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Chemical Structure| 274-80-6 Chemical Structure| 274-80-6

Structure of 274-80-6

Chemical Structure| 274-80-6

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Product Details of [ 274-80-6 ]

CAS No. :274-80-6
Formula : C6H5N3
M.W : 119.12
SMILES Code : C12=NN=CN1C=CC=C2
MDL No. :MFCD09994416
InChI Key :AYSYSOQSKKDJJY-UHFFFAOYSA-N
Pubchem ID :249770

Safety of [ 274-80-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 274-80-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 274-80-6 ]

[ 274-80-6 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 274-80-6 ]
  • [ 4922-68-3 ]
YieldReaction ConditionsOperation in experiment
60% With N-Bromosuccinimide; potassium carbonate; potassium penicillin V; In chloroform; 3-bromo[1,2,4]triazolo[4,3-a]pyridine A mixture of [1,2,4]triazolo[4,3-a]pyridine (1.26 g) and NBS (1.98 g) with chloroform is refluxed for 5 h and then left for 14 h at room temperature. A saturated aqueous solution of potassium carbonate (200 ml) and KOH (20 g) are added, the mixture is shaken and the organic layer is separated. The aqueous layer is extracted with DCM twice. The combined organic extract is dried over Na2SO4 and the solvent is evaporated in vacuum giving the desired product with 60% yield.
  • 2
  • [ 274-80-6 ]
  • [ 5460-32-2 ]
  • 3-(3,4-dimethoxyphenyl)-[1,2,4]triazolo[4,3-a]pyridine [ No CAS ]
  • 3
  • [ 274-80-6 ]
  • [ 1214337-05-9 ]
  • 6-([1,2,4]triazolo[4,3-a]pyridin-3-yl)-5-fluoropicolinate [ No CAS ]
YieldReaction ConditionsOperation in experiment
12.2% With bis-triphenylphosphine-palladium(II) chloride; caesium carbonate; In 1,4-dioxane; at 120.0℃; for 3.0h; Methyl 6-chloro-5-fluoropicolinate (3.2 g, 16.7 mmol),[1,2,4] triazolo [4,3-a] pyridine (1.8 g, 15.1 mmol) was dissolved in 1,4-dioxane (40 mL), and dichloroditriphenylphosphine palladium ( 1.06g, 1.5mmol), cesium carbonate (9.6g, 29.5mmol), microwave heating to 120 C, 3 hours, filtration, concentration, column chromatography (petroleum ether: ethyl acetate = 3: 1) to obtain the compound (500mg, Yield: 12.2%).
 

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[ 274-80-6 ]

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