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Chemical Structure| 40372-61-0 Chemical Structure| 40372-61-0

Structure of 40372-61-0

Chemical Structure| 40372-61-0

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Product Details of [ 40372-61-0 ]

CAS No. :40372-61-0
Formula : C6H5BrClNO
M.W : 222.47
SMILES Code : OC1=CC(Br)=C(Cl)C=C1N

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* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 40372-61-0 ]

[ 40372-61-0 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 40372-61-0 ]
  • [ 530-62-1 ]
  • [ 5579-85-1 ]
YieldReaction ConditionsOperation in experiment
82% at 80℃; for 3 h; Intermediate 8: 6-Bromo-5-chlo H)-one A mixture of 2-amino-5-bromo-4-chlorophenol (Intermediate 7, 8.4 g, 37.8 mmol), N,N-carbonyldiimidazole (12.2 g, 75.6 mmol) in THF (250 mL), was heated at 80 °C for 3 h. The solvent was removed under vacuum and the residue purified by column chromatography (silica: 200 - 400 mesh, 100 g) eluting with petroleum ether/ ethyl acetate from 9:1 to 5:1 ) to give 6-bromo-5-chlorobenzo[d]oxazol-2(3H)-one as an orange solid (7.7 g, 82percent). LCMS (A): Rt 1.49 min, MH+ 248/250.
References: [1] Patent: WO2015/91647, 2015, A1, . Location in patent: Page/Page column 42.
 

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