32620-90-9|3a,4,7,7a-Tetrahydro-2-(2'-hydroxyethyl)-4,7-epoxy-1H-isoindole-1,3(2H)-dione| Ambeed

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CAS No. :	32620-90-9
Formula :	C₁₀H₁₁NO₄
M.W :	209.20
SMILES Code :	O=C1N(CCO)C(C2C(O3)C=CC3C12)=O
MDL No. :	MFCD08274857
InChI Key :	ISKZEUQQPPVQNW-UHFFFAOYSA-N
Pubchem ID :	12193800

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319
Precautionary Statements:	P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362

Yield	Reaction Conditions	Operation in experiment
93%	With 1,4-dimethoxybezene; In xylene; at 130℃; for 3.25h;Heating / reflux;	A 0.19 mol (4Og) sample of the HEMI-A from above was mixed with 227g of xylene and 0.005g methyl hydroquinone (MEHQ), an antioxidant. After heating under reflux and nitrogen sparging for 3 hours 15 minutes at 1300C, the conversion of HEMI-A to HEMI reached 98.7% and the reaction yield was determined to be approximately 98.7%. The reactor was cooled to room temperature, and the cooled reaction product was filtered at room temperature, and the filtered solids were washed with 15g of xylenes. The washed solids were dried under vacuum, and 25. Ig of HEMI, a 93% yield based on the HEMI-A, was obtained. The purity of the HEMI was determined to be greater than 99% by H-NMR. It was EPO <DP n="13"/>also determined that the mother liquor and wash liquid was combined and determined to weigh 230.2g and contain 1.17g of HEMI, which could be recovered as described above, or recycled.
81%	In toluene; for 7h;Reflux;	The synthesis of 1-(2-Hydroxyethyl)-1H-pyrrole-2,5-dione (5) was carried out following methods reported in a previous publication [43]. In a 50mL round-bottom flask adapted with a flux condenser and magnetic stirring, the intermediate 4 (2.30g, 10.99mmol) was combined with toluene (30mL). The reaction was refluxed for 7h. The resulting mixture was immediately filtered, and the product crystallised from toluene in 81% yield (1.25g, 8.87mmol). 1H-NMR (400MHz, DMSO-d6) delta 7.01 (s, 2H), 4.78 (br, 1H), 3.46 (br, 4H); 13C-NMR (100MHz, DMSO-d6) delta 171.1, 134.5, 57.9, 39.9.
	In toluene; for 12h;Reflux; Inert atmosphere;	General procedure: N-(2-hydroxyethyl)maleimide (Mal-OH) was prepared according to a previously reported method [3, 34]. Firstly, 30.0 g maleic anhydride (306mmol)was dissolved in toluene and 22.4 ml furan (309mmol) was slowly injected into the solution via syringe. After the mixture stirred for 24 h at room temperature, the reaction was stopped and the white crystals were precipitated from the mixture, collected and washed with toluene. The white powder was dried in a vacuum oven to prepare furan-protected maleic anhydride. Secondly, the furan-protected maleic anhydride(4.98 g, 30mmol) was suspended in methanol and stirred at 0 C. Then1.8 ml of ethanolamine (30mmol) was added dropwise to the solution,stirred and refluxed at 80 C for 24 h. Then the reaction mixture was cooled to 0 C, the product was crystallized from the mixture and collected to obtain furan-protected N-(2-hydroxyethyl)-maleimide. Finally,furan-protected N-(2-hydroxyethyl)-maleimide (2.1 g, 10mmol) in 10 ml toluene was stirred and refluxed under nitrogen for 12 h. The reaction mixture was hot filtered, and the filtrate was stored at 4 C overnight.The product crystallized from the mixture, then collected, dried under vacuum for 24 h to obtain N-(2-hydroxyethyl)-maleimide (Mal-OH)

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Code	Phrase
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P220	Keep/Store away from clothing/combustible materials.
P221	Take any precaution to avoid mixing with combustibles
P222	Do not allow contact with air.
P223	Keep away from any possible contact with water, because of violent reaction and possible flash fire.
P230	Keep wetted
P231	Handle under inert gas.
P232	Protect from moisture.
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P234	Keep only in original container.
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P240	Ground/bond container and receiving equipment.
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P263	Avoid contact during pregnancy/while nursing.
P264	Wash hands thoroughly after handling.
P265	Wash skin thouroughly after handling.
P270	Do not eat, drink or smoke when using this product.
P271	Use only outdoors or in a well-ventilated area.
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P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
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Code	Phrase
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P378
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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
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P401
P402	Store in a dry place.
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Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

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CAS No.: 32620-90-9

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CAS No.: 32620-90-9

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[ 32620-90-9 ] Synthesis Path-Downstream 1~1

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Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed