[ CAS No. 320-50-3 ] 1,4-Dichloro-2-(trifluoromethyl)benzene

Cat. No.: A1475703

2D 3D

Structure of 320-50-3 * Storage: Sealed in dry,Room Temperature

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* Storage: Sealed in dry,Room Temperature

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Quality Control of [ 320-50-3 ]

COA NMR CNMR HPLC LC-MS

Related Doc. of [ 320-50-3 ]

Specification

Alternatived Products of [ 320-50-3 ]

Product Details of [ 320-50-3 ]

CAS No. :	320-50-3	MDL No. :	MFCD00000608
Formula :	C₇H₃Cl₂F₃	Boiling Point :	-
Linear Structure Formula :	-	InChI Key :	DYBYUWVMLBBEMA-UHFFFAOYSA-N
M.W :	215.00	Pubchem ID :	35360
Synonyms :

Safety of [ 320-50-3 ]

Signal Word:	Warning	Class:	N/A
Precautionary Statements:	P261-P280-P301+P312-P302+P352-P305+P351+P338	UN#:	N/A
Hazard Statements:	H302-H315-H319-H335	Packing Group:	N/A
GHS Pictogram:

Application In Synthesis of [ 320-50-3 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 320-50-3 ]
Downstream synthetic route of [ 320-50-3 ]

[ 320-50-3 ] Synthesis Path-Upstream 1~4

1
[ 98-08-8 ]
[ 328-84-7 ]
[ 320-50-3 ]
[ 54773-20-5 ]
[ 54773-19-2 ]
[ 98-15-7 ]

Reference： [1] Journal of Organic Chemistry USSR (English Translation), 1985, vol. 21, p. 734 - 740[2] Zhurnal Organicheskoi Khimii, 1985, vol. 21, # 4, p. 809 - 817

2
[ 98-15-7 ]
[ 328-84-7 ]
[ 320-50-3 ]
[ 54773-20-5 ]
[ 54773-19-2 ]

Reference： [1] Journal of Organic Chemistry USSR (English Translation), 1985, vol. 21, p. 734 - 740[2] Zhurnal Organicheskoi Khimii, 1985, vol. 21, # 4, p. 809 - 817

3
[ 98-08-8 ]
[ 328-84-7 ]
[ 320-50-3 ]
[ 50594-82-6 ]
[ 54773-20-5 ]
[ 54773-19-2 ]
[ 61841-47-2 ]

Reference： [1] Journal of Organic Chemistry USSR (English Translation), 1985, vol. 21, p. 734 - 740[2] Zhurnal Organicheskoi Khimii, 1985, vol. 21, # 4, p. 809 - 817

4
[ 98-15-7 ]
[ 328-84-7 ]
[ 320-50-3 ]
[ 56148-83-5 ]
[ 50594-82-6 ]
[ 54773-19-2 ]
[ 61841-46-1 ]

Reference： [1] Journal of Organic Chemistry USSR (English Translation), 1985, vol. 21, p. 734 - 740[2] Zhurnal Organicheskoi Khimii, 1985, vol. 21, # 4, p. 809 - 817

Yield	Reaction Conditions	Operation in experiment
	With hydrogenchloride; potassium hydroxide; In dimethyl sulfoxide; tert-butyl alcohol;	EXAMPLE 8 4-Chloro-2-trifluoromethylphenol To a 300 ml, 3-necked flask fitted with a stirrer, condenser, thermometer and drying tube is added dimethylsulfoxide (100 ml), tert-butanol (20 ml), powdered potassium hydroxide (KOH) pellets (85%, 30 g) and <strong>[320-50-3]2,5-<strong>[320-50-3]dichlorobenzotrifluoride</strong></strong> (21.5 g, 0.10 mole). The reaction mixture is warmed to 71-73 C. for 60 hours, then additional KOH (10 g) is added and heating is continued at 73-75 C. for 24 hours. The reaction mixture is cooled and the solvent partially removed by distillation at 0.9 mm, bp 55 C.). The cooled pot residue is then poured into ice water (1000 g) which had been preacidified to pH 1 with conc. HCl (50 ml). The aqueous mixture is extracted with carbon tetrachloride (CCl4), the CCl4 layer decanted and dried and the solvent removed under vacuum to afford 10.8 g of 4-chloro-2-trifluoromethylphenol, which is sublimed to afford pure product, mp 81-81.5 C. Elemental Anal. Calcd for C7 H4 ClF3 O: C, 42.75; H, 2.06; Cl, 18.04: Found: C, 42.54; H, 2.36; Cl, 18.16. STR14

Yield	Reaction Conditions	Operation in experiment
12.1 g	With pyridine; hydrazine hydrate; In dichloromethane; ethyl acetate; at 130.0℃; for 4.0h;Autoclave;	Take 2,5-dichloro-3-trifluoromethylbenzene 6 (15.4 g) in an autoclave,Hydrazine hydrate (26g) and pyridine (150ml) were added together with ethyl acetate and methylene chloride (250ml) as organic solvents. The mixture was heated to 130C and reacted for 4 hours. After cooling, excess hydrazine was removed, vacuum distillation was performed, and the residue was added with solvent petroleum. The ether is recrystallized to give 2-chloro-3-trifluoromethylphenylhydrazine 7 (12.1 g)

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Isomers

Technical Information

• Alkyl Halide Occurrence • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling

Historical Records

Related Functional Groups of
[ 320-50-3 ]

Chlorides

[ 74483-46-8 ]

2-Chloro-4-methyl-1-(trifluoromethyl)benzene

Similarity: 0.98

[ 328-72-3 ]

3,5-Bis(trifluoromethyl)chlorobenzene

Similarity: 0.95

[ 54773-20-5 ]

1,3-Dichloro-5-(trifluoromethyl)benzene

Similarity: 0.93

[ 43141-66-8 ]

1-Chloro-4-(difluoromethyl)benzene

Similarity: 0.90

[ 50594-82-6 ]

3,4,5-Trichlorobenzotrifluoride

Similarity: 0.85

Trifluoromethyls

[ 74483-46-8 ]

2-Chloro-4-methyl-1-(trifluoromethyl)benzene

Similarity: 0.98

[ 328-72-3 ]

3,5-Bis(trifluoromethyl)chlorobenzene

Similarity: 0.95

[ 54773-20-5 ]

1,3-Dichloro-5-(trifluoromethyl)benzene

Similarity: 0.93

[ 50594-82-6 ]

3,4,5-Trichlorobenzotrifluoride

Similarity: 0.85

[ 54773-19-2 ]

1,2-Dichloro-3-(trifluoromethyl)benzene

Similarity: 0.83

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P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
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Yield	Reaction Conditions	Operation in experiment
		Similarly, 4-(2-trifluoromethyl-4-chlorophenoxy)benzene is prepared by following the same procedure but using <strong>[320-50-3]1,4-dichloro-2-trifluoromethylbenzene</strong> in place of 1,2-dichloro-4-trifluoromethylbenzene.
		Similarly, 4-(2-trifluoromethyl-4-chlorophenoxy)benzene is prepared by following the same procedure but using <strong>[320-50-3]1,4-dichloro-2-trifluoromethylbenzene</strong> in place of 1,2-dichloro-4-trifluoromethylbenzene.

[ CAS No. 320-50-3 ] 1,4-Dichloro-2-(trifluoromethyl)benzene

Quality Control of [ 320-50-3 ]

Related Doc. of [ 320-50-3 ]

Product Details of [ 320-50-3 ]

Safety of [ 320-50-3 ]

Application In Synthesis of [ 320-50-3 ]

[ 320-50-3 ] Synthesis Path-Upstream 1~4

[ 320-50-3 ] Synthesis Path-Downstream 1~21

Technical Information

Related Functional Groups of [ 320-50-3 ]

Chlorides

Trifluoromethyls

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Related Functional Groups of
[ 320-50-3 ]