5460-32-2|4-Iodo-1,2-dimethoxybenzene| Ambeed

CAS No. :	5460-32-2
Formula :	C₈H₉IO₂
M.W :	264.06
SMILES Code :	COC1=CC(I)=CC=C1OC
MDL No. :	MFCD00094416
InChI Key :	PUCISUQLWLKKJH-UHFFFAOYSA-N
Pubchem ID :	230307

Safety of [ 5460-32-2 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H332-H335
Precautionary Statements:	P261-P280-P305+P351+P338

Calculated chemistry of [ 5460-32-2 ] Show Less

Physicochemical Properties

Num. heavy atoms	11
Num. arom. heavy atoms	6
Fraction Csp3	0.25
Num. rotatable bonds	2
Num. H-bond acceptors	2.0
Num. H-bond donors	0.0
Molar Refractivity	52.14
TPSA ? Topological Polar Surface Area: Calculated from Ertl P. et al. 2000 J. Med. Chem.	18.46 Å²

Lipophilicity

Log P_o/w (iLOGP)? iLOGP: in-house physics-based method implemented from Daina A et al. 2014 J. Chem. Inf. Model.	2.43
Log P_o/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by XLOGP program, version 3.2.2, courtesy of CCBG, Shanghai Institute of Organic Chemistry	2.1
Log P_o/w (WLOGP)? WLOGP: Atomistic method implemented from Wildman SA and Crippen GM. 1999 J. Chem. Inf. Model.	2.31
Log P_o/w (MLOGP)? MLOGP: Topological method implemented from Moriguchi I. et al. 1992 Chem. Pharm. Bull. Moriguchi I. et al. 1994 Chem. Pharm. Bull. Lipinski PA. et al. 2001 Adv. Drug. Deliv. Rev.	2.37
Log P_o/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	2.78
Consensus Log P_o/w? Consensus Log P_o/w: Average of all five predictions	2.4

Water Solubility

Log S (ESOL):? ESOL: Topological method implemented from Delaney JS. 2004 J. Chem. Inf. Model.	-3.07
Solubility	0.224 mg/ml ; 0.000848 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble
Log S (Ali)? Ali: Topological method implemented from Ali J. et al. 2012 J. Chem. Inf. Model.	-2.12
Solubility	2.01 mg/ml ; 0.00762 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by FILTER-IT program, version 1.0.2, courtesy of SILICOS-IT, http://www.silicos-it.com	-3.6
Solubility	0.0656 mg/ml ; 0.000248 mol/l
Class? Solubility class: Log S scale Insoluble < -10 < Poorly < -6 < Moderately < -4 < Soluble < -2 Very < 0 < Highly	Soluble

Pharmacokinetics

GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg	High
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg	Yes
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) and tested on 415 molecules (test set) 10-fold CV: ACC=0.72 / AUC=0.77 External: ACC=0.88 / AUC=0.94	No
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.83 / AUC=0.90 External: ACC=0.84 / AUC=0.91	Yes
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) and tested on 3000 molecules (test set) 10-fold CV: ACC=0.80 / AUC=0.86 External: ACC=0.80 / AUC=0.87	No
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) and tested on 2075 molecules (test set) 10-fold CV: ACC=0.78 / AUC=0.85 External: ACC=0.71 / AUC=0.81	No
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) and tested on 1068 molecules (test set) 10-fold CV: ACC=0.79 / AUC=0.85 External: ACC=0.81 / AUC=0.87	No
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) and tested on 2579 molecules (test set) 10-fold CV: ACC=0.77 / AUC=0.85 External: ACC=0.78 / AUC=0.86	No
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from Potts RO and Guy RH. 1992 Pharm. Res.	-6.42 cm/s

Druglikeness

Lipinski? Lipinski (Pfizer) filter: implemented from Lipinski CA. et al. 2001 Adv. Drug Deliv. Rev. MW ≤ 500 MLOGP ≤ 4.15 N or O ≤ 10 NH or OH ≤ 5	0.0
Ghose? Ghose filter: implemented from Ghose AK. et al. 1999 J. Comb. Chem. 160 ≤ MW ≤ 480 -0.4 ≤ WLOGP ≤ 5.6 40 ≤ MR ≤ 130 20 ≤ atoms ≤ 70	None
Veber? Veber (GSK) filter: implemented from Veber DF. et al. 2002 J. Med. Chem. Rotatable bonds ≤ 10 TPSA ≤ 140	0.0
Egan? Egan (Pharmacia) filter: implemented from Egan WJ. et al. 2000 J. Med. Chem. WLOGP ≤ 5.88 TPSA ≤ 131.6	0.0
Muegge? Muegge (Bayer) filter: implemented from Muegge I. et al. 2001 J. Med. Chem. 200 ≤ MW ≤ 600 -2 ≤ XLOGP ≤ 5 TPSA ≤ 150 Num. rings ≤ 7 Num. carbon > 4 Num. heteroatoms > 1 Num. rotatable bonds ≤ 15 H-bond acc. ≤ 10 H-bond don. ≤ 5	0.0
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat implemented from Martin YC. 2005 J. Med. Chem.	0.55

Medicinal Chemistry

PAINS? Pan Assay Interference Structures: implemented from Baell JB. & Holloway GA. 2010 J. Med. Chem.	0.0 alert
Brenk? Structural Alert: implemented from Brenk R. et al. 2008 ChemMedChem	1.0 alert: heavy_metal
Leadlikeness? Leadlikeness: implemented from Teague SJ. 1999 Angew. Chem. Int. Ed. 250 ≤ MW ≤ 350 XLOGP ≤ 3.5 Num. rotatable bonds ≤ 7	No; 1 violation:MW<0.0
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) based on 1024 fragmental contributions (FP2) modulated by size and complexity penaties, trained on 12'782'590 molecules and tested on 40 external molecules (r² = 0.94)	2.38

Application In Synthesis of [ 5460-32-2 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Upstream synthesis route of [ 5460-32-2 ]
Downstream synthetic route of [ 5460-32-2 ]

[ 5460-32-2 ] Synthesis Path-Upstream 1~1

1
[ 5460-32-2 ]
[ 808-57-1 ]

References: [1] Journal of the American Chemical Society, 1980, vol. 102, # 21, p. 6504 - 6512.

Yield	Reaction Conditions	Operation in experiment
95%	With N-iodo-succinimide; trifluoroacetic acid; In acetonitrile; at 80℃; for 2h;	To a stirred solution of 1,2-dimethoxybenzene 7 (1mL, 7.85mmol) in acetonitrile (5mL) was added N-iodosuccinimide (NIS) (1.94g, 8.63mmol) and trifluoroacetic acid (TFA) (0.18mL, 2.35mmol). The mixture was stirred for 2hat 80C. After that period the resulting mixture was poured into ice (20g) and water (100mL) and a saturated solution of sodium thiosulfate was added. The aqueous layer was extracted with dichloromethane (3×100mL), dried over anhydrous sodium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography using dichloromethane as eluent to give the desired 4-iodo-1,2-dimethoxybenzene 8 in excellent yield (1.97g, 95%). This compound showed spectroscopic and analytical data identical to one previously reported [37].
85%	With 3-iodo-4,4-dimethyloxazolidin-2-one; In acetonitrile; for 15h;Reflux;	[00274] A mixture of veratrole (0.22 g, 1.63 mmol), 3-iodo-4,4- dimethyloxazolidin-2-one (0.6 g, 2.44 mmol) and MeCN (10 mL) was stirred under reflux conditions for 15 h and concentrated in vacuo. The residue was treated with 1 M aq Na2S03 (5 mL), extracted with hexane (3 x 10 mL) and then with DCM (3 x 10 mL). The combined DCM extracts were dried over Na2S04, filtered and concentrated in vacuo to give 0.27 g (95%) of 4,4-dimethyl-2- oxazolidinone. The combined hexane extracts were washed with 1 M aq Na2S03 (10 mL), dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by chromatography on silica gel (eluent hexane/DCM 100:0 to 0:100 v/v) to give 0.36 g (85%) of 4-iodo- 1,2-dimethoxybenzene. 1H NMR: δ 7.19 (dd, J = 1.5 Hz, J = 8.5 Hz, 1H), 7.09 (d, J = 1.5 Hz, 1H), 6.59 (d, J = 8.5 Hz, 1H), 3.83 (s, 3H), 3.82 (s, 3H) ppm; 13C NMR: δ 149..8, 149.1, 129.7, 120.3, 113.2, 82.3, 56.1, 55.9 ppm.
68%	With N-iodosaccharine; at 20℃;Ionic liquid; Darkness;	General procedure: To a solution of 54 mg (0.5 mmol) of anisole in 1 mL of BMIM BF4 was added 158 mg (0.51 mmol) of N-iodosaccharin. The reaction was stirred at room temperature protected from light for 8-12 h. The product was then isolated by extraction with ether (3 × 3 mL), followed by evaporation of the solvent to afford the desired iodinated product. In some cases, the product was contaminated with small amounts of BMIM BF4. This could be removed via filtration with ether through a short plug of silica. Alternatively, it could be avoided entirely by extraction of the product from the reaction using 1:1 ether/hexanes in place of pure ether. The identity of all products were confirmed by comparison (spectral and mp) with either commercially available samples or data reported in the literature as indicated in Table 1.

Yield	Reaction Conditions	Operation in experiment
80%	With triethylamine;bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; In tetrahydrofuran; at 20℃; for 4h;	3-[4-(3,4-Dimethoxyphenyl)-but-3-ynyl]-1,3-oxazolidin-2-one (34). Triethylamine (0.08 mL, 0.574 mmol) and Pd(PPh3)Cl2 (8.0 mg, 0.011 mmol) were added to a mixture of 3,4-dimethoxyphenyl iodide (33) (64 mg, 0.242 mmol) and alkyne 25 (34 mg, 0.245 mmol) in THF (3 mL) at room temperature. Then Cu(I)I (5 mg, 0.026 mmol) was added. The resulting mixture was stirred at room temperature for 4 h. The reaction was quenched with water (10 mL) and concentrated to remove the organic solvents. The residue was diluted with ethyl acetate (15 mL). The organic layer was separated and washed with brine (2×10 mL), dried over sodium sulfate and concentrated. The residue was purified by column chromatography on silica gel (25 g), eluting with EtOAc-hexanes (10-50%) to afford the product 34 (54 mg) as solid in 80% yield: mp 78-79 C. 1H NMR (300 MHz, CDCl3) δ 6.95 (dd, J=2.1 Hz, J=8.4 Hz, 1H), 6.88 (d, J=1.8 Hz, 1H), 6.76 (d, J=8.4 Hz, 1H), 4.32 (t, J=7.8 Hz, 2H), 3.86 (s, 3H), 3.85 (s, 3H), 3.73 (t, J=7.8 Hz, 2H), 3.51 (t, J=6.6 Hz, 2H), 2.67 (t, J=6.6 Hz, 2H); ESIMS m/z (rel intensity) 276.05 (MH+, 94), 298.05 (MNa+, 98). Anal. (C15H17NO4) C, H, N.

Yield	Reaction Conditions	Operation in experiment
95%	With bromine; sodium hydrogensulfite; In P2 O5; acetic acid;	4-Iodoveratrole (26.0 g, 0.0985M) in acetic acid (25 ml) was treated with bromine (6.5 ml, 0.127M) in acetic acid (30 ml) and stirred at room temperature for one hour. The mixture was diluted with water (300 ml) and treated with sodium bisulfite to discharge the excess bromine. The white solid was filtered, washed with water and dried in vacuo over P2 O5 to give 4-bromo-5-iodoveratrole (33.0 g, 95% yield) as a white solid, mp 98-100 C. (literature: Baker et al., J. Chem. Soc. 3986 (1961), mp 102-104 C.). NMR (CDCl3) δ 3.83 ppm (s, 6H, (2x) OCH3), 7.06 (s, 1H, ArH), 7.21 (s, 1H, ArH).

Yield	Reaction Conditions	Operation in experiment
31%	With copper(l) iodide; (R,R)-N,N'-dimethyl-1,2-diaminocyclohexane; potassium carbonate; In toluene; for 16h;Inert atmosphere; Reflux;	Intermediate A19: 3-ferf-Butyl-1 -(3,4-dimethoxyphenyl)-1W-pyrazol-5-amine.Intermediate A19To a solution of 4-iodo-1 ,2-dimethoxybenzene (1 .10 g, 4.17 mmol) in anhydrous toluene (5.0 mL) was added 3-ierf-butyl-1 - -pyrazol-5-amine (638 mg, 4.58 mmol) followed by (1 R,2f?)- /V1,A 2-dimethylcyclohexane-1 ,2-diamine (130 μ, 0.83 mmol) and potassium carbonate (1.15 g, 8.3 mmol). The mixture was purged with N2, copper(l) iodide (40 mg, 0.21 mmol) was added and the reaction mixture was heated at reflux under N2 for 16 hr. The resulting mixture was cooled to RT and was partitioned between EtOAc (100 mL) and water (150 mL). The organic layer was separated and was washed with aq. citric acid solution (10% w/v, 50 mL) followed by brine (50 mL) and then dried and evaporated in vacuo. The residue was purified by flash column chromatography (S1O2, 80 g, EtOAc in isohexane, 0-70%, gradient elution). The impure product so obtained was dissolved in ether (1.0 mL), isohexane (10 mL) was added and the resulting precipitate was collected by filtration to afford the title compound, Intermediate A19, as a purple solid (364 mg, 31 %); R' 3.55 min (Method 1 ); m/z 276 (M+H)+ (ES+). Intermediate 20: 3-ferf-Butyl-1 -(4-methylthiophen-2-yl)-1W-pyrazol-5-amine.

Yield	Reaction Conditions	Operation in experiment
31.6%	With bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; triethylamine; In acetonitrile; at 80℃; for 3h;Inert atmosphere; Sealed tube;	General procedure: To a mixture of Pd(PPh3)2Cl2(0.086 g, 0.12 mmol), CuI (0.047 g, 0.24 mmol), and Et3N (0.51 mL, 3.66 mmol) in MeCN (20 mL) were added substituted phenylacetylene (2.44 mmol) and substituted iodobenzene (2.21 mmol). The reaction mixture was recharged with argon and stirred at 80C for 3 h in a sealed tube. The mixture was extracted with ethyl acetate. The organic layer was washed with saturated aqueous NaCl and concentrated in vacuo. The residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate, 10:1) to afford pure product.

Yield	Reaction Conditions	Operation in experiment
51%	With copper(l) iodide; sodium carbonate; triphenylphosphine; In N,N-dimethyl-formamide; at 160℃; for 3h;	A suspension of 0.212 g of Na2C03 (2 mmol), 0.262 g of PPh3 (1 mmol), 0.206 g (1 mmol) of 31 and 0.316 g of 4-iodoveratrole (1.2 mmol) was formed in 1 mL of DMF. Then, 0.190 g (1 mmol) of Cul was added. The mixture was stirred at 160 C for 3 h and quenched by pouring into 50 mL of water containing 5% NH4+OH~. The product was extracted with 50 mL DCM, the organic layer dried and concentrated, and the crude product purified by PTLC to give 0.174 g (51% yield) of 32 as a yellow solid. 1H NMR (200 MHz, CDC13) δ 7.60 (d, / = 8.4 Hz, 1H), 7.54, (bs, 1H), 7.24 (s, 1H), 7.19 (bs, 1H), 7.10 (s, 1H), 6.90-6.83 (m, 2H), 3.91-3.86 (4 overlapping multiplets, 12H). 13C NMR (50 MHz, CDC13) δ 160.7, 150.9, 149.3, 149.2, 132.1, 132.0, 122.0, 121.2, 120.4, 119.3, 117.1, 111.5, 111.1, 109.1, 107.5, 56.01, 55.92

Historical Records

Technical Information

Related Functional Groups of
[ 5460-32-2 ]

Aryls

A262292 [766-85-8]

3-iodoanisole

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A155143 [25245-29-8]

5-Iodo-1,2,3-trimethoxybenzene

Similarity: 0.88

A139160 [41046-70-2]

2-Iodo-5-methoxyphenol

Similarity: 0.85

A420370 [2974-94-9]

1-Iodo-4-phenoxybenzene

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A174393 [111726-46-6]

2-Iodo-6-methoxyphenol

Similarity: 0.81

Ethers

A262292 [766-85-8]

3-iodoanisole

Similarity: 0.94

A155143 [25245-29-8]

5-Iodo-1,2,3-trimethoxybenzene

Similarity: 0.88

A139160 [41046-70-2]

2-Iodo-5-methoxyphenol

Similarity: 0.85

A420370 [2974-94-9]

1-Iodo-4-phenoxybenzene

Similarity: 0.85

A174393 [111726-46-6]

2-Iodo-6-methoxyphenol

Similarity: 0.81

61%	With 1-iodo-3,5,5-trimethylhydantoin; In acetonitrile; at 20℃; for 48h;	[00276] A mixture of veratrole (0.22 g, 1.63 mmol), l-iodo-3,5,5- trimethylhydantoin (0.53 g, 1.97 mmol) and MeCN (10 mL) was stirred for 48 h at rt and concentrated in vacuo. The residue was treated with 1 M aq Na2S03 (5 mL), extracted with hexane (3 x 10 mL) and then with DCM (3 x 10 mL). The combined DCM extracts were dried over Na2S04, filtered and concentrated in vacuo to give 0.25 g (90%) of 3,5,5-trimethylhydantoin (3,5,5-TMH). The combined hexane extracts were washed with 1 M aq Na2S03 (10 mL), dried over Na2S04, filtered and concentrated in vacuo. The residue was purified by chromatography on silica gel (eluent hexane/DCM 100:0 to 0: 100 v/v) to give 0.31 g (61%) of 4-iodo-l,2-dimethoxybenzene.
	With N-iodo-succinimide; trifluoroacetic acid; In acetonitrile;Reflux;	General procedure: To a solution of the appropriate benzene derivative 6a,b (1.0 mmol) in acetonitrile (20 mL) were added NIS (0.247 g, 1.1 mmol) and a catalytic amount of TFA (0.023 mL, 0.3 mmol). The reaction mixture was stirred at reflux overnight. After this time, it was poured onto ice (50 g) and H2O (100 mL) and then, it was treated with a saturated solution of Na2S2O3. The obtained precipitate was filtered off, taken in CH2Cl2 and dried over anhydrous Na2SO4. The solvent was evaporated to dryness and the obtained residue was purified by silica gel column chromatography using CH2Cl2/C6H14 (1:1) as eluent.

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Physical hazards
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H200	Unstable explosive
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H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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Product Details of [ 5460-32-2 ]

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Calculated chemistry of [ 5460-32-2 ] Show Less

Physicochemical Properties

Lipophilicity

Water Solubility

Pharmacokinetics

Druglikeness

Medicinal Chemistry

Application In Synthesis of [ 5460-32-2 ]

[ 5460-32-2 ] Synthesis Path-Upstream 1~1

[ 5460-32-2 ] Synthesis Path-Downstream 1~29

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Technical Information

Categories

Related Functional Groups of
[ 5460-32-2 ]

Aryls

Ethers

Precautionary Statements-General

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Alternative Products

Product Details of [ 5460-32-2 ]

Safety of [ 5460-32-2 ]

Calculated chemistry of [ 5460-32-2 ] Show Less

Physicochemical Properties

Lipophilicity

Water Solubility

Pharmacokinetics

Druglikeness

Medicinal Chemistry

Application In Synthesis of [ 5460-32-2 ]

[ 5460-32-2 ] Synthesis Path-Upstream 1~1

[ 5460-32-2 ] Synthesis Path-Downstream 1~29

Related Products

Historical Records

Technical Information

Categories

Related Functional Groups of [ 5460-32-2 ]

Aryls

Ethers

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

Related Functional Groups of
[ 5460-32-2 ]