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Chemical Structure| 33842-02-3 Chemical Structure| 33842-02-3
Chemical Structure| 33842-02-3

N-(Dichloromethylene)-N-methylmethanaminium chloride

CAS No.: 33842-02-3

4.5 *For Research Use Only !

Cat. No.: A635054 Purity: 95%

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Product Details of [ 33842-02-3 ]

CAS No. :33842-02-3
Formula : C3H6Cl3N
M.W : 162.45
SMILES Code : C[N+](C)=C(Cl)Cl.[Cl-]
MDL No. :MFCD00011870

Safety of [ 33842-02-3 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314-H335
Precautionary Statements:P261-P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 33842-02-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 33842-02-3 ]

[ 33842-02-3 ] Synthesis Path-Downstream   1~5

  • 1
  • [ 603-87-2 ]
  • [ 33842-02-3 ]
  • [ 43183-94-4 ]
  • 2
  • [ 13589-72-5 ]
  • [ 33842-02-3 ]
  • (4,6-Dichloro-benzo[e][1,3]oxazin-2-ylidene)-dimethyl-ammonium; chloride [ No CAS ]
  • 3
  • [ 33842-02-3 ]
  • [ 158001-28-6 ]
  • 1-tert-butyl-5-[chloro(dimethylamino)methyleneamino]-4-cyano-1H-pyrazole [ No CAS ]
  • 4
  • [ 89415-54-3 ]
  • [ 33842-02-3 ]
  • [ 1257553-97-1 ]
YieldReaction ConditionsOperation in experiment
In 1-methyl-pyrrolidin-2-one; at 20℃; for 17h; A solution of 5-bromo-N*2*-methyl-pyridine-2,3-diamine (Stage 67,1.4, 2 09 g 10 34 mrnol) and dichloromethylene-dimethyliminium chloride (Aldrich, Buchs, Switzerland 5 04 g, 31 0 mmol) in NMP (60 ml) was stirred for 17 h at rt The reaction mixture was quenched with saturated aqueous NaHCO3 and EtOAc The aqueous layer was extracted with EtOAc and the combined organic layers washed with saturated aqueous NaHCO3 and with brine, then dned over Na2SO4, filtered and evaporated The crude product was dry loaded on silica gel and pu?fied by MPLC (DCM/MeOH 0% ? 5%) to give the title compound as a red solid (HPLC t« 2 13 mm (Method A). M+H - 255, 257 MS-ES)
  • 5
  • [ 15351-42-5 ]
  • [ 33842-02-3 ]
  • [ 13969-01-2 ]
YieldReaction ConditionsOperation in experiment
79% In acetonitrile; for 2.0h;Reflux; Dibenzo[b,f][1,5]diazocine-6,12-dione (2.38 g, 10.0 mmol) and dichloromethylene-dimethyl-iminium chloride, Viehe's reagent (3.25 g, 20.0 mmol) were heated at reflux temperature in acetonitrile (50 mL) for 2 h. After concentration methanol (35 mL) was added, which soon resulted in crystallization of the product (2.20g, 79%), mp 180-181 C (lit.40 mp 177-178 C); 13C NMR (DMSO-d6): 29.9 (q), 118.3 (s), 118.5 (s), 120.8 (d), 125.1 (d), 125.6 (d), 126.7 (d), 127.0 (d), 127.3 (d), 133.6 (d), 135.3 (d), 135.6 (s), 145.4 (s), 159.2 (s), 161.5 (s).
 

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