Home Cart Sign in  
Chemical Structure| 2758-98-7 Chemical Structure| 2758-98-7

Structure of 2758-98-7

Chemical Structure| 2758-98-7

Methyl piperazine-2-carboxylate

CAS No.: 2758-98-7

4.5 *For Research Use Only !

Cat. No.: A701626 Purity: 98+%

Change View

Size Price

US Stock

Global Stock

In Stock
100mg łÇÍÿ¶ÊÊ Inquiry Inquiry
250mg ł§òǶÊÊ Inquiry Inquiry
1g łîÊͶÊÊ Inquiry Inquiry

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • 100mg

    łÇÍÿ¶ÊÊ

  • 250mg

    ł§òǶÊÊ

  • 1g

    łîÊͶÊÊ

In Stock

- +

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 2758-98-7 ]

CAS No. :2758-98-7
Formula : C6H12N2O2
M.W : 144.17
SMILES Code : O=C(C1NCCNC1)OC
MDL No. :MFCD07772085

Safety of [ 2758-98-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 2758-98-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2758-98-7 ]

[ 2758-98-7 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 58632-95-4 ]
  • [ 2758-98-7 ]
  • [ 129799-08-2 ]
  • 2
  • [ 24424-99-5 ]
  • [ 2758-98-7 ]
  • [ 129799-08-2 ]
YieldReaction ConditionsOperation in experiment
99% With triethylamine; In methanol; at 25℃; for 12h; To a solution of methyl piperazine-2-carboxylate (4.30 g, crude) and TEA (8.02 g, 79.2 mmol, 11.0 mL) in MeOH (50.0 mL) was added di-tert-butyl dicarbonate (4.32 g, 19.8 mmol, 4.55 mL). After stirring at 25 C for 12 hours, the reaction mixture was filtered and concentrated under reduced pressure to dryness. The residue was purified by column chromatography (S1O2, DCM / MeOH = 1 :0 to 20: 1) to give l-(tert-butyl) 3-methyl piperazine-l,3-dicarboxylate (4.80 g, 19.7 mmol, two steps, 99.0 % yield) as a colorless oil^H MR (400 MHz, chloroform-d) delta = 4.10 - 3.85 (m, 1H), 3.73 (s, 3H), 3.71 - 3.65 (m, 1H), 3.47 - 3.38 (m, 1H), 3.10 - 2.98 (m, 2H), 2.78 - 2.66 (m, 1H), 2.17 (s, 1H), 1.46 (s, 9H).
4.8 g With triethylamine; In methanol; at 25℃; for 12h; To a solution of methyl piperazine-2-carboxylate (4.30 g, crude) and TEA (8.02 g, 79.2 mmol, 11.0 mL) in MeOH (50.0 mL) was added di-tert-butyl dicarbonate (4.32 g, 19.8 mmol, 4.55 mL). After stirring at 25° C. for 12 hours, the reaction mixture was filtered and concentrated under reduced pressure to dryness. The residue was purified by column chromatography (SiO 2, DCM/MeOH=1:0 to 20:1) to give 1-(tert-butyl) 3-methyl piperazine-1,3-dicarboxylate (4.80 g, 19.7 mmol, two steps, 99.0% yield) as a colorless oil. 1H NMR (400 MHz, chloroform-d) delta=4.10-3.85 (m, 1H), 3.73 (s, 3H), 3.71-3.65 (m, 1H), 3.47-3.38 (m, 1H), 3.10-2.98 (m, 2H), 2.78-2.66 (m, 1H), 2.17 (s, 1H), 1.46 (s, 9H).
4.80 g With methanol; triethylamine; at 25℃; for 12h; To a solution of methyl piperazine-2-carboxylate (4.30 g, crude) and TEA (8.02 g, 79.2 mmol, 1 1.0 mL) in MeOH (50.0 mL) was added di-tert-butyl dicarbonate (4.32 g, 19.8 mmol, 4.55 mL). After stirring at 25 C for 12 hours, the reaction mixture was filtered and concentrated under reduced pressure to dryness. The residue was purified by column chromatography (Si02, DCM / MeOH = 1 :0 to 20: 1) to give 1 -(tert-butyl) 3-methyl piperazine- l ,3-dicarboxylate (4.80 g, 19.7 mmol, two steps, 99.0 % yield) as a colorless oil.'H NMR (400 MHz, chloroform-d) 5 = 4.10 - 3.85 (m, 1H), 3.73 (s, 3H), 3.71 - 3.65 (m, 1H), 3.47 - 3.38 (m, 1 H), 3.10 - 2.98 (m, 211), 2.78 - 2.66 (m, 1H), 2.17 (s, 1H), 1.46 (s, 9H).
 

Historical Records

Technical Information

Categories