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Chemical Structure| 26272-85-5 Chemical Structure| 26272-85-5
Chemical Structure| 26272-85-5

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Product Details of 3-Iodooxetane

CAS No. :26272-85-5
Formula : C3H5IO
M.W : 183.98
SMILES Code : IC1COC1
MDL No. :MFCD08544403
InChI Key :KBEIFKMKVCDETC-UHFFFAOYSA-N
Pubchem ID :13356686

Safety of 3-Iodooxetane

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H225-H315-H319-H335
Precautionary Statements:P242-P261-P264-P271-P280-P304+P340-P305+P351+P338-P312-P363-P370+P378-P403+P233-P501
Class:3
UN#:1993
Packing Group:

Application In Synthesis of 3-Iodooxetane

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 26272-85-5 ]

[ 26272-85-5 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 26272-85-5 ]
  • [ 22300-52-3 ]
  • C5H5Br2N3O [ No CAS ]
  • 2
  • [ 26272-85-5 ]
  • [ 4522-35-4 ]
  • 3-iodo-1-(oxetan-3-yl)-1H-pyrazole [ No CAS ]
YieldReaction ConditionsOperation in experiment
414 mg With sodium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at 45℃; for 76h;Cooling with ice; <strong>[4522-35-4]3-iodo-1H-pyrazole</strong> (503 mg, 2.6 mmol) was added as a solution in DMF (1 mL) to a 1.0 M THF solution of NaHMDS (2.9 mL, 2.9 mmol) that had been pre-cooled in an ice water bath. Additional portions of DMF (2×1 mL) were used to ensure complete transfer. 3-iodooxetane (0.41 mL, 4.7 mmol) was added in one portion and the reaction mixture was allowed to warm to r.t. After 1 h, the reaction mixture was heated to 45 C. and allowed to stir for an additional 75 h. The mixture was cooled and diluted with EtOAc, and water. The aqueous phase was extracted with EtOAc. The combined organic phase was washed with water and were dried over Na2SO4, filtered and concentrated to afford a crude residue that was purified by silica gel chromatography (0-30% EtOAc in hexanes) to provide 3-iodo-1-(oxetan-3-yl)-1H-pyrazole 7.53 (414 mg). Regiochemistry was confirmed as drawn via NOE studies.
 

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