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Chemical Structure| 355819-02-2 Chemical Structure| 355819-02-2

Structure of 355819-02-2

Chemical Structure| 355819-02-2

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Product Details of [ 355819-02-2 ]

CAS No. :355819-02-2
Formula : C13H19N3O2
M.W : 249.31
SMILES Code : CC(C)(C)OC(=O)N1CCC2=NC=C(N)C=C2C1
MDL No. :MFCD07371643
InChI Key :YHALGDJDGQKVHY-UHFFFAOYSA-N
Pubchem ID :11831817

Safety of [ 355819-02-2 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 355819-02-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 355819-02-2 ]

[ 355819-02-2 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 355819-02-2 ]
  • [ 1184950-48-8 ]
YieldReaction ConditionsOperation in experiment
With tert.-butylnitrite; copper(ll) bromide; In acetonitrile; at 0 - 20℃; for 16h; Step C: CuBr2 (402.03 mg, 1.8 mmol, 1.5 eq.) was added to a solution of t-butyl 3-amino-7,8-dihydro-5H-1,6-naphthyridine-6-carboxylate (300 mg, 1.2 mmol, 1 eq.) in acetonitrile (6 mL) at room temperature, followed bydropwise adding t-butyl nitrite (148.49 mg, 1.44 mmol, 1.2 eq.) at 0-5C to react for 1 hour. The temperature wasraised to room temperature with stirring for 15 hours. The reaction solution was poured into water (20 mL), filtered,and extracted three times with each 20 mL of ethyl acetate. The organic phase was washed twice with 30 mL ofwater each time, dried over anhydrous sodium sulfate, filtrated and concentrated to give a crude product. The crude product was purified by a silica gel chromatography column (PE/EA = 10/1 to 3/1) to give t-butyl 3-bromo-7,8-dihydro-5H-1,6-naphthyridine-6-carboxylate (180 mg, 534.5 mmol, 44.54% yield, 93% of purity) as a colorless and transparentoil.
 

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