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Chemical Structure| 33619-33-9 Chemical Structure| 33619-33-9

Structure of 33619-33-9

Chemical Structure| 33619-33-9

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Product Details of [ 33619-33-9 ]

CAS No. :33619-33-9
Formula : C9H16Cl2N2O2
M.W : 255.14
SMILES Code : O=C(NCCCCCNC(CCl)=O)CCl
MDL No. :MFCD00455513
InChI Key :YHXXCHVUPKCXGH-UHFFFAOYSA-N
Pubchem ID :246195

Safety of [ 33619-33-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H301-H311-H331-H341
Precautionary Statements:P201-P202-P261-P264-P270-P271-P280-P302+P352-P304+P340-P308+P313-P310-P330-P361-P403+P233-P405-P501
Class:6.1
UN#:2811
Packing Group:

Application In Synthesis of [ 33619-33-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 33619-33-9 ]

[ 33619-33-9 ] Synthesis Path-Downstream   1~8

  • 3
  • [ 33619-33-9 ]
  • [ 333-20-0 ]
  • 2,2'-bis-thiocyanato-<i>N</i>,<i>N</i>'-pentane-1,5-diyl-bis-acetamide [ No CAS ]
  • 7
  • [ 2465-65-8 ]
  • [ 33619-33-9 ]
  • [ 1416234-03-1 ]
YieldReaction ConditionsOperation in experiment
24.3% With potassium; In methanol; for 16.0h;Reflux; General procedure: To a solution of O,O,-diethylthiophosphate, potassium (3) (2.18 g, 10.5 mmol) in methanol (20.0 ml), N′,N′-(ethane-1,2-diyl) bis(2-chloroacetamide) (2A) (1.06 g, 5.0, mmol) was added, and the mixture was refluxed for 16 h. The reaction mixture was filtered and the filtrate was concentrated under vacuum. The viscous residue was dissolved with 20 ml ethyl acetate, then washed with water and the ethyl acetate layer was dried over anhydrous sodium sulfate. The dried solution was concentrated under reduced pressure, the crude compound was chromatographed on silica gel to give S′,S′-2,2-(ethane-1,2-diylbis(azanediyl)) bis(2-oxoethane-2,1-diyl) O,O,O′,O′-tetraethyl diphosphorodithioate (4A). The same procedure was employed in the preparation of the products 4A-I by using the corresponding N′,N′-(alkane-α,ω-diyl) bis(2-chloroacetamide).
  • 8
  • [ 462-94-2 ]
  • [ 96-34-4 ]
  • [ 33619-33-9 ]
YieldReaction ConditionsOperation in experiment
In methanol; at 20.0℃; for 10.0h; General procedure: To a solution of methyl 2-chloroacetate (13.0 g, 120.0 mmol) in methanol (20.0 ml), ethane-1, 2-diamine (1A) (3.0 g, 50.0 mmol) of methanol was added dropwise at room temperature, and stirred for 10 h. The white solid was filtered, washed, dried and collected. The solution was condensed and cooled to crystallize the residual product. The leading white solid was washed, dried and collected. Two products were combined to get N′,N′-(ethane-1, 2-diyl) bis(2-chloroacetamide) (2A). The same procedure was employed in the preparation of the products 2B-I by using the corresponding alkane diamine.
 

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