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Chemical Structure| 5579-85-1 Chemical Structure| 5579-85-1
Chemical Structure| 5579-85-1

6-Bromo-5-chlorobenzo[d]oxazol-2(3H)-one

CAS No.: 5579-85-1

4.5 *For Research Use Only !

Cat. No.: A107429 Purity: 95%

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Product Details of [ 5579-85-1 ]

CAS No. :5579-85-1
Formula : C7H3BrClNO2
M.W : 248.46
SMILES Code : O=C1OC2=CC(Br)=C(Cl)C=C2N1
MDL No. :MFCD00047213
InChI Key :KVAWWXSLBDVXHJ-UHFFFAOYSA-N
Pubchem ID :21749

Safety of [ 5579-85-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302
Precautionary Statements:P280-P305+P351+P338

Application In Synthesis of [ 5579-85-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 5579-85-1 ]

[ 5579-85-1 ] Synthesis Path-Upstream   1~8

  • 1
  • [ 40372-61-0 ]
  • [ 530-62-1 ]
  • [ 5579-85-1 ]
YieldReaction ConditionsOperation in experiment
82% at 80℃; for 3 h; Intermediate 8: 6-Bromo-5-chlo H)-one A mixture of 2-amino-5-bromo-4-chlorophenol (Intermediate 7, 8.4 g, 37.8 mmol), N,N-carbonyldiimidazole (12.2 g, 75.6 mmol) in THF (250 mL), was heated at 80 °C for 3 h. The solvent was removed under vacuum and the residue purified by column chromatography (silica: 200 - 400 mesh, 100 g) eluting with petroleum ether/ ethyl acetate from 9:1 to 5:1 ) to give 6-bromo-5-chlorobenzo[d]oxazol-2(3H)-one as an orange solid (7.7 g, 82percent). LCMS (A): Rt 1.49 min, MH+ 248/250.
References: [1] Patent: WO2015/91647, 2015, A1, . Location in patent: Page/Page column 42.
  • 2
  • [ 95-25-0 ]
  • [ 5579-85-1 ]
References: [1] Journal of Pharmaceutical Sciences, 1964, vol. 53, p. 538 - 544.
  • 3
  • [ 61-80-3 ]
  • [ 5579-85-1 ]
References: [1] Journal of Pharmaceutical Sciences, 1964, vol. 53, p. 538 - 544.
  • 4
  • [ 89-21-4 ]
  • [ 5579-85-1 ]
References: [1] Patent: WO2015/91647, 2015, A1, .
  • 5
  • [ 95-03-4 ]
  • [ 5579-85-1 ]
References: [1] Patent: WO2015/91647, 2015, A1, .
  • 6
  • [ 89-61-2 ]
  • [ 5579-85-1 ]
References: [1] Patent: WO2015/91647, 2015, A1, .
  • 7
  • [ 102170-53-6 ]
  • [ 5579-85-1 ]
References: [1] Patent: WO2015/91647, 2015, A1, .
  • 8
  • [ 64037-08-7 ]
  • [ 5579-85-1 ]
References: [1] Journal of Pharmaceutical Sciences, 1964, vol. 53, p. 538 - 544.
 

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