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Chemical Structure| 860296-85-1 Chemical Structure| 860296-85-1

Structure of 860296-85-1

Chemical Structure| 860296-85-1

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Product Details of [ 860296-85-1 ]

CAS No. :860296-85-1
Formula : C10H7ClFNO
M.W : 211.62
SMILES Code : COC1=CC(Cl)=NC2=CC=C(F)C=C12
MDL No. :MFCD10000787

Safety of [ 860296-85-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 860296-85-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 860296-85-1 ]

[ 860296-85-1 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 406204-74-8 ]
  • [ 124-41-4 ]
  • [ 860296-85-1 ]
YieldReaction ConditionsOperation in experiment
69% In methanol; at 20℃; for 2h;Heating / reflux; b) 2-Chloro-6-fluoro-4-methoxy-quinoline; To <strong>[406204-74-8]2,4-dichloro-6-fluoro-quinoline</strong> (3.3 g, 15 mmol) in MeOH (50 mL) was added NaOMe (2.5 g, 46 mmol) at rt. under an atmosphere of nitrogen. The slurry was heated at reflux for 2 h, cooled to rt. and concentrated. The residue was purified by flash chromatography [60 g Si02, 4 x 12 cm column, eluting with DCM], which afforded 2.17 g (69%) of the title compound as a white solid material. 'H NMR (300.1 MHz, CDC) 5 7.89 (dd, 1H), 7.68 (dd, 1H), 7.43 (ddd, 1H), 6.71 (s, 1H), 4.02 (s, 3H). LC-MS [M+H] + 212
 

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