 2.17 g (69%) of the title compound as a white solid material. 'H NMR (300.1 MHz, CDC) 5 7.89 (dd, 1H), 7.68 (dd, 1H), 7.43 (ddd, 1H), 6.71 (s, 1H), 4.02 (s, 3H). LC-MS [M+H] + 212

References: [1]Patent: WO2005/66132,2005,A1 .Location in patent: Page/Page column 39-40.

2
[ 141-82-2 ]
[ 371-40-4 ]
[ 406204-74-8 ]

Yield	Reaction Conditions	Operation in experiment
20%		a) 2, 4-Dichloro-6-fluoro-quinoline; To a mixture of 4-fluoroaniline (8.5 g, 76.5 mmol) and malonic acid (8.0 g, 76.9 mmol) was added POC13 (160 g, 1.04 mol) and the mixture was slowly heated to 100C and then kept at this temperature for 18 h. The reaction mixture was cooled to room temperature and poured into ice-water (1.0 L). The brown slurry was filtered and the solid brown/orange material was purified by flash chromatography [350 g Si02, 6 x 24 cm column, eluting with DCM], which afforded 3.37 g (20%) of the title compound as an off-white solid.

References: [1]Research on Chemical Intermediates,2014,vol. 40,p. 1851 - 1866.
[2]Patent: WO2005/66132,2005,A1 .Location in patent: Page/Page column 39.

3
[ 406204-74-8 ]
[ 156304-06-2 ]
[ 1424371-20-9 ]

References: [1]Research on Chemical Intermediates,2014,vol. 40,p. 1851 - 1866.

4
[ 406204-74-8 ]
[ 10354-30-0 ]
[ 1424371-10-7 ]

References: [1]Research on Chemical Intermediates,2014,vol. 40,p. 1851 - 1866.

5
[ 371-40-4 ]
[ 1663-67-8 ]
[ 406204-74-8 ]