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Chemical Structure| 32122-23-9 Chemical Structure| 32122-23-9
Chemical Structure| 32122-23-9

1-Bromocyclobutane-1-carboxylic acid

CAS No.: 32122-23-9

4.5 *For Research Use Only !

Cat. No.: A758433 Purity: 98%

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Product Details of [ 32122-23-9 ]

CAS No. :32122-23-9
Formula : C5H7BrO2
M.W : 179.01
SMILES Code : O=C(C1(Br)CCC1)O
MDL No. :MFCD08861855
InChI Key :YREQYUFYDFSXJC-UHFFFAOYSA-N
Pubchem ID :301573

Safety of [ 32122-23-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H302-H314
Precautionary Statements:P261-P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 32122-23-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 32122-23-9 ]

[ 32122-23-9 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 67-56-1 ]
  • [ 32122-23-9 ]
  • [ 51175-79-2 ]
YieldReaction ConditionsOperation in experiment
With sulfuric acid; at 20℃; for 2h;Inert atmosphere; To a solution of 1-bromocyclobutanecarboxylic acid (C) (17.40 g, 97.75 mmol) in MeOH (120 mL) was added concentrated H2S04 (2 mL) dropwise at r.t.. After addition, the mixture was warmed to 65C for 2 h. The reaction was cooled to r.t. and added H20 (250 ml), extracted with PE/EtOAc (1:1) (2 x 150 mL), combine the organic layer, washed with H20 (200 ml), brine (250 mL), dried over Na2SO4 and concentrated to give the crude product of methyl 1 -bromocyclobutane-1 -carboxylate (D), which was used for next step directly.
  • 2
  • [ 51175-79-2 ]
  • [ 32122-23-9 ]
YieldReaction ConditionsOperation in experiment
With water; sodium hydroxide; In methanol; at 20℃; for 2h; To a solution of <strong>[51175-79-2]methyl 1-bromocyclobutane-1-carboxylate</strong> (192 mg, 1.00 mmol) in MeOH (4 mL) was added aqueous NaOH (2M, 1 mL) at rt and the mixture was stirred for 2 h. Water (20 mL) was added and the mixture was extracted with EtOAc (2 x 20 mL). The combined organic layers were washed with brine (20 mL), dried over Na2S04, filtered and concentrated to to dryness to give the title compound as a yellow solid.
 

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