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Chemical Structure| 34403-46-8 Chemical Structure| 34403-46-8

Structure of 34403-46-8

Chemical Structure| 34403-46-8

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Product Details of [ 34403-46-8 ]

CAS No. :34403-46-8
Formula : C8H12ClNO
M.W : 173.64
SMILES Code : OCC1=CC=C(CN)C=C1.[H]Cl
MDL No. :MFCD06213766

Safety of [ 34403-46-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P233-P260-P261-P264-P271-P280-P302+P352-P304-P304+P340-P305+P351+P338-P312-P321-P332+P313-P337+P313-P340-P362-P403-P403+P233-P405-P501

Application In Synthesis of [ 34403-46-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 34403-46-8 ]

[ 34403-46-8 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 123986-64-1 ]
  • [ 34403-46-8 ]
YieldReaction ConditionsOperation in experiment
With hydrogenchloride; In 1,4-dioxane; at 50℃; for 1h; Preparation 181 4-(aminomethyl)phenylmethanol hydrochloride Add 4N hydrogen chloride in 1,4-dioxane (25 mL) to a solution of <strong>[123986-64-1](4-hydroxymethyl-benzyl)-carbamic acid tert-butyl ester</strong> (3.0 g, 12.6 mmol) in 1,4-dioxane (25 mL). Heat the reaction mixture at 50° C. for 1 hr. Filter the solid and wash it with ethyl acetate to give the title compound (2.1 g, 12.1 mmol).
  • 2
  • [ 34403-46-8 ]
  • [ 41716-18-1 ]
  • [ 1204738-81-7 ]
YieldReaction ConditionsOperation in experiment
Preparation 182 N-(4-(Hydroxymethyl)benzyl)-1-methyl-1H-imidazole-4-carboxamide Stir a mixture of <strong>[41716-18-1]1-<strong>[41716-18-1]methyl-1H-imidazole-4-carboxylic acid</strong></strong> (4.0 g, 31.67 mmol), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (6.6 g, 34.5 mmol) and 1-hydroxybenzotriazole hydrate (5.29 g, 34.5 mmoles) in anhydrous acetonitrile (150 mL) at room temperature for 1 hr. Add to the reaction mixture (4-aminomethyl-phenyl)-methanol hydrochloride (5.0 g, 28.8 mmol) and triethylamine (8.4 mL, 60.5 mmol). Stir the reaction mixture at room temperature overnight. Quench the reaction mixture with water and extract with ethyl acetate (3*). Combine the organic layers, wash with brine, dry over sodium sulfate, and concentrate to provide the title compound (4.6 g, 18.8 mmol). MS (m/z): 246 (M+1).
  • 3
  • [ 71831-21-5 ]
  • [ 34403-46-8 ]
 

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