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Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 3212-75-7 Chemical Structure| 3212-75-7

Structure of Cyclooct-2-enol
CAS No.: 3212-75-7

Chemical Structure| 3212-75-7

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Product Citations

Product Citations

Chen, Jing ; Ji, Peng ; Gnawali, Giri ; Chang, Mengyang ; Gao, Feng ; Xu, Hang , et al.

Abstract: The current targeting drug delivery mainly relies on cancer cell surface receptors. However, in many cases, binding affinities between protein receptors and homing ligands is relatively low and the expression level between cancer and normal cells is not significant. Distinct from conventional targeting strategies, we have developed a general cancer targeting platform by building artificial receptor on cancer cell surface via a chemical remodeling of cell surface glycans. A new tetrazine (Tz) functionalized chemical receptor has been designed and efficiently installed on cancer cell surface as "overexpressed" biomarker through a metabolic glycan engineering. Different from the reported bioconjugation for drug targeting, the tetrazine labeled cancer cells not only locally activate TCO-caged prodrugs but also release active drugs via the unique bioorthogonal Tz-TCO click-release reaction. The studies have demonstrated that the new drug targeting strategy enables local activation of prodrug, which ultimately leads to effective and safe cancer therapy.

Keywords: Artificial receptor ; Click and release ; Local activation ; Protein degradation

Alternative Products

Product Details of [ 3212-75-7 ]

CAS No. :3212-75-7
Formula : C8H14O
M.W : 126.20
SMILES Code : OC1C=CCCCCC1
MDL No. :MFCD00128153
InChI Key :UJZBDMYKNUWDPM-XQRVVYSFSA-N
Pubchem ID :5380758

Safety of [ 3212-75-7 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H302-H312-H332
Precautionary Statements:P210-P233-P240-P241-P242-P243-P261-P264-P270-P271-P280-P301+P312-P302+P352-P303+P361+P353-P304+P340-P330-P363-P370+P378-P403+P235-P501
Class:3
UN#:1987
Packing Group:
 

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