Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 2909-38-8 Chemical Structure| 2909-38-8

Structure of 2909-38-8

Chemical Structure| 2909-38-8

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Product Citations

Canale, Vittorio ; Czekajewska, Joanna ; Klesiewicz, Karolina ; Papiez, Monika ; Kuziak, Agata ; Witek, Karolina , et al.

Abstract: The alarming increase in the resistance of bacteria to the currently available antibiotics necessitates the development of new effective antimicrobial agents that are active against bacterial pathogens causing major public health problems. For this purpose, our inhouse libraries were screened against a wide panel of clin. relevant Gram-pos. and Gram-neg. bacteria, based on which compound I was selected for further optimization. Synthetic efforts in a group of arylurea derivatives of aryloxy(1-phenylpropyl) alicyclic diamines, followed with an in vitro evaluation of the activity against multidrug-resistant strains identified compound 44 (1-(3-chlorophenyl)-3-(1-{3-phenyl-3-[3-(trifluoromethyl)phenoxy] propyl}piperidin-4-yl)urea). Compound 44 showed antibacterial activity against Gram-pos. bacteria including fatal drug-resistant strains i.e., Staphylococcus aureus (methicillin-resistant, MRSA; vancomycin-intermediate, VISA) and Enterococcus faecium (vancomycin-resistant, VREfm) at low concentrations (0.78-3.125 μg/mL) comparable to last resort antibiotics (i.e., vancomycin and linezolid). It is also potent against biofilm-forming S. aureus and Staphylococcus epidermidis (including linezolid-resistant, LRSE) strains, but with no activity against Gram-neg. bacteria (Escherichia coli, Klebsiella pneumoniae and Pseudomonas aeruginosa). Compound 44 showed strong bactericidal properties against susceptible and drug-resistant Gram-pos. bacteria. Depolarization of the bacterial cytoplasmic membrane induced by compound 44 suggests a dissipation of the bacterial membrane potential as its mechanism of antibacterial action. The high antimicrobial activity of compound 44, along with its selectivity over mammalian cells (lung MCR-5 and skin BJ fibroblast cell lines) and no hemolytic properties toward horse erythrocytes, proposes arylurea derivatives of aryloxy(1-phenylpropyl) alicyclic diamines for development of novel antibacterial agents.

Keywords: Arylurea derivatives ; Antibacterial properties ; Anti-MRSA activity ; Anti-VRE activity ; Anti-LRSE activity ; Depolarization of bacterial cell membrane

Alternative Products

Product Details of [ 2909-38-8 ]

CAS No. :2909-38-8
Formula : C7H4ClNO
M.W : 153.57
SMILES Code : O=C=NC1=CC(Cl)=CC=C1
MDL No. :MFCD00002016
InChI Key :HHIRBXHEYVDUAM-UHFFFAOYSA-N
Pubchem ID :17968

Safety of [ 2909-38-8 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314-H330-H334
Precautionary Statements:P260-P280-P284-P305+P351+P338-P310
Class:6.1
UN#:2206
Packing Group:

Application In Synthesis of [ 2909-38-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2909-38-8 ]

[ 2909-38-8 ] Synthesis Path-Downstream   1~8

  • 2
  • [ 7149-18-0 ]
  • [ 2909-38-8 ]
  • 2-[3-(3-Chloro-phenyl)-ureido]-cyclopent-1-enecarboxylic acid ethyl ester [ No CAS ]
  • 3
  • [ 42019-78-3 ]
  • [ 2909-38-8 ]
  • (3-Chloro-phenyl)-carbamic acid 4-(4-chloro-benzoyl)-phenyl ester [ No CAS ]
  • 4
  • [ 117011-70-8 ]
  • [ 2909-38-8 ]
  • [ 121809-75-4 ]
  • 5
  • [ 180995-12-4 ]
  • [ 2909-38-8 ]
  • [ 214360-73-3 ]
  • N-[4-(3-amino-1H-pyrazolo[3,4-b]pyridin-4-yl)phenyl]-N'-(3-chlorophenyl)urea [ No CAS ]
  • N-[4-(3-amino-1H-pyrazolo[4,3-c]pyridin-4-yl)phenyl]-N'-(3-chlorophenyl)urea [ No CAS ]
  • 6
  • [ 604-50-2 ]
  • [ 2909-38-8 ]
  • [ 1629888-34-1 ]
YieldReaction ConditionsOperation in experiment
80% General procedure: A solution of <strong>[604-50-2]1-methylquinazoline-2,4(1H,3H)-dione</strong>2 (0.1 mmol) in dimethylformamide (1 mL) was taken andcooled to 0-5 oC in an ice bath. Triethylamine (0.12 mmol)was added to cold reaction mixture and stirred for 30 min.Different substituted isocyanates (0.1 mmol) were added tothe mixture and allowed to stir at room temperature for 4 h.The progress of the reaction was monitored by TLC. Uponcompletion, the reaction mixture was diluted with water andextracted with ethyl acetate. The organic layer was washedwith water and dried over anhydrous sodium sulfate. Thefiltrate was concentrated in vaccuo to get the crude productwhich was purified by column chromatography over silicagel (60-120 mesh) using hexane: ethyl acetate (9:1) as eluentto afford the thiourea in 80-87% yields.
  • 7
  • [ 777-12-8 ]
  • [ 2909-38-8 ]
  • N-(6-trifluoromethylbenzothiazole-2-yl)-N'-(3-chlorophenyl)urea [ No CAS ]
YieldReaction ConditionsOperation in experiment
10% In tetrahydrofuran; at 110℃; for 3.5h;Microwave irradiation; Example 2: General procedure for synthesis of compounds 24 and 46. (0108) (0109) General methodology: In a microwave vial benzothiazole derivative and the corresponding isocyanate is added in each case. Next, THF is added as solvent. The vial is introduced into the microwave reactor and heated to the temperature for the time indicated in each case. After the reaction time, ethyl acetate (50 mL) and water (50 mL) is added. The organic phase is dried over anhydrous MgS04 and the solvent is removed under reduced pressure. The obtained residue was purified by flash column chromatography using Isolera One equipment, in all cases a mixture of hexane and ethyl acetate as eluent was used. N-(6-trifluoromethylbenzothiazole-2-yl)-N'-(3-chlorophenyl)urea (24): (0110) Reagents: 1-isocianato-3-chlorobenzene (175.8 mg, 1.2 mmol), 2-amino-6-trifluoromethylbenzothiazole (250 mg, 1.2 mmol) and THF (0.4 mL). Reaction conditions: 3 hours and 30 min under microwave irradiation at 110°C. Purification by flash column chromatography using hexane/ethyl acetate (3:1) to obtain a white solid. Yield: 43.2 mg, 10percent. Mp: 222°C-223°C 1H NMR (500 MHz, DMSO-d6) delta: 11.16 (s, 1 H), 9.38 (s, 1 H), 8.41 (s, 1 H), 7.73 (s, 1 H), 7.69 (dd, J = 8.5, 1.9 Hz, 1 H), 7.38 (s, 1 H), 7.35 (t, J = 7.9 Hz, 2H), 7.11 (d, J = 8.5 Hz, 1H). 13C NMR (126 MHz, DMSO-d6) delta: 162.6, 152.0, 140.3, 133.7, 131.0, 125.0 (q, J = 271.7 Hz), 123.6 (d, J = 31.8 Hz), 123.5, 123.4 (d, J = 2.5 Hz), 120.1 (d, J = 4.3 Hz), 118.8, 117.9. HPLC purity: >99percent. MS (ES) m/z: 372 [M+H]+.
  • 8
  • [ 98-32-8 ]
  • [ 2909-38-8 ]
  • 3-(3-(3-chlorophenyl)ureido)-4-hydroxybenzenesulfonamide [ No CAS ]
 

Historical Records

Categories