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Chemical Structure| 25487-66-5

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Product Details of 3-Carboxyphenylboronic acid

CAS No. :25487-66-5
Formula : C7H7BO4
M.W : 165.94
SMILES Code : O=C(O)C1=CC=CC(B(O)O)=C1
MDL No. :MFCD00036833
InChI Key :DBVFWZMQJQMJCB-UHFFFAOYSA-N
Pubchem ID :2733957

Safety of 3-Carboxyphenylboronic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 3-Carboxyphenylboronic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 25487-66-5 ]
  • Downstream synthetic route of [ 25487-66-5 ]

[ 25487-66-5 ] Synthesis Path-Upstream   1~2

  • 1
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  • [ 25487-66-5 ]
  • [ 4385-78-8 ]
YieldReaction ConditionsOperation in experiment
83% With potassium carbonate In water; acetonitrileReflux Example 165 A3-(pyridin-4-yl)benzoic acid; To a solution of 3-boronobenzoic acid (1.5 g, 9 mmol) and 4-bromopyridine (1.5 g, 9.9 mmol) in acetonitrile (40 mL) and water (40 mL), potassium carbonate (5.5 g, 40 mmol), Bis(triphenylphosphine)palladium(II) chloride (400 mg, 0.37 mmol) was added. The mixture was stirred under reflux overnight. Then the hot suspension was filtered and concentrated to half of the original volume and washed with dichloromethane. The aquatic phase was adjusted to pH=3 with hydrochloric acid (1 M) and filtrated, washed with water. The residue was dried in vacuum to obtain 1.5 g 3-(pyridin-4-yl)benzoic acid. Yield: 83percent. LC-MS (ESI) m/z: 200 (M+1)+.
References: [1] Patent: US2009/197863, 2009, A1, . Location in patent: Page/Page column 76.
  • 2
  • [ 25487-66-5 ]
  • [ 19524-06-2 ]
  • [ 4385-78-8 ]
References: [1] Inorganic Chemistry, 2016, vol. 55, # 3, p. 1089 - 1095.
 

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