372118-01-9|Methyl 4,6-dichloropyridazine-3-carboxylate| Ambeed

CAS No. :	372118-01-9
Formula :	C₆H₄Cl₂N₂O₂
M.W :	207.01
SMILES Code :	ClC1=C(N=NC(=C1)Cl)C(=O)OC
MDL No. :	MFCD09953612
InChI Key :	MZEVRGMQXLNKEZ-UHFFFAOYSA-N
Pubchem ID :	17848322

Safety of [ 372118-01-9 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Calculated chemistry of [ 372118-01-9 ] Show Less

Physicochemical Properties

Num. heavy atoms	12
Num. arom. heavy atoms	6
Fraction Csp3	0.17
Num. rotatable bonds	2
Num. H-bond acceptors	4.0
Num. H-bond donors	0.0
Molar Refractivity	43.33
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	52.08 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	1.94
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	1.62
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	1.57
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	1.16
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	2.05
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	1.67

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-2.38
Solubility	0.859 mg/ml ; 0.00415 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-2.33
Solubility	0.977 mg/ml ; 0.00472 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-2.97
Solubility	0.223 mg/ml ; 0.00108 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	Yes
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	Yes
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-6.41 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	0.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	0.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<1.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	1.99

Application In Synthesis of [ 372118-01-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 372118-01-9 ]

[ 372118-01-9 ] Synthesis Path-Downstream 1~6

1
[ 372118-00-8 ]
[ 372118-01-9 ]

Yield	Reaction Conditions	Operation in experiment
72%	With trichlorophosphate; at 95.0℃; for 5h;	Step 3 4,6-Dichloro-pyridazine-3-carboxylic acid methyl ester A mixture of <strong>[372118-00-8]4,6-dihydroxy-pyridazine-3-carboxylic acid methyl ester</strong> (10.5 g, 61.7 mmol) and POCl3 (70 mL) was heated to 95 C. for 5 h. The excess POCl3 was removed under reduced pressure, then the crude residue was added to ice-water (250 mL) and extracted with ethyl acetate (3*100 mL). The combined extracts were dried then concentrated to give a crude residue which was purified by chromatography (silica, 100-200 mesh, 30% ethyl acetate in hexane) to give 4,6-dichloro-pyridazine-3-carboxylic acid methyl ester (9.2 g, 72%) as an off white solid. LC-MS: 207.0 [M+H]+.
64.3%	With trichlorophosphate; for 3h;Reflux;	A slurry of <strong>[372118-00-8]methyl 4,6-dihydroxypyridazine-3-carboxylate</strong> (11.7 g, 68.8 mmol) in POCl3 (110 mL, 1180 mmol) was heated to reflux for 3h during which time the mixture became a nearly homogeneous dark brown solution. The reaction mixture was cooled to rt, allowed to stand overnight and concentrated in vacuo. The resulting dark brown residue was dissolved in DCM (?300 mL) and was slowly poured onto ?500 mL of crushed ice with swirling of the flask. After the addition was complete, water was slowly added (?200 mL) until the mixture became stirrable and the mixture was stirred while warming to rt over ?3 h. The resulting phases were separated and the aqueous portion was extracted with additional DCM (3*100 mL). The combined extracts were washed with brine, dried over anhydrous sodium sulfate, decanted and concentrated under vacuum to afford a white solid as the pure product, methyl 4,6-dichloropyridazine-3-carboxylate (9.16 g, 44.2 mmol, 64.3% yield). Material was used as is without any further purification. MS (M+1) m/z: 206.9 (MH+). LC retention time 0.80 min [A].
	With trichlorophosphate; at 95.0℃; for 4h;	Step 3.Preparation of 4,6-dichloro-pyridazine-3-carboxylic acid methyl or ethyl ester 5 A mixture of 4,6-dihydroxy-pyridazine-3-carboxylic acid methyl or ethyl ester (50 mmol) and POCl3 (90 ML) is heated at 95 C. for 4 hours.The excess POCl3 is evaporated in vacuo and to the residue cooled to 0 C. was added ice (150 g) followed by EtOAc (200 ML).The layers are separated and the aqueous layer is extracted with EtOAc (2*100 ML).The combined extracts are washed with brine (200 ML), dried (Na2SO4) and evaporated in vacuo.This residue is purified by flash column chromatography (225 g silica gel, eluted with 4:1 hexane, EtOAc).The desired 4,6 dichloro-pyridazine-3-carboxylic acid methyl ester is obtained as a white solid, while the 4,6 dichloro-pyridazine-3-carboxylic acid ethyl ester is a colorless liquid.

References: [1]Patent: US2013/178478,2013,A1 .Location in patent: Paragraph 0301;0302.
[2]Journal of Medicinal Chemistry,2014,vol. 57,p. 2683 - 2691.
[3]Patent: US2019/152948,2019,A1 .Location in patent: Paragraph 0416-0417; 0414.
[4]Patent: US2004/77653,2004,A1 .Location in patent: Page 18.

2
[ 372118-01-9 ]
[ 36936-23-9 ]
methyl 6-chloro-4-(5-chloro-6-methylpyridin-2-ylamino)pyridazine-3-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
20%	In acetonitrile; at 130℃; for 36.0h;	Step 1 Methyl 6-chloro-4-(5-chloro-6-methylpyridin-2-ylamino)pyridazine-3-carboxylate A pressure tube was charged with methyl 4,6-dichloropyridazine-3-carboxylate (2 g, 9.66 mmol) and <strong>[36936-23-9]5-chloro-6-methylpyridin-2-amine</strong> (2.76 g, 19.3 mmol). To the mixture was added acetonitrile (12 mL) and the reaction mixture heated with stirring at 130 C. for 1.5 days. After cooling to room temperature, the acetonitrile was removed in vacuo. The residue obtained was purified by chromatography (silica, 80 g, 50 mum from Analogix, 0% to 5% acetone in dichloromethane over 20 min., holding at 5% for 5 min, then increasing the gradient from 5% to 10% over the next 20 min) to give methyl 6-chloro-4-(5-chloro-6-methylpyridin-2-ylamino)pyridazine-3-carboxylate (618 mg, 20%) as an orange solid. 1H NMR (400 MHz, CHLOROFORM-d) delta ppm 10.70 (br. s., 1H), 9.18 (s, 1H), 7.63 (d, J=8.34 Hz, 1H), 6.78 (d, J=8.34 Hz, 1H), 4.12 (s, 3H), 2.66 (s, 3H), 1.58 (br. s., 1H); LC-MS 313 [M+H]+.

References: [1]Patent: US2013/178478,2013,A1 .Location in patent: Paragraph 0291;0292.

3
[ 372118-01-9 ]
[ 35196-11-3 ]
methyl 6-chloro-4-(5-(methylsulfonyl)pyridin-2-ylamino)pyridazine-3-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
19%	With tris-(dibenzylideneacetone)dipalladium(0); 4a,9a-dihydro-9,9-dimethyl-4,5-bis(diphenylphosphino)-xanthene; caesium carbonate; In 1,4-dioxane; at 100℃; for 1h;Inert atmosphere;	Step 1 Methyl 6-chloro-4-(5-(methylsulfonyl)pyridin-2-ylamino)pyridazine-3-carboxylate A flask was charged with methyl 4,6-dichloropyridazine-3-carboxylate (200 mg, 0.966 mmol), <strong>[35196-11-3]5-(methylsulfonyl)pyridin-2-amine</strong> (183 mg, 1.06 mmol), Pd2(dba)3 (88.5 mg, 0.097 mmol), xantphos (112 mg, 0.193 mmol) and cesium carbonate (944 mg, 2.9 mmol). 1,4-Dioxane (6.0 mL) was added and argon was bubbled through it while sonicating the flask for 5 min. The flask was sealed and heated at 100 C. for 1 h. After cooling the mixture was filtered through celite and the filter cake washed with CH2Cl2. The filtrates were concentrated in vacuo then purified by chromatography (spherical silica 20-45 μM, 23 g, Versaflash Supelco, 0 to 100% ethyl acetate in hexanes, 30 min) to give methyl 6-chloro-4-(5-(methylsulfonyl)pyridin-2-ylamino)pyridazine-3-carboxylate (62 mg, 19%) as a light yellow solid. 1H NMR (400 MHz, CHLOROFORM-d) δ ppm 11.18 (s, 1H) 9.31 (s, 1H) 8.98 (d, J=2.27 Hz, 1H) 8.19 (dd, J=8.59, 2.53 Hz, 1H) 7.09 (dd, J=8.84, 0.76 Hz, 1H) 4.15 (s, 3H) 3.15 (s, 3H). LCMS (EI/CI) m/z: 342.9 [M+H].

References: [1]Patent: US2013/178478,2013,A1 .Location in patent: Paragraph 0219;0220.

4
[ 372118-01-9 ]
[ 174579-31-8 ]
methyl 4-((4-(2-tert-butoxy-2-oxoethyl)phenyl)amino)-6-chloropyridazine-3-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
28%	In ethanol; at 90℃; for 5h;	Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (1 g, 5 mmol) and tert-butyl 2- (4-aminophenyl) acetate 55c (1 g, 5 mmol) were dissolved in ethanol (10 mL), Heat to 90 C and stir for 5 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate = 100/0 to 7/3),The target product 4-((4- (2-tert-butoxy-2-oxoethyl) phenyl) amino) -6-chloropyridazine-3-carboxylic acid methyl ester 55d (540 mg, colorless oil was obtained ). Yield: 28%.

References: [1]Patent: CN110818641,2020,A .Location in patent: Paragraph 0700-0702; 0711-0714.

5
[ 372118-01-9 ]
[ 52023-68-4 ]
methyl 6-chloro-4-((6-morpholinopyridin-3-yl)amino)pyridazine-3-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
89%	With N-ethyl-N,N-diisopropylamine; In ethanol; at 80℃; for 18h;	Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (1 g, 4.83 mmol),6-morpholinopyridine-3-amine (870 mg, 4.83 mmol),Diisopropylethylamine (1.24 g, 9.66 mmol) and ethanol (20 mL) were mixed, heated to 80 C and stirred for 18 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (dichloromethane / methanol = 19/1).The target product 6-chloro-4-((6-morpholinopyridin-3-yl) amino) pyridazine-3-carboxylic acid methyl ester 36a (1.5 g, yellow solid) was obtained,Yield: 89%.

References: [1]Patent: CN110818641,2020,A .Location in patent: Paragraph 0533-0539.

6
[ 372118-01-9 ]
[ 28466-26-4 ]
methyl 4-((1H-pyrazol-4-yl)amino)-6-chloropyridazine-3-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
59%	With N-ethyl-N,N-diisopropylamine; In ethanol; at 80℃; for 2h;	Compound 4,6-dichloropyridazine-3-carboxylic acid methyl ester 1a (206 mg, 1 mmol),<strong>[28466-26-4]1H-pyrazole-4-amine</strong> (83mg, 1mmol),Diisopropylethylamine (258mg, 2mmol)Mix with ethanol (20 mL), heat to 80 C and stir for 2 hours.After cooling to room temperature, the solvent was removed under reduced pressure, and the residue was purified by silica gel column chromatography (dichloromethane / methanol = 19/1).The target product 4-((1H-pyrazol-4-yl) amino) -6-chloropyridazine-3-carboxylic acid methyl ester 41a (150 mg, yellow solid) was obtained,Yield: 59%.

References: [1]Patent: CN110818641,2020,A .Location in patent: Paragraph 0567-0573.

Historical Records

Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Bouveault-Blanc Reduction • Catalytic Hydrogenation • Complex Metal Hydride Reductions • Ester Cleavage • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions with Organometallic Reagents • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling

Related Functional Groups of
[ 372118-01-9 ]

Chlorides

A163369 [65202-50-8]

Methyl 6-chloropyridazine-3-carboxylate

Similarity: 0.81

A163183 [75680-92-1]

Ethyl 6-chloro-3-pyridazinecarboxylate

Similarity: 0.78

A628767 [5096-73-1]

6-Chloropyridazine-3-carboxylic acid

Similarity: 0.75

A183312 [226410-00-0]

Methyl 3-chloro-1H-pyrrole-2-carboxylate

Similarity: 0.67

A257875 [116383-98-3]

Methyl 3-chloropicolinate

Similarity: 0.63

Esters

A163369 [65202-50-8]

Methyl 6-chloropyridazine-3-carboxylate

Similarity: 0.81

A163183 [75680-92-1]

Ethyl 6-chloro-3-pyridazinecarboxylate

Similarity: 0.78

A183312 [226410-00-0]

Methyl 3-chloro-1H-pyrrole-2-carboxylate

Similarity: 0.67

A257875 [116383-98-3]

Methyl 3-chloropicolinate

Similarity: 0.63

A175004 [1214361-05-3]

Methyl 3-chloro-6-oxo-1,6-dihydropyridine-2-carboxylate

Similarity: 0.59

Related Parent Nucleus of
[ 372118-01-9 ]

Pyridazines

A163369 [65202-50-8]

Methyl 6-chloropyridazine-3-carboxylate

Similarity: 0.81

A163183 [75680-92-1]

Ethyl 6-chloro-3-pyridazinecarboxylate

Similarity: 0.78

A628767 [5096-73-1]

6-Chloropyridazine-3-carboxylic acid

Similarity: 0.75

A339951 [2164-61-6]

Pyridazine-3-carboxylic acid

Similarity: 0.58

A881618 [120276-59-7]

3-Chloro-6-(chloromethyl)pyridazine

Similarity: 0.56

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H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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Product Details of [ 372118-01-9 ]

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Physicochemical Properties

Lipophilicity

Water Solubility

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Druglikeness

Medicinal Chemistry

Application In Synthesis of [ 372118-01-9 ]

[ 372118-01-9 ] Synthesis Path-Downstream 1~6

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Technical Information

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Related Functional Groups of
[ 372118-01-9 ]

Chlorides

Esters

Related Parent Nucleus of
[ 372118-01-9 ]

Pyridazines

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Alternative Products

Product Details of [ 372118-01-9 ]

Safety of [ 372118-01-9 ]

Calculated chemistry of [ 372118-01-9 ] Show Less

Physicochemical Properties

Lipophilicity

Water Solubility

Pharmacokinetics

Druglikeness

Medicinal Chemistry

Application In Synthesis of [ 372118-01-9 ]

[ 372118-01-9 ] Synthesis Path-Downstream 1~6

Related Products

Historical Records

Technical Information

Categories

Related Functional Groups of [ 372118-01-9 ]

Chlorides

Esters

Related Parent Nucleus of [ 372118-01-9 ]

Pyridazines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Related Functional Groups of
[ 372118-01-9 ]

Related Parent Nucleus of
[ 372118-01-9 ]