Home Cart Sign in  
HazMat Fee +

There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Chemical Structure| 2284-20-0 Chemical Structure| 2284-20-0

Structure of 4-Methoxyphenyl isothiocyanate
CAS No.: 2284-20-0

Chemical Structure| 2284-20-0

*Storage: {[sel_prStorage]}

*Shipping: {[sel_prShipping]}

,{[proInfo.pro_purity]}

4.5 *For Research Use Only !

{[proInfo.pro_purity]}
Cat. No.: {[proInfo.prAm]} Purity: {[proInfo.pro_purity]}

Change View

Size Price VIP Price

US Stock

Global Stock

In Stock
{[ item.pr_size ]} Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

  • {[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

  • 1-2 Day Shipping
  • High Quality
  • Technical Support
Product Citations

Alternative Products

Product Details of [ 2284-20-0 ]

CAS No. :2284-20-0
Formula : C8H7NOS
M.W : 165.21
SMILES Code : COC1=CC=C(N=C=S)C=C1
MDL No. :MFCD00011676
InChI Key :VRPQCVLBOZOYCG-UHFFFAOYSA-N
Pubchem ID :75293

Safety of [ 2284-20-0 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314-H317-H334
Precautionary Statements:P260-P261-P264-P272-P280-P285-P301+P330+P331-P302+P352-P303+P361+P353-P304+P340-P304+P341-P305+P351+P338-P310-P321-P333+P313-P342+P311-P363-P405-P501
Class:8
UN#:1760
Packing Group:

Application In Synthesis of [ 2284-20-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2284-20-0 ]

[ 2284-20-0 ] Synthesis Path-Downstream   1~11

  • 1
  • [ 2284-20-0 ]
  • [ 2293-07-4 ]
YieldReaction ConditionsOperation in experiment
100% With ammonium hydroxide; In water; acetonitrile; at 20℃; for 3h; General procedure: To a solution of a (substituted)-phenylisothiocyanate derivative (0.6 M) in MeCN was added aqueous ammonia (25%, 1.5 eq). The solution was stirred at room temperature for 3 h. The reaction mixture was then concentrated. Purification was done by precipitation from a mixture of n-hexane/ethyl acetate mixture (3/2). The pure product was recovered as a powder after filtration in a quantitative yield.
With ammonia; In N,N-dimethyl-formamide; at 20℃; for 1h; To a stirred solution of DMF (4-5 ml), 4-Methoxy aniline (2 mmol, 254 mg) was added in slowly and followed by carbon disulphide (20 mmol (10 eq), 1520 mg) and sodium bicarbonate (2 mmol (1 eq), 168 mg) were added at room temperature. The whole reaction mixture stirred for one hour (until get the yellow color solid) at room temperature. Thiocarbomate formation was monitored by TLC. To this, CoSO4xH2O (25 mol%, 121 mg) and sodium bicarbonate (2 mmol (1 eq), 168 mg) were added slowly for 5 min and the reaction mixture stirred for 1 h. During this period, a block color precipitate was observed and settles at bottom of round bottom flask. The progress of the reaction was investigated by TLC (5% ethylacetate in hexane). After 1 h, ammonia solution (2 ml) was added slowly. Then the whole reaction mixture stirred for 1 h at room temperature. After finish the reaction, the reaction mixture was transferred into centrifuged tubes and the mixture was centrifuged for 10 min by using centrifugation machine. Block color solid was settled in the bottom of centrifuged tubes. The clear solution was concentrated by using rotary evaporator and the crude mixture was purified by silica gel (60-120 mesh) column chromatography using 20% Ethylacetate in Hexane as eluent to afford a 4-Methoxy phenyl thiourea as white solid.
With ammonium hydroxide; In water; ethyl acetate; at 20℃; for 0.166667h; General procedure: To a stirred and ice cooled suspension of dithiocarbamate(Table 2, compound 1) (540 mg, 2 mmol) in ethylacetate (5 mL), was added NaHCO3 (336 mg, 4 mmol). To this was then added TPATB (0.852 g, 2 mmol) pinch wise over a period of 10-15 minutes to yield phenylisothiocyanate. During this period precipitation of elemental sulfur was observed. After complete addition of TPATB, 25% aqueous NH3 (2.5 mL) was added drop wise to the stirred reaction mixture to give 1-phenylthiourea. After stirring for 10 minutes at room temperature, the excess of NH3 was removed in a rotary evaporator whereby the solvent ethylacetate was also simultaneously removed leaving behind the aqueous layer. To the crude reaction mixture was then further added ethyl acetate (5 mL) and NaHCO3 (336 mg,4 mmol). To the resultant solution, TPATB (0.852 g, 2mmol) was added in small pinches, during which further precipitation of elemental sulfur was observed. The conversion of 1-phenylthiourea to phenylcyanamide (Table 2,compound 1b) was observed within 5 minutes of the complete addition of TPATB. Completion of the reaction was confirmed by TLC. The precipitated sulfur was filtered,washed with ethyl acetate (2 × 5 mL). The organic layer was washed with water (2 × 5 mL) and dried over anhydrous Na2SO4, concentrated under reduced pressure and purified over a short column of silica gel eluting it with hexane-ethyl acetate (97:3) to give the pure product (Table2, compound 1b) (188 mg, 80%) as an oily liquid.
With ammonium hydroxide; In N,N-dimethyl-formamide; at 20℃; for 1h; General procedure: Aryl/alkyl isothiocyanate 1a-h,l-n (2 mmol) was addedslowly to stirred DMF (4-5 ml), followed by addition ofaqueous NH3 (2 ml, 2 mmol) at room temperature. Thereaction mixture was stirred for 1 h at room temperature.Thiourea formation was monitored by TLC on silica gel.Then CoSO4·H2O (121 mg, 0.5 mmol, 25 mol %) wasadded slowly followed by addition of NaOAc (164 mg,2 mmol), and the reaction mixture was stirred for 2 h atroom temperature. During this time, black precipitate(CoS) appeared and was removed by centrifugation. Theclear solution was concentrated using rotary evaporator,and the crude mixture was purified by columnchromatography using 10% EtOAc in hexane as eluent toobtain a corresponding cyanamide as a target product.
With ammonium hydroxide; at 0℃; General procedure: Phenyl isothiocyanate 1a-k (3.7mmol) stirred for 30min with aqueous ammonia solution (25%, 5mL) at ice-cold temperature (~0C). The reaction was monitored by TLC and after complete consumption of the starting material, excess of ammonia was shelved under reduced pressure. The remained mixture was co-distilled with toluene (3×15mL), subsequently, the resultant phenylthiourea 2a-k was dried under high vacuum. After complete drying, phenyl thiourea was dissolved in anhydrous DMF (0.33M), and NaN3 (11.11mmol) and CAN (10mol%) were added sequentially portion-wise, followed by dropwise addition of triethylamine (11.11mmol) over a period of 15min. Afterwardthe completion of addition of triethylamine, thereafter reaction mixture was allowed to stir for 4-5h at 100C. Transformation progression of the in situ generated 1-phenylthiourea 2a-k to 1-phenyl-1H-tetrazol-5-ylamine was monitored by using TLC. The product was extracted with ethyl acetate (3×20mL). These assorted organic layers were washed with water (3×20mL) and brine solution (3×20mL) and followed by Na2SO4 to get dried over before concentration under reduced pressure. Finally yielded crude product was purified over a column of silica gel (230-400 mesh) that was saturated with 1% triethylamine and eluted using 8:1:1 chloroform/methanol/methanolic ammonia solvent mixture to obtain tetrazoles 3a-k and 4a-4k in good to excellent yields. Finally structure of the desired finished products was confirmed by their MP, IR, and 1H and 13C NMR spectra.
With ammonium hydroxide; In dimethyl sulfoxide; at 20℃; for 3h; General procedure: To a stirred solution of DMSO (4-5 mL), respectiveisothiocyanate (2 mmol) was added slowly at roomtemperature and stirring further continued for 3 h atroom temperature. The progress of the reaction wasinvestigated by TLC (20% ethylacetate in hexane).After forming the respective substituted thiourea (asper TLC) Fe2(SO4)3.H2O (50 mol %, 417 mg) andNaOAc (2 mmol, 164 mg) were added to that solutionat room temperature, then the reaction mixture wasstirred for 2 h. During this time black color precipitate(FeS) was observed. And it was removed by centrifugation. The clear solution was concentrated byusing a rotary evaporator and the crude mixture waspurified by silica gel (60-120 mesh) column chromatographyusing Ethylacetate in Hexane as eluent toobtain a phenyl cyanamide as a white solid.

  • 2
  • [ 14779-17-0 ]
  • [ 2284-20-0 ]
  • [ 1819-83-6 ]
  • 4
  • [ 2284-20-0 ]
  • [ 379228-26-9 ]
  • [ 628686-91-9 ]
  • 5
  • [ 69583-00-2 ]
  • [ 2284-20-0 ]
  • 4-(4-methoxyphenyl)-1-(pyridin-4-ylacetyl)-thiosemicarbazide [ No CAS ]
  • 6
  • [ 2284-20-0 ]
  • [ 379228-26-9 ]
  • [ 628686-91-9 ]
YieldReaction ConditionsOperation in experiment
49% In toluene; EXAMPLE 21 2-mercapto-5,7-dimethoxy-3-(4-methoxyphenyl)-4(3H)-quinazolinone The Example 3 compound (0.675 g, 3.19 mmol) was refluxed in 20 ml of toluene with 0.525 g (3.2 mmol) of 4-methoxyphenylisothiocyanate for 15 h. The solvent was evaporated and the residue triturated with MeOH/CH2Cl2 to yield 0.537 g of 2-mercapto-5,7-dimethoxy-3-(4-methoxyphenyl)-4(3H)-quinazolinone (49%) as an off-white solid. C17H16N2O4S=344.39 g/mol; HPLC purity=91.7%; ESI-LC/MS (M+H)+=345.2; MP: 322-326 C.; 1H NMR (CDCl3): delta3.85 (3H, s), 3.9 (3H, s), 3.91 (3H, s), 6.06 (1H, d, J=2.1 Hz), 6.08 (1H, d, J=2.1 Hz), 7.02 (1H, d, J=8.6 Hz), 7.16 (2H, d, J=8.6 Hz), 9.38 (1H, s).
  • 7
  • [ 120-35-4 ]
  • [ 2284-20-0 ]
  • 4-Methoxy-3-[3-(4-methoxy-phenyl)-thioureido]-N-phenyl-benzamide [ No CAS ]
YieldReaction ConditionsOperation in experiment
In methane; dichloromethane; Example 83 4-Methoxy-3-[3-(4-methoxy-phenyl)-thioureido]-N-phenyl-benzamide Prepared according to the procedure described for Example 60 using 3-amino-4-methoxy-N-phenyl-benzamide (0.972 g, 4.00 mmol) and 4-methoxyphenyl isothiocyanate (0.77 g, 5.16 mmol), except that after collection of the product obtained upon trituration with hexanes/ethyl acetate, an impurity was present. The impurity was removed by slurrying the solid in dichloromethane/methane 95:5 followed by filtration to afford the product (0.505 g); m.p. 168-169 C. Calculated for C22H21N3O3S: C, 64.85; H, 5.19; N, 10.31. Found: C, 64.55; H, 5.17; N, 10.18.
  • 8
  • [ 5344-27-4 ]
  • [ 2284-20-0 ]
  • [ 1033591-08-0 ]
  • 9
  • [ 69583-00-2 ]
  • [ 2284-20-0 ]
  • 4-(4-methoxyphenyl)-3-(pyridine-4-ylmethyl)-1,2,4-triazoline-5-thione [ No CAS ]
  • 10
  • [ 6265-73-2 ]
  • [ 2284-20-0 ]
  • C16H17N3O3S [ No CAS ]
YieldReaction ConditionsOperation in experiment
74% With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 0℃; for 0.333333h;Inert atmosphere; General procedure: A4 (100mg, 0.6mmol) was combined with 2-chloro-4-nitrophenyl isothiocyanate (129mg, 0.6mmol) in anhydrous THF (30mL) at 0C, followed by the addition of DBU (106mg, 0.7mmol). The resultant mixture was stirred at 0C for 20min, after which the ice bath was removed, and the reaction mixture was stirred at room temperature until the completion of the reaction indicated by TLC. The crude product was purified by column chromatography (chloroform/methanol, 30/1).
  • 11
  • [ 2293-07-4 ]
  • [ 2284-20-0 ]
YieldReaction ConditionsOperation in experiment
In chlorobenzene; for 8h;Reflux; General procedure: The aryl-thioureas (7 mmol) was submitted under 8 h of reflux in chlorobenzene as solvent. The solution was then distilled under reduced pressure for chlorobenzene removal.The aryl-isothiocyanates (3a-d) were used immediately in the subsequent step as crude products [49].
 

Historical Records

Technical Information

Categories