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Chemical Structure| 30263-65-1 Chemical Structure| 30263-65-1

Structure of 30263-65-1

Chemical Structure| 30263-65-1

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Product Details of [ 30263-65-1 ]

CAS No. :30263-65-1
Formula : C6H10Br2O
M.W : 257.95
SMILES Code : O=C(C(C)(C)C)C(Br)Br
MDL No. :MFCD00045030
InChI Key :WIPDATICDHNWKG-UHFFFAOYSA-N
Pubchem ID :34866

Safety of [ 30263-65-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 30263-65-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 30263-65-1 ]

[ 30263-65-1 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 30263-65-1 ]
  • [ 2582-30-1 ]
  • [ 937-02-0 ]
  • 6-<i>tert</i>-butyl-[1,2,4]triazin-3-ylamine [ No CAS ]
  • 2
  • [ 30263-65-1 ]
  • [ 1937-19-5 ]
  • [ 937-02-0 ]
  • 6-<i>tert</i>-butyl-[1,2,4]triazin-3-ylamine [ No CAS ]
  • 4
  • [ 30263-65-1 ]
  • [ 2582-30-1 ]
  • [ 937-02-0 ]
YieldReaction ConditionsOperation in experiment
[130] Step 2. 5-(tert-Butviyi.2,4-triazin-3-arnine (17-dO): Aminoguanidine bicarbonate (4.75 g, 34.9 mmol) was suspended in methanol (25 mL). Acetic acid (6 mL, 104.7 mmol) was added dropwise and the solution was stirred at room temperature overnight.In a separate flask 47 (9.00 g, 34.9 mmol) was dissolved in THF (50 mL). The solution was heated to 45 0C and morpholine (12.2 mL, 139.5 mmol) was added dropwise. The reaction was heated at 65-70 0C and stirred overnight. An evaporated aliquot was checked by NMR to ensure complete consumption of starting material. The reaction was cooled and the solids were removed by filtration and washed with THF. The filtrate was concentrated, then twice dissolved in methanol (2 x 50 mL) and reconcentrated. Finally, the material was dissolved in fresh methanol (50 mL). The previously prepared MeOH solution of aminoguanidine acetate was added slowly over 30 min. The reaction was stirred at room temperature over a weekend. Some starting material remained by GCMS. The reaction was heated at 45-50 0C overnight. The mixture was cooled and concentrated to one-half volume. Water (50 mL) and heptane (25 mL) were added with vigorous stirring. The layers were separated and the heptane layer was checked for product and discarded. The aqueous mixture was further concentrated to remove residual methanol, then was cooled in an ice bath. The product was isolated by filtration and washed with cold water. Drying provided 2.0 g (38%) of 17-dO as a light yellow solid. Approximately 10% of a side product was visible by NMR. The material was carried forward to the next reaction.
 

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