1184950-48-8|tert-Butyl 3-bromo-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate| Ambeed

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 1184950-48-8 ] Purity: 98% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 1184950-48-8 ]

CAS No. :	1184950-48-8
Formula :	C₁₃H₁₇BrN₂O₂
M.W :	313.19
SMILES Code :	CC(C)(C)OC(=O)N1CCC2=NC=C(Br)C=C2C1
MDL No. :	MFCD14581749
InChI Key :	BWCWLVFPHPFTEW-UHFFFAOYSA-N
Pubchem ID :	66778468

Safety of [ 1184950-48-8 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 1184950-48-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1184950-48-8 ]

[ 1184950-48-8 ] Synthesis Path-Downstream 1~30

1
[ 625100-00-7 ]
[ 24424-99-5 ]
[ 1184950-48-8 ]

Yield	Reaction Conditions	Operation in experiment
97.5%	With triethylamine;dmap; In tetrahydrofuran; at 20℃; for 4h;	Step 1: t-butyl 3-bromo-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate To a flask containing 3-bromo-5,6,7,8-tetrahydro-1,6-naphthyridine (1.50 g, 7.04 mmol), was added THF (70 mL, 863 mmol), di-tert-butyldicarbonate (1.77 g, 8.10 mmol), TEA (5.89 mL, 42.2 mmol), and DMAP (43.0 mg, 0.352 mmol). The solution was stirred at rt for 4 h. The solvent was then concentrated. To the resulting residue was added EtOAc (150 mL) and water (50 mL). After separation, the aqueous layer was extracted with EtOAc (2150 mL). The combined organic layers were then washed with water (2100 mL), brine (100 mL), dried (Mg2SO4), and concentrated to yield tert-butyl 3-bromo-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate (2.15 g, 97.5%). LC-MS: (FA) ES+ 314; 1H NMR (Methanol-d4, 300 MHz) delta8.43 (s, 1H, 7.83 (s, 1H), 4.60 (s, 2H), 3.73 (t, J=6.0 Hz, 2H), 2.89 (t, J=6.0 Hz, 2H), 1.48 (s, 9H).
75%	With triethylamine; In dichloromethane; at 20℃;	To a stirred solution of 3-bromo-5,6,7,8-tetrahydro-l,6-naphthyridine (5.00 g, 23.4 mmol, 1.0 eq.) and Di-tert-butyl pyrocarbonate (BOG20, 6.14 g, 28.1 mmol, 1.2 eq.) in (0151) dichloromethane (50 ml) was added triethylamine (2.30 g, 23.4 mmol, 1.0 eq.), and the resultant mixture was stirred at ambient temperature overnight. The reaction mixture was concentrated to dryness, and the crude material was purified by a column chromatography (200-300 mesh silica gel, PE/E A = 5/1) to afford tert-butyl 3-bromo-7,8-dihydro-l,6-naphthyridine-6(5H)-carboxylate (5.50 g, 75% yield) as a colorless oil. 1 HNMR (400 MHz, CDC13) 5(ppm) 8.48 (d, 1H), 7.57 (d, (0152) 1H), 4.59 (s, 2H), 3.75 (t, 2H), 2.96 (t, 2H), 1.50 (s, 9H).

References: [1]Patent: US2012/53201,2012,A1 .Location in patent: Page/Page column 47.
[2]Patent: WO2019/173804,2019,A1 .Location in patent: Paragraph 0106; 0107.

2
[ 67-56-1 ]
[ 201230-82-2 ]
[ 1184950-48-8 ]
[ 1361381-54-5 ]

Yield	Reaction Conditions	Operation in experiment
89.2%		Step 2: 6-t-butyl 3-methyl 7,8-dihydro-1,6-naphthyridine-3,6(5H)-dicarboxylate A solution of <strong>[1184950-48-8]ter<strong>[1184950-48-8]t-butyl 3-bromo-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate</strong></strong> (2.15 g, 6.86 mmol), TEA (9.57 mL, 68.7 mmol), MeOH (25 mL) and DMSO (12.4 mL) was thoroughly degassed with N2 gas for 15 min. Then 1,3-bis(diphenylphosphino)propane (0.442 g, 1.07 mmol) and palladium(II)acetate (0.240 g, 1.07 mmol) were quickly added to the solution. After purging the solution twice with CO gas, the solution was left to stir at 80 C. for 6 h under 1 atm of CO. MeOH was concentrated before EtOAc (400 mL) and water (100 mL) were added to the remaining DMSO residue. After separation, the aqueous phases were extracted with EtOAc (2*300 mL). Then combined organic phases were then washed with brine (100 mL), 1 N HCl (100 mL), dried (MgSO4), and concentrated. Purification via flash column chromatography (EtOAc: hexanes, 1:4 to 1:1) afforded a yellow solid (1.79 g, 89.2%). LC-MS: (FA) ES+ 293; 1H NMR (CDCl3, 400 MHz) delta9.02 (s, 1H), 8.03 (s, 1H), 4.64 (s, 2 H), 3.95 (s, 3H), 3.77 (t, J=6.0 Hz, 2H), 3.07 (t, J=6.0 Hz, 2H), 1.50 (s, 9H).

References: [1]Patent: US2012/53201,2012,A1 .Location in patent: Page/Page column 47.

3
[ 877399-48-9 ]
[ 1184950-48-8 ]
[ 1613148-07-4 ]

Yield	Reaction Conditions	Operation in experiment
49%	With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate; In 1,2-dimethoxyethane; water;Inert atmosphere; Reflux;	To a suspension of (R)-N,N-bis(?ert-butoxycarbonyl)-3-(l-(2,6-dichloro-3- fluorophenyl)ethoxy)-5-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2-yl)pyridin-2-amine (0.56 g, 0.89 mmol), 3-bromo-6-(?ert-butoxycarbonyl)-5,6,7,8-tetrahydro-l,6-naphthyridine (0.2 g, 0.64 mmol) and Cs2C03 (0.62 g, 1.92 mmol) in DME/H20 (15 mL/3 mL) was added Pd(dppf)Cl2-CH2Cl2 (52 mg, 0.06 mmol). The reaction was heated at reflux overnight, then cooled to rt, diluted with H20 (50 mL) and extracted with DCM (50 mL x 3). The combined organic phases were washed with brine (50 mL), dried over anhydrous Na2S04, filtered and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) = 2/1) to give the title compound as a light-yellow solid (0.23 g, 49%). MS (ESI, pos. ion) m/z: 733.2 [M + H]+; NMR (400 MHz, CDC13) delta (ppm): 8.50 (d, J = 1.88 Hz, 1H), 8.23 (d, J = 1.88 Hz, 1H), 7.48 (d, J = 1.60 Hz, 1H), 7.27-7.33 (dd, J= 8.88 Hz, 4.76 Hz, 1H), 7.24 (d, J = 1.76 Hz, 1H), 7.02- 7.08 (t, J= 8.84 Hz, 1H), 6.05-6.12 (q, J = 6.68 Hz, 1H), 4.64 (s, 2H), 3.77 (m, 2H), 3.03 (m, 2H), 1.76-1.84 (d, J= 6.64 Hz, 3H), 1.30-1.55 (m, 27H).
49%	With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; caesium carbonate; In 1,2-dimethoxyethane; water;Inert atmosphere; Reflux;	Under nitrogen protection,A solution of (R) -N, N-bis (tert-butoxycarbonyl) -3- (1- (2,6-dichloro-3-fluorophenyl) ethoxy) -5- (4,4,5, 5-tetramethyl-1,3,2-dioxaborolan-2-yl) pyridin-2-amine (0.56 g, 0.89 mmol)3-bromo-6- (tert-butoxycarbonyl) -5,6,7,8-tetrahydro-1,6-naphthyridine (0.2 g, 0.64 mmol) andCesium carbonate (0.62 g, 1.92 mmol)Was dissolved in a mixture of ethylene glycol dimethyl ether / water (15 mL / 3 mL)To this was added Pd (dppf) Cl2CH2Cl2 (52 mg, 0.06 mmol).The reaction was refluxed overnight, cooled to room temperature, diluted with water (50 mL) and extracted with dichloromethane (50 mL x3).The combined organic phases were washed with brine (50 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate (v / v) = 2/1)The title compound was obtained as a pale yellow solid (0.23 g, 49%).

References: [1]Patent: WO2014/89324,2014,A1 .Location in patent: Paragraph 0293.
[2]Patent: CN104016979,2017,B .Location in patent: Paragraph 0832; 0833; 0834; 0835.

4
[ 877399-48-9 ]
[ 1184950-48-8 ]
[ 1613148-06-3 ]

References: [1]Patent: WO2014/89324,2014,A1 .
[2]Patent: CN104016979,2017,B .

5
[ 24424-99-5 ]
[ 1159010-96-4 ]
[ 1184950-48-8 ]

Yield	Reaction Conditions	Operation in experiment
74%	With sodium hydrogencarbonate; In tetrahydrofuran; methanol; at 0 - 20℃;	To a suspension of 3-bromo-5,6,7,8-tetrahydro-l,6-naphthyridine hydrochloride (2 g, 8.01 mmol) and NaHC03 (2.02 g, 24.04 mmol) in THF/MeOH (60 mL/60 mL) was added (Boc)20 (1.9 mL, 8.82 mmol) at 0 C. The reaction was stirred at rt overnight, and then concentrated in vacuo. The residue was dissolved in H20 (60 mL), and then extracted with EtOAc (60 mL x 3). The combined organic phases were washed with brine (50 mL), dried over anhydrous a2S04, filtered and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) = 8/1) to give the title compound as light-yellow sticky liquid (1.87 g, 74%). MS (ESI, pos. ion) m/z: 313.1 [M + H]+; NMR (400 MHz, CDC13) delta (ppm): 8.46 (m, 1H), 7.55 (m, 1H), 4.56 (s, 2H), 3.72 (m, 2H), 2.93 (m, 2H), 1.47 (s, 9H).

References: [1]Patent: WO2014/89324,2014,A1 .Location in patent: Paragraph 0292.

6
[ 1184950-48-8 ]
[ 1613148-09-6 ]

Yield	Reaction Conditions	Operation in experiment
99%	With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20℃;	To a suspension of 3-bromo-6-(?ert-butoxycarbonyl)-5,6,7,8-tetrahydro-l,6- naphthyridine (0.85 g, 2.71 mmol) in DCM (30 mL) was added m-CPBA (0.56 g, 3.26 mmol). The reaction was stirred at rt overnight, then diluted with DCM (50 mL). The mixture was washed with saturated aqueous a2C03 (40 mL x 2) followed by brine (40 mL), dried over anhydrous a2S04, filtered and concentrated in vacuo. The residue was purified by a silica gel column chromatography (PE/EtOAc (v/v) = 1/1) to afford the title compound as a white solid (0.89 g, 99%). MS (ESI, pos. ion) m/z: 329.0 [M + H]+; NMR (400 MHz, CDC13) delta (ppm): 8.31 (s, 1H), 7.19 (s, 1H), 4.60-4.96 (m, 2H), 4.56 (s, 2H), 3.72 (m, 2H), 2.96 (m, 2H), 1.48 (s, 9H).

References: [1]Patent: WO2014/89324,2014,A1 .Location in patent: Paragraph 0296.

7
[ 1184950-48-8 ]
[ 1613148-10-9 ]

References: [1]Patent: WO2014/89324,2014,A1 .
[2]Patent: CN104016979,2017,B .

8
[ 1184950-48-8 ]
[ 1613148-36-9 ]

References: [1]Patent: WO2014/89324,2014,A1 .
[2]Patent: CN104016979,2017,B .

9
[ 1184950-48-8 ]
[ 1613148-31-4 ]

References: [1]Patent: WO2014/89324,2014,A1 .
[2]Patent: CN104016979,2017,B .

10
[ 1184950-48-8 ]
[ 1613148-54-1 ]

References: [1]Patent: WO2014/89324,2014,A1 .
[2]Patent: CN104016979,2017,B .

11
[ 1184950-48-8 ]
[ 1613148-53-0 ]

References: [1]Patent: WO2014/89324,2014,A1 .
[2]Patent: CN104016979,2017,B .

12
[ 1184950-48-8 ]
[ 1613148-60-9 ]

References: [1]Patent: WO2014/89324,2014,A1 .
[2]Patent: CN104016979,2017,B .

13
[ 1184950-48-8 ]
[ 1613148-59-6 ]

References: [1]Patent: WO2014/89324,2014,A1 .
[2]Patent: CN104016979,2017,B .

14
[ 1184950-48-8 ]
[ 1613148-66-5 ]

References: [1]Patent: WO2014/89324,2014,A1 .
[2]Patent: CN104016979,2017,B .

15
[ 1184950-48-8 ]
3-bromo-8-oxo-6-(tert-butoxycarbonyl)-5,6,7,8-tetrahydro-1,6-naphthyridine [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
99%	With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20℃;	Bromo-6- (tert-butoxycarbonyl) -5,6,7,8-tetrahydro-1,6-naphthyridine (0.85 g, 2.71 mmol)Was suspended in dichloromethane (30 mL)To this was added m-chloroperoxybenzoic acid (0.56 g, 3.26 mmol).The reaction was stirred at room temperature overnight and diluted with dichloromethane (50 mL).The mixture was washed successively with saturated sodium carbonate solution (40 mL x 2), brine (40 mL), anhydrous sulfurSodium sulfate, filtered, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate (v / v) = 1/1) to giveThe title compound was obtained as a white solid (0.89 g, 99%).

References: [1]Patent: CN104016979,2017,B .Location in patent: Paragraph 0846; 0847; 0848; 0849.

16
[ 1184950-48-8 ]
[ 1613148-61-0 ]

References: [1]Patent: CN104016979,2017,B .

17
[ 24424-99-5 ]
3-bromo-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride [ No CAS ]
[ 1184950-48-8 ]

Yield	Reaction Conditions	Operation in experiment
74%	With sodium hydrogencarbonate; In tetrahydrofuran; methanol; at 0 - 20℃;	3-Bromo-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride (2 g, 8.01 mmol) andSodium bicarbonate (2.02 g, 24.04 mmol)Was suspended in a mixture of tetrahydrofuran / methanol (60 mL / 60 mL)The mixture was cooled to 0 C,To this was added Boc anhydride (1.9 mL, 8.82 mmol).The reaction mixture was stirred at room temperature overnight and concentrated under reduced pressure. The residue was dissolved in water (60 mL / 60 mL) and extracted with ethyl acetate (60 mL x 3). The combined organic phases were washed with brine (50 mL), dried over anhydrous sodium sulfate,Filtered and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (petroleum ether / ethyl acetate (v / v) = 8/1)The title compound was obtained as a pale yellow viscous liquid (1.87 g, 74%).

References: [1]Patent: CN104016979,2017,B .Location in patent: Paragraph 0828; 0829; 0830; 0831.

18
[ 79099-07-3 ]
[ 1184950-48-8 ]

References: [1]Patent: EP3248968,2017,A1 .

19
[ 355818-98-3 ]
[ 1184950-48-8 ]

References: [1]Patent: EP3248968,2017,A1 .

20
[ 355819-02-2 ]
[ 1184950-48-8 ]

Yield	Reaction Conditions	Operation in experiment
	With tert.-butylnitrite; copper(ll) bromide; In acetonitrile; at 0 - 20℃; for 16h;	Step C: CuBr2 (402.03 mg, 1.8 mmol, 1.5 eq.) was added to a solution of t-butyl 3-amino-7,8-dihydro-5H-1,6-naphthyridine-6-carboxylate (300 mg, 1.2 mmol, 1 eq.) in acetonitrile (6 mL) at room temperature, followed bydropwise adding t-butyl nitrite (148.49 mg, 1.44 mmol, 1.2 eq.) at 0-5C to react for 1 hour. The temperature wasraised to room temperature with stirring for 15 hours. The reaction solution was poured into water (20 mL), filtered,and extracted three times with each 20 mL of ethyl acetate. The organic phase was washed twice with 30 mL ofwater each time, dried over anhydrous sodium sulfate, filtrated and concentrated to give a crude product. The crude product was purified by a silica gel chromatography column (PE/EA = 10/1 to 3/1) to give t-butyl 3-bromo-7,8-dihydro-5H-1,6-naphthyridine-6-carboxylate (180 mg, 534.5 mmol, 44.54% yield, 93% of purity) as a colorless and transparentoil.

References: [1]Patent: EP3248968,2017,A1 .Location in patent: Paragraph 0092.

21
[ 1184950-48-8 ]
t-butyl 3-[5-(2,4-dibenzyloxy-5-isopropylphenyl)-3-(ethylcarbamoyl)isoxazol-4-yl]-7,8-dihydro-5H-1,6-naphthyridine-6-carboxylate [ No CAS ]

References: [1]Patent: EP3248968,2017,A1 .

22
[ 1184950-48-8 ]
5-(2,4-dibenzyloxy-5-isopropylphenyl)-N-ethyl-4-(5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)isoxazole-3-carboxamide [ No CAS ]

References: [1]Patent: EP3248968,2017,A1 .

23
[ 1184950-48-8 ]
5-(2,4-dibenzyloxy-5-isopropylphenyl)-N-ethyl-4-(6-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)isoxazole-3-carboxamide [ No CAS ]

References: [1]Patent: EP3248968,2017,A1 .

24
[ 1184950-48-8 ]
5-(2,4-dihydroxyl-5-isopropylphenyl)-N-ethyl-4-(6-methyl-5,6,7,8-tetrahydro-1,6-naphthyridin-3-yl)isoxazole-3-carboxamide formate [ No CAS ]

References: [1]Patent: EP3248968,2017,A1 .

25
[ 1184950-48-8 ]
[ 73183-34-3 ]
t-butyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-7,8-dihydro-5H-1,6-naphthyridine-6-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
	With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; potassium acetate; In 1,4-dioxane; at 25 - 100℃; for 16h;Inert atmosphere;	Step D: Bis(pinacolato)diboron (194.60 mg, 766.31 mmol, 1.50 eq.) and KOAc (150.41 mg, 1.53 mmol, 3 eq.) wereadded to a solution of <strong>[1184950-48-8]t-butyl 3-bromo-7,8-dihydro-5H-1,6-naphthyridine-6-carboxylate</strong> (160 mg, 510.87 mmol, 1 eq.)in dioxane (3 mL) at 25C under the protection of nitrogen gas, followed by the addtion of a catalystPd(dppf)Cl2·CH2Cl2 (74.76 mg, 102.17 mmol, 0.20 eq.). The mixture was stirred at 25C for 10 min, and then heatedto 100C with stirring for 16 hours. The mixture was cooled down to 25C and concentrated under reduced pressureto give a crude product, which was used directly in the next step

References: [1]Patent: EP3248968,2017,A1 .Location in patent: Paragraph 0092.

26
[ 1184950-48-8 ]
tert-butyl 3-bromo-5-oxo-7,8-dihydro-1,6-naphthyridine-6(5H)-carboxylate [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
84%	With ruthenium trichloride; sodium periodate; In water; ethyl acetate; at 20℃;	To a stirred mixture of RuCl3 (0.40 g, 1.91 mmol, 0.15 eq.) and NaI04 (12.84 g, 60.0 mmol, 4.7 eq.) in H20/EA (80 ml/80 ml) was added a solution of tert-butyl (0155) 3-bromo-7, 8-dihydro- l,6-naphthyridine-6(5H)-carboxylate (4.00 g, 12.8 mmol, 1.0 eq.) in EA (40 ml), and the resultant mixture was stirred at ambient temperature overnight. Organic phase was separated, washed with brine, dried over Na2S04, and was concentrated to dryness. The crude material was purified by a column chromatography (200-300 mesh silica gel, PE/EA = 5/1) to afford tert-butyl 3-bromo-5-oxo-7,8-dihydro-l,6-naphthyridine-6(5H)-carboxylate (3.70 g, 84% yield) as a white solid.?HNMR (400 MHz, CDCl3) 5(ppm) 8.71 (d, 1H), 8.54 (d, 1H), 4.07 (t, (0156) 2H), 3.17 (t, 2H), 1.59 (s, 9H).

References: [1]Patent: WO2019/173804,2019,A1 .Location in patent: Paragraph 0106; 0108; 0109.

27
[ 1184950-48-8 ]
3-bromo-7,8-dihydro-1,6-naphthyridin-5(6H)-one [ No CAS ]

References: [1]Patent: WO2019/173804,2019,A1 .

28
[ 1184950-48-8 ]
3-bromo-6-(oxiran-2-ylmethyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one [ No CAS ]

References: [1]Patent: WO2019/173804,2019,A1 .

29
[ 1184950-48-8 ]
3-bromo-6-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-7,8-dihydro-1,6-naphthyridin-5(6H)-one [ No CAS ]

References: [1]Patent: WO2019/173804,2019,A1 .

30
[ 1184950-48-8 ]
6-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-3-(oxetan-3-ylamino)-7,8-dihydro-1,6-naphthyridin-5(6H)-one [ No CAS ]

References: [1]Patent: WO2019/173804,2019,A1 .

Historical Records

Technical Information

• Acyl Group Substitution • Alkyl Halide Occurrence • Chan-Lam Coupling Reaction • Complex Metal Hydride Reductions • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Hydride Reductions • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Lawesson's Reagent • Preparation of Amines • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Dihalides • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling

Precautionary Statements-General
Code	Phrase
P101	If medical advice is needed,have product container or label at hand.
P102	Keep out of reach of children.
P103	Read label before use
Prevention
Code	Phrase
P201	Obtain special instructions before use.
P202	Do not handle until all safety precautions have been read and understood.
P210	Keep away from heat/sparks/open flames/hot surfaces. - No smoking.
P211	Do not spray on an open flame or other ignition source.
P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
P233	Keep container tightly closed.
P234	Keep only in original container.
P235	Keep cool
P240	Ground/bond container and receiving equipment.
P241	Use explosion-proof electrical/ventilating/lighting/equipment.
P242	Use only non-sparking tools.
P243	Take precautionary measures against static discharge.
P244	Keep reduction valves free from grease and oil.
P250	Do not subject to grinding/shock/friction.
P251	Pressurized container: Do not pierce or burn, even after use.
P260	Do not breathe dust/fume/gas/mist/vapours/spray.
P261	Avoid breathing dust/fume/gas/mist/vapours/spray.
P262	Do not get in eyes, on skin, or on clothing.
P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

{[proInfo.proName]}

CAS No.: 1184950-48-8

{[proInfo.proName]}

CAS No.: 1184950-48-8

Alternative Products

Product Details of [ 1184950-48-8 ]

Safety of [ 1184950-48-8 ]

Application In Synthesis of [ 1184950-48-8 ]

[ 1184950-48-8 ] Synthesis Path-Downstream 1~30

Related Products

Historical Records

Technical Information

Categories

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator