[ CAS No. 36887-98-6 ] 1,2,3,4-Tetrahydroquinolin-5-amine

Cat. No.: A573753

2D 3D

Structure of 36887-98-6 * Storage: Keep in dark place,Inert atmosphere,2-8°C

Purity	Size	Price	USA Stock *0-1 Day	Global Stock *5-7 Days	Quantity
98%	100mg	$129.00	Inquiry	Inquiry
98%	250mg	$203.00	Inquiry	Inquiry
98%	1g	$511.00	Inquiry	Inquiry

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* Storage: Keep in dark place,Inert atmosphere,2-8°C

* Shipping: Normal

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Quality Control of [ 36887-98-6 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 36887-98-6 ]

Specification

Alternatived Products of [ 36887-98-6 ]

Product Details of [ 36887-98-6 ]

CAS No. :	36887-98-6	MDL No. :	MFCD08234589
Formula :	C₉H₁₂N₂	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	WOHCILOGDCVXRE-UHFFFAOYSA-N
M.W :	148.21	Pubchem ID :	20633072
Synonyms :

Safety of [ 36887-98-6 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P280-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 36887-98-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 36887-98-6 ]

[ 36887-98-6 ] Synthesis Path-Downstream 1~21

1
[ 607-34-1 ]
[ 36887-98-6 ]

Yield	Reaction Conditions	Operation in experiment
76%	With tetrahydroxydiboron; water; at 80℃; for 8h;	General procedure: Nitro aromatic (1.0 mmol), B2(OH)4 (5.0 equiv, 5.0 mmol), and H2O (3.0 mL) were added in a10 mL tube. The reaction mixture was stirred at 80 C for 8 h. When the reaction was completemonitored by TLC, the mixture was cooled to room temperature, extracted with ethyl acetate (3 ×20 mL). The combined organic phase was dried over anhydrous Na2SO4, filtered, andconcentrated under reduced pressure. The residue was purified by silica gel columnchromatography.

Reference： [1]Organic Process Research and Development,2021,vol. 25,p. 2100 - 2109
[2]Tetrahedron Letters,1987,vol. 28,p. 77 - 80
[3]Bulletin of the Chemical Society of Japan,1989,vol. 62,p. 2968 - 2976
[4]Synlett,2018,vol. 29,p. 1765 - 1768
[5]Chemical and Pharmaceutical Bulletin,1981,vol. 29,p. 651 - 656
[6]Archiv der Pharmazie,2021,vol. 354

2
[ 611-10-9 ]
[ 36887-98-6 ]
[ 77738-79-5 ]
[ 77738-78-4 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1981,vol. 29,p. 651 - 656

3
[ 77738-77-3 ]
[ 36887-98-6 ]
[ 77738-78-4 ]

Reference： [1]Chemical and Pharmaceutical Bulletin,1981,vol. 29,p. 651 - 656

4
[ 611-34-7 ]
[ 36887-98-6 ]

Yield	Reaction Conditions	Operation in experiment
84%		General procedure: In a 1.5 mL reaction vial, B(C6F5)3 (0.025 mmol, 5.0 mol %) was dissolved in chloroform (0.60 mL), towhich diethylsilane (1.75 mmol, 3.5 equiv) was added. After shaking briefly, quinolines (1a-p, 0.50 mmol, 1.0equiv) was subsequently added to the above catalyst solution under argon atmosphere. The reaction mixturewas stirred at 25-65 oC for 6-24 h for the reaction of 1a-h, and at 25-100 oC for 2-24 h for the reaction of 1i-p,then allowed to cool down to room temperature and concentrated under reduced pressure to give the crudeproduct. This reaction mixture was then treated with 0.25 N HCl ethereal solution (7 mL) and stirred at roomtemperature for 1 h to give the solid residue, which was subsequently washed with ether. The solid residue wasthen dissolved or suspended in MeOH (1.0 mL) and neutralized with Na2CO3·H2O (0.5 g) at 0 oC. After stirringfor 2 h, MeOH was removed under reduced pressure, and the neutralized reaction residue was dissolved inCH2Cl2 and washed with brine (5 mL) and water (5 mL). The crude product was then obtained from the organicphase of CH2Cl2 solution and finally purified by column chromatography on silica gel to give 2a-h(EtOAc/Hexane = 1/9) and 2i-p (EtOAc/Hexane = 3/7).

Reference： [1]Synlett,2017,vol. 28,p. 2396 - 2400
[2]Organic and biomolecular chemistry,2020,vol. 18,p. 1214 - 1220
[3]Chinese Journal of Chemistry,2021,vol. 39,p. 2504 - 2508

5
[ 16234-14-3 ]
[ 36887-98-6 ]
C₁₅H₁₃ClN₄S [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
16.1%	With trifluoroacetic acid; In iso-butanol; at 100℃; for 15h;Inert atmosphere;	2,4-Dichlorothieno[3,2-d]pyrimidine (2 g, 9.81 mmol),2-butanol (20mL),Trifluoroacetic acid (1.12 g, 9.81 mmol),<strong>[36887-98-6]1,2,3,4-tetrahydroquinolin-5-amine</strong> (1.45 g, 9.81 mmol) was added to the reaction flask in that order.The reaction was stirred at 100 C for 15 hours under argon protection.After the reaction,Cool down to room temperature,Diluted with dichloromethane (150 mL).Then use 0.5% sodium bicarbonate solution (100mL),Wash with 5% saline (3 x 100 mL).Divided into organic layers,Dry with anhydrous sodium sulfate,filter,The filtrate was concentrated under reduced pressure.The residue is purified by preparative liquid phase (eluent: 0%-100% acetonitrile: aqueous).Obtaining 0.5 g of the title product as a light yellow solid.Yield: 16.1%.

Reference： [1]Patent: CN109206435,2019,A .Location in patent: Paragraph 0280; 0282; 0283; 0284

6
[ 36887-98-6 ]
C₂₉H₃₁N₇OS [ No CAS ]

Reference： [1]Patent: CN109206435,2019,A

7
[ 36887-98-6 ]
C₁₈H₁₅ClN₄OS [ No CAS ]

Reference： [1]Patent: CN109206435,2019,A

8
[ 496-41-3 ]
[ 36887-98-6 ]
C₁₈H₁₆N₂O₂ [ No CAS ]

Reference： [1]Archiv der Pharmazie,2021,vol. 354

9
[ 6314-28-9 ]
[ 36887-98-6 ]
C₁₈H₁₆N₂OS [ No CAS ]

Reference： [1]Archiv der Pharmazie,2021,vol. 354

10
[ 1477-50-5 ]
[ 36887-98-6 ]
C₁₈H₁₇N₃O [ No CAS ]

Reference： [1]Archiv der Pharmazie,2021,vol. 354

11
[ 36887-98-6 ]
[ 16136-58-6 ]
C₁₉H₁₉N₃O [ No CAS ]

Reference： [1]Archiv der Pharmazie,2021,vol. 354

12
[ 6480-68-8 ]
[ 36887-98-6 ]
C₁₉H₁₇N₃O [ No CAS ]

Reference： [1]Archiv der Pharmazie,2021,vol. 354

13
[ 93-10-7 ]
[ 36887-98-6 ]
C₁₉H₁₇N₃O [ No CAS ]

Reference： [1]Archiv der Pharmazie,2021,vol. 354

14
[ 933694-57-6 ]
[ 36887-98-6 ]
C₁₈H₁₈N₂O₂ [ No CAS ]

Reference： [1]Archiv der Pharmazie,2021,vol. 354

15
[ 527-72-0 ]
[ 36887-98-6 ]
C₁₄H₁₄N₂OS [ No CAS ]

Reference： [1]Archiv der Pharmazie,2021,vol. 354

16
[ 3222-50-2 ]
[ 36887-98-6 ]
C₁₆H₁₇N₃O [ No CAS ]

Reference： [1]Archiv der Pharmazie,2021,vol. 354

17
[ 455-24-3 ]
[ 36887-98-6 ]
C₁₇H₁₅F₃N₂O [ No CAS ]

Reference： [1]Archiv der Pharmazie,2021,vol. 354

18
[ 36887-98-6 ]
[ 65-85-0 ]
C₁₆H₁₆N₂O [ No CAS ]

Reference： [1]Archiv der Pharmazie,2021,vol. 354

19
[ 36887-98-6 ]
[ 99-94-5 ]
C₁₇H₁₈N₂O [ No CAS ]

Reference： [1]Archiv der Pharmazie,2021,vol. 354

20
[ 454-92-2 ]
[ 36887-98-6 ]
C₁₇H₁₅F₃N₂O [ No CAS ]

Reference： [1]Archiv der Pharmazie,2021,vol. 354

21
[ 456-22-4 ]
[ 36887-98-6 ]
C₁₆H₁₅FN₂O [ No CAS ]

Reference： [1]Archiv der Pharmazie,2021,vol. 354

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Isomers

Technical Information

• Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Hydride Reductions • Leuckart-Wallach Reaction • Mannich Reaction • Petasis Reaction • Preparation of Amines • Reactions of Amines • Specialized Acylation Reagents-Vilsmeier Reagent • Ugi Reaction

Historical Records

Related Functional Groups of
[ 36887-98-6 ]

Amines

[ 153856-89-4 ]

7-Amino-1,2,3,4-tetrahydroquinoline

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[ 451478-87-8 ]

8-Methyl-1,2,3,4-tetrahydroquinolin-7-amine

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[ 451478-86-7 ]

6-Methyl-1,2,3,4-tetrahydroquinolin-7-amine

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[ 1309976-14-4 ]

1,2,3,4-Tetrahydroquinolin-7-amine dihydrochloride

Similarity: 0.97

[ 304690-94-6 ]

1-Methyl-1,2,3,4-tetrahydroquinolin-7-amine

Similarity: 0.95

Related Parent Nucleus of
[ 36887-98-6 ]

Tetrahydroquinolines

[ 153856-89-4 ]

7-Amino-1,2,3,4-tetrahydroquinoline

Similarity: 1.00

[ 451478-87-8 ]

8-Methyl-1,2,3,4-tetrahydroquinolin-7-amine

Similarity: 1.00

[ 451478-86-7 ]

6-Methyl-1,2,3,4-tetrahydroquinolin-7-amine

Similarity: 1.00

[ 1309976-14-4 ]

1,2,3,4-Tetrahydroquinolin-7-amine dihydrochloride

Similarity: 0.97

[ 91-61-2 ]

1,2,3,4-Tetrahydro-6-methylquinoline

Similarity: 0.97

Ghs Precautionary Statements

Precautionary Statements-General
Code	Phrase
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P103	Read label before use
Prevention
Code	Phrase
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P220	Keep/Store away from clothing/combustible materials.
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P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
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P233	Keep container tightly closed.
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P285	In case of inadequate ventilation wear respiratory protection.
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P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
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P308	IF exposed or concerned:
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P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
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P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
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P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
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P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
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P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
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H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
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H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
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H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
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H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
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H351	Suspected of causing cancer
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H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

[ CAS No. 36887-98-6 ] 1,2,3,4-Tetrahydroquinolin-5-amine

Quality Control of [ 36887-98-6 ]

Related Doc. of [ 36887-98-6 ]

Product Details of [ 36887-98-6 ]

Safety of [ 36887-98-6 ]

Application In Synthesis of [ 36887-98-6 ]

[ 36887-98-6 ] Synthesis Path-Downstream 1~21

Technical Information

Related Functional Groups of [ 36887-98-6 ]

Amines

Related Parent Nucleus of [ 36887-98-6 ]

Tetrahydroquinolines

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 36887-98-6 ]

Related Parent Nucleus of
[ 36887-98-6 ]