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Chemical Structure| 241798-62-9 Chemical Structure| 241798-62-9

Structure of 241798-62-9

Chemical Structure| 241798-62-9

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Griffin, Matthew E. ; Tsukidate, Taku ; Hang, Howard C. ;

Abstract: The characterization of microbiota mechanisms in health and disease has reinvigorated pattern recognition receptors as prominent targets for immunotherapy. Notably, our recent studies on Enterococcus species revealed peptidoglycan remodeling and activation of NOD2 as key mechanisms for microbiota enhancement of immune checkpoint inhibitor therapy. Inspired by this work and other studies of NOD2 activation, we performed in silico ligand screening and developed N-arylpyrazole dipeptides as novel NOD2 agonists. Importantly, our N-arylpyrazole NOD2 agonist is enantiomer-specific and effective at promoting immune checkpoint inhibitor therapy and requires NOD2 for activity in vivo. Given the significant functions of NOD2 in innate and adaptive immunity, these next-generation agonists afford new therapeutic leads and adjuvants for a variety of NOD2-responsive diseases.

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Product Details of [ 241798-62-9 ]

CAS No. :241798-62-9
Formula : C10H9N3O2
M.W : 203.20
SMILES Code : O=C(C1=C(C)N(C2=CC=NC=C2)N=C1)O
MDL No. :MFCD09702991

Safety of [ 241798-62-9 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501
 

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