22312-62-5|2-Amino-N-(m-tolyl)benzamide| Ambeed

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Quality Control of [ 22312-62-5 ] Purity: 97% SDS Specification

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Product Details of [ 22312-62-5 ]

CAS No. :	22312-62-5
Formula :	C₁₄H₁₄N₂O
M.W :	226.27
SMILES Code :	O=C(NC1=CC=CC(C)=C1)C2=CC=CC=C2N
MDL No. :	MFCD00442835
InChI Key :	ZLUXETNDOIBMSR-UHFFFAOYSA-N
Pubchem ID :	2467368

Safety of [ 22312-62-5 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H315-H319
Precautionary Statements:	P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313

Application In Synthesis of [ 22312-62-5 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 22312-62-5 ]

[ 22312-62-5 ] Synthesis Path-Downstream 1~35

1
[ 118-48-9 ]
[ 108-44-1 ]
[ 22312-62-5 ]

Yield	Reaction Conditions	Operation in experiment
	In toluene; at 100℃; for 12h;	General procedure: 7.1.13. Solution-phase synthesis of library compounds 21Isatoic anhydride (20) (0.1 mmol) was partitioned into reaction vials and treated with aniline (0.10 mmol) in toluene (1.0 mL) at 100 C for 12 h. The mixture in each vessel was allowed to coolto ambient temperature, and the solvent was removed under reduced pressure. The residue in each vessel was dissolved in pyridine(1.0 mL) and treated with compound 37 (0.10 mol) at ambient temperature for 12 h. The mixture was then treated with polymer-bound tris(2-aminoethyl)amine for 12 h and filtered off. The filtrate was collected in vials and the solutions were evaporatedin vacuo to afford anthranilamide derivatives 21, which were analyzed by HPLC and MS. 21a; FAB-MS m/z 443 [M+H]+, 21b; FABMS m/z 443 [M+H]+, 21c; FAB-MS m/z 443 [M+H]+, 21d; FAB-MS m/z 463 [M+H]+, 21e; FAB-MS m/z 463 [M+H]+, 21g; FAB-MS m/z459 [M+H]+, 21h; FAB-MS m/z 489 [M+H]+, 21i; FAB-MS m/z 493[M+H]+, 21j; FAB-MS m/z 513 [M+H]+, 21k; FAB-MS m/z 521[M+H]+, 21l; FAB-MS m/z 472 [M+H]+, 21m; FAB-MS m/z 457 [M+H]+, 21n; FAB-MS m/z 471 [M+H]+, 21o; FAB-MS m/z 430[M+H]+, 21p; FAB-MS m/z 444 [M+H]+, 21q; FAB-MS m/z 444[M+H]+, 21r; FAB-MS m/z 444 [M+H]+, 21s; FAB-MS m/z 460 [M+H]+, 21t; FAB-MS m/z 449 [M]+, 21u; FAB-MS m/z 433[M+H]+, 21v; FAB-MS m/z 469 [M+H]+, 21w; FAB-MS m/z 480[M+H]+. Compound 21f was obtained from 2-amino-5-chloro-3-hydroxy-40-methoxybenzanilide using the methods described forthe synthesis of compound 19 as a colorless solid (423 mg, 56%):
	With ethyl acetate; at 70℃; for 24h;	General procedure: A flame-dried 25 mL reaction tube was placed with a stirring bar. Then, Nmethylisatoicanhydride (2 mmol), amine compounds (1.0 equiv) and EtOAc (4.0 mL)were added. The resulting mixture was stirred at 70 for 24 hours. Then, the reactionmixture was concentrated and purified by column chromatography (silica gel) to givethe target product A. A flame-dried 100 mL round-bottom flask was placed with a stirring bar. Then, A (1.5 mol), R2B(OH)2 (1.5 equiv), CuCl (20 mol%), Et3N (50 mol%) and MeOH (30 mL)were added, The resulting mixture was stirred at room temperature for 12 hours. Then,the reaction mixture was filtered, concentrated, and purified by columnchromatography (silica gel) to give the target product B.

References: [1]Bollettino Chimico Farmaceutico,2002,vol. 141,p. 8 - 14.
[2]Chemical Communications,2014,vol. 50,p. 6471 - 6474.
[3]Journal fur praktische Chemie (Leipzig 1954),1901,vol. <2> 63,p. 244.
Journal fuer Praktische Chemie (Leipzig),1902,vol. <2> 65,p. 533.
[4]Journal of Medicinal Chemistry,1991,vol. 34,p. 1505 - 1508.
[5]Bioorganic and Medicinal Chemistry,2015,vol. 23,p. 277 - 289.
[6]Journal of Organic Chemistry,2015,vol. 80,p. 4736 - 4742.
[7]Journal of Organic Chemistry,2019,vol. 84,p. 1596 - 1604.
[8]Chinese Chemical Letters,2022,vol. 33,p. 1559 - 1562.

2
[ 22312-62-5 ]
3-(m-tolyl)benzo[d][1,2,3]triazin-4(3H)-one [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	With tert.-butylnitrite; tetra-(n-butyl)ammonium iodide; In acetonitrile; at 60℃; for 12h;Sealed tube;	General procedure: 2-aminobenzamides (1a-z, 0.2 mmol), TBAI (3.7 mg, 0.01 mol), tert-butylnitrite (72 μL, 0.6 mmol) and CH3CN (2.0 mL) were successively addedto a 10 mL of sealed tube. The mixture was stirred at 60 C for 12 h at air. The solution was then cooled to r.t. and evaporated undervaccum. The residue was purified by column chromatography on silica gel (petroleum ether/ethyl acetate = 6:1 to 3:1) to afford the desired products3a-z.
82%	With tert.-butylnitrite; tetra-(n-butyl)ammonium iodide; In acetonitrile; at 60℃; for 12h;Green chemistry;	The reaction flask was added with 1c (2mmol, 452mg), and added tert-butyl nitrite (6mmol, 0.72mL), followed by tetrabutylammonium iodide (5mol%,37 mg ) and acetonitrile (20mL). Then the system was heated for 12 hours at 60 deg C. air, vacuum spin dry acetateAfter the nitrile with petroleum ether / ethyl acetate = 6/1 mixed solvent of a simple column chromatography to give the product 2c, yield 82%. yellowSolid color

References: [1]Tetrahedron Letters,2016,vol. 57,p. 4170 - 4173.
[2]Patent: CN105418525,2016,A .Location in patent: Paragraph 0021; 0022; 0023.
[3]Advanced Synthesis and Catalysis,2016,vol. 358,p. 212 - 217.
[4]Journal fur praktische Chemie (Leipzig 1954),1901,vol. <2>63,p. 285.

3
[ 72651-98-0 ]
[ 22312-62-5 ]
[ 133040-65-0 ]

References: [1]Journal of Medicinal Chemistry,1991,vol. 34,p. 1505 - 1508.

4
[ 50623-64-8 ]
[ 22312-62-5 ]

Yield	Reaction Conditions	Operation in experiment
	With iron; ammonium chloride; In ethanol; water; at 90℃; for 3h;	General procedure: Compound c (15 mmol), reductive iron powder (15 mmol),NH4Cl (45 mmol), and ethanol aqueoussolution (75%, 60 mL) were added in a flask. The reaction proceeded with refluxing for 3 h, at 90 C.When the reaction finished, the mixtures were cooled to room temperature and extracted with CH2Cl2(3 x 20 mL) and the organic phase was evaporated in a vacuum to obtain compound d.

References: [1]Journal of Medicinal Chemistry,2008,vol. 51,p. 2400 - 2411.
[2]Journal of Medicinal Chemistry,1986,vol. 29,p. 1534 - 1537.
[3]Molecules,2020,vol. 25.

5
[ 22312-62-5 ]
[ 123-11-5 ]
[ 143424-10-6 ]

References: [1]Pharmaceutical Chemistry Journal,1992,vol. 26,p. 245 - 249.
Khimiko-Farmatsevticheskii Zhurnal,1992,vol. 26,p. 48 - 51.

6
[ 22312-62-5 ]
[ 120-14-9 ]
[ 143424-19-5 ]

References: [1]Pharmaceutical Chemistry Journal,1992,vol. 26,p. 245 - 249.
Khimiko-Farmatsevticheskii Zhurnal,1992,vol. 26,p. 48 - 51.

7
[ 22312-62-5 ]
[ 613-45-6 ]
[ 143424-14-0 ]

References: [1]Pharmaceutical Chemistry Journal,1992,vol. 26,p. 245 - 249.
Khimiko-Farmatsevticheskii Zhurnal,1992,vol. 26,p. 48 - 51.

Yield	Reaction Conditions	Operation in experiment
		(2ac) 2-Amino-N-(3-methylphenyl)benzamide, m.p. 115-117 C., utilizing 3-methylaniline; (2ad) 2-Amino-N-(3-benzoylphenyl)benzamide, as a yellow oil, utilizing (3-aminophenyl)phenylmethanone; (2ae) 2-Amino-N-[(3-aminocarbonyl)phenyl]benzamide, utilizing 3-aminobenzamide. Intermediate 2af: 2-Amino-N-(4-methylphenyl)-6-methylbenzamide

9
[ 22312-62-5 ]
[ 79-11-8 ]
[ 497066-79-2 ]

References: [1]Bollettino Chimico Farmaceutico,2002,vol. 141,p. 8 - 14.

10
[ 22312-62-5 ]
4-<i>m</i>-tolyl-1,2-dihydro-benzo[<i>e</i>][1,4]diazepine-3,5-dione [ No CAS ]

References: [1]Bollettino Chimico Farmaceutico,2002,vol. 141,p. 8 - 14.

11
[ 108-44-1 ]
[ 22312-62-5 ]

References: [1]Journal of Medicinal Chemistry,1986,vol. 29,p. 1534 - 1537.

12
[ 610-14-0 ]
3-<β-amino-ethyl>-indole-carboxylic acid-(2) [ No CAS ]
[ 22312-62-5 ]

References: [1]Journal of Medicinal Chemistry,1986,vol. 29,p. 1534 - 1537.

13
[ 22312-62-5 ]
[ 139602-71-4 ]

References: [1]Pharmaceutical Chemistry Journal,1992,vol. 26,p. 245 - 249.
Khimiko-Farmatsevticheskii Zhurnal,1992,vol. 26,p. 48 - 51.

14
[ 22312-62-5 ]
[ 139602-66-7 ]

References: [1]Pharmaceutical Chemistry Journal,1992,vol. 26,p. 245 - 249.
Khimiko-Farmatsevticheskii Zhurnal,1992,vol. 26,p. 48 - 51.

15
[ 22312-62-5 ]
[ 143424-29-7 ]

References: [1]Pharmaceutical Chemistry Journal,1992,vol. 26,p. 245 - 249.
Khimiko-Farmatsevticheskii Zhurnal,1992,vol. 26,p. 48 - 51.

16
[ 22312-62-5 ]
[ 143424-24-2 ]

References: [1]Pharmaceutical Chemistry Journal,1992,vol. 26,p. 245 - 249.
Khimiko-Farmatsevticheskii Zhurnal,1992,vol. 26,p. 48 - 51.

17
[ 22312-62-5 ]
1-(3,4-Dimethoxy-benzyl)-2-methyl-4-oxo-3-m-tolyl-3,4-dihydro-quinazolin-1-ium; perchlorate [ No CAS ]

References: [1]Pharmaceutical Chemistry Journal,1992,vol. 26,p. 245 - 249.
Khimiko-Farmatsevticheskii Zhurnal,1992,vol. 26,p. 48 - 51.

18
[ 22312-62-5 ]
1-(2,4-Dimethoxy-benzyl)-2-methyl-4-oxo-3-m-tolyl-3,4-dihydro-quinazolin-1-ium; perchlorate [ No CAS ]

References: [1]Pharmaceutical Chemistry Journal,1992,vol. 26,p. 245 - 249.
Khimiko-Farmatsevticheskii Zhurnal,1992,vol. 26,p. 48 - 51.

19
[ 118-92-3 ]
[ 108-44-1 ]
[ 22312-62-5 ]

Yield	Reaction Conditions	Operation in experiment
	With benzotriazol-1-ol; 1,2-dichloro-ethane; triethylamine; In N,N-dimethyl-formamide;	Step 1: Preparation of 2-amino-N-(3-methylphenyl)benzamide (64) To a solution of 2-aminobenzoic acid (290 mg) and 3-methylaniline (215 mg) in 10 mL of DMF was added 1-hydroxybenzotriazole (300 mg), EDC (400 mg) and triethylamine (500 μL). The resulting solution was stirred for 16 h. The reaction solution was partitioned with ethyl acetate and water. The ethyl acetate layer was extracted w/50 mL each of 5% citric acid, saturated sodium bicarbonate, saturated sodium chloride, dried over magnesium sulfate and concentrated in vacuo to afford the title compound as a solid.

References: [1]Patent: US5631280,1997,A .

20
[ 22312-62-5 ]
[ 183269-70-7 ]

Yield	Reaction Conditions	Operation in experiment
		Preparation of 2-[2(R)-Amino-3-mercaptopropylamino]-N-(3-methylphenyl)-benzamide trifluoroacetate (65) The title compound was prepared from 64 using the method described in Steps 3 and 4 of Example 1, except that the ion exchange with BioRad AG 3-X4 was omitted. Analysis Calculated for C17 H21 N3 OS·1.15 TFA·0.3 H2 O: C, 51.28; H, 5.07; N, 9.30; Found: C, 51.29; H, 5.04; N, 9.29.

References: [1]Patent: US5631280,1997,A .

21
[ 22312-62-5 ]
[ 78-39-7 ]
[ 22288-99-9 ]

Yield	Reaction Conditions	Operation in experiment
70%	for 5h;Heating / reflux;	A mixture of commercially available 49 (2 g, 0.009 mol) and 1,1,1-triethoxy-ethane (5.2 mL, 0.028 mol) were heated for 5 hours. The reaction mixture was poured into water, washed with water yielding 50 (70%). After recrystallization from EtOH the crude material was used in next step without further purification.
	for 5h;Heating;	2-Methyl-3-m-tolyl-3H-quinazolin-4-one (50): A mixture of commercially available 49 (2 g, 0.009 mol) and 1,1,1-triethoxy-ethane (5.2 mL, 0.028 mol) were heated for 5 hours. The reaction mixture was poured into water, washed with water yielding 50 (70%). After recrystallization from EtOH the crude material was used in next step without further purification.

References: [1]Patent: US2007/179164,2007,A1 .Location in patent: Page/Page column 50; 51.
[2]Patent: US9486455,2016,B2 .Location in patent: Page/Page column 149.

22
[ 118-92-3 ]
[ 22312-62-5 ]

References: [1]Medicinal Chemistry Research,2012,vol. 21,p. 293 - 307.

23
[ 108-44-1 ]
[ 21563-73-5 ]
[ 22312-62-5 ]

References: [1]Medicinal Chemistry Research,2012,vol. 21,p. 293 - 307.

24
[ 22312-62-5 ]
[ 127-19-5 ]
[ 94064-25-2 ]

References: [1]Chemical Communications,2014,vol. 50,p. 6471 - 6474.

25
[ 22312-62-5 ]
4-(4-methyl-1,4-diazepan-1-yl)benzoyl chloride hydrochloride [ No CAS ]
C₂₇H₃₀N₄O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
		General procedure: 7.1.13. Solution-phase synthesis of library compounds 21Isatoic anhydride (20) (0.1 mmol) was partitioned into reaction vials and treated with aniline (0.10 mmol) in toluene (1.0 mL) at 100 C for 12 h. The mixture in each vessel was allowed to coolto ambient temperature, and the solvent was removed under reduced pressure. The residue in each vessel was dissolved in pyridine(1.0 mL) and treated with compound 37 (0.10 mol) at ambient temperature for 12 h. The mixture was then treated with polymer-bound tris(2-aminoethyl)amine for 12 h and filtered off. The filtrate was collected in vials and the solutions were evaporatedin vacuo to afford anthranilamide derivatives 21, which were analyzed by HPLC and MS. 21a; FAB-MS m/z 443 [M+H]+, 21b; FABMS m/z 443 [M+H]+, 21c; FAB-MS m/z 443 [M+H]+, 21d; FAB-MS m/z 463 [M+H]+, 21e; FAB-MS m/z 463 [M+H]+, 21g; FAB-MS m/z459 [M+H]+, 21h; FAB-MS m/z 489 [M+H]+, 21i; FAB-MS m/z 493[M+H]+, 21j; FAB-MS m/z 513 [M+H]+, 21k; FAB-MS m/z 521[M+H]+, 21l; FAB-MS m/z 472 [M+H]+, 21m; FAB-MS m/z 457 [M+H]+, 21n; FAB-MS m/z 471 [M+H]+, 21o; FAB-MS m/z 430[M+H]+, 21p; FAB-MS m/z 444 [M+H]+, 21q; FAB-MS m/z 444[M+H]+, 21r; FAB-MS m/z 444 [M+H]+, 21s; FAB-MS m/z 460 [M+H]+, 21t; FAB-MS m/z 449 [M]+, 21u; FAB-MS m/z 433[M+H]+, 21v; FAB-MS m/z 469 [M+H]+, 21w; FAB-MS m/z 480[M+H]+. Compound 21f was obtained from 2-amino-5-chloro-3-hydroxy-40-methoxybenzanilide using the methods described forthe synthesis of compound 19 as a colorless solid (423 mg, 56%):

References: [1]Bioorganic and Medicinal Chemistry,2015,vol. 23,p. 277 - 289.

26
[ 22312-62-5 ]
[ 80-43-3 ]
[ 94064-25-2 ]

References: [1]Journal of Organic Chemistry,2015,vol. 80,p. 4736 - 4742.

27
[ 22312-62-5 ]
2-[2-(2-hydroxy-3-methoxyphenyl)vinyl]-3-m-tolyl-3H-quinazolin-4-one [ No CAS ]

References: [1]Patent: US9486455,2016,B2 .

28
[ 22312-62-5 ]
[ 119-67-5 ]
C₂₂H₁₆N₂O₂ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%	With choline chloride; toluene-4-sulfonic acid; at 20℃; for 1h;Green chemistry;	General procedure: To a mixture of 2-formylbenzoic acid (1; 1 mmol) and the appropriate amine 2, 4, or 6 (1 mmol) was added the DES (1.5 g), prepared from ChCl and TsOH.31 The resulting mixture was stirred at r.t. until the starting materials were completely consumed (TLC). The reaction mass was then diluted with H2O (5mL), and the desired product, obtained as a precipitate, was isolated by filtration and crystallized from the appropriate solvent.The filtrate was evaporated under vacuum at 70 C for 2 h, and the residual DES was reused in further reaction cycles.

References: [1]Synlett,2016,vol. 27,p. 2807 - 2810.

29
[ 625-95-6 ]
[ 28144-70-9 ]
[ 22312-62-5 ]

References: [1]Chemistry - A European Journal,2017,vol. 23,p. 13676 - 13683.

30
[ 22312-62-5 ]
[ 7188-38-7 ]
[ 98-80-6 ]
[ 37856-15-8 ]

References: [1]Journal of Organic Chemistry,2018,vol. 83,p. 9201 - 9209.

31
[ 5344-90-1 ]
[ 108-44-1 ]
[ 22312-62-5 ]

References: [1]Journal of Organic Chemistry,2018,vol. 83,p. 9201 - 9209.

32
[ 22312-62-5 ]
1-phenyl-2-(m-tolyl)-1H-indazol-3(2H)-one [ No CAS ]

References: [1]Journal of Organic Chemistry,2019,vol. 84,p. 1596 - 1604.

33
[ 22312-62-5 ]
[ 98-80-6 ]
C₂₀H₁₈N₂O [ No CAS ]

References: [1]Journal of Organic Chemistry,2019,vol. 84,p. 1596 - 1604.

34
[ 22312-62-5 ]
[ 22288-99-9 ]

References: [1]Green Chemistry,2020,vol. 22,p. 3506 - 3511.

35
[ 22312-62-5 ]
[ 107-21-1 ]
[ 94064-25-2 ]

References: [1]Green Chemistry,2020,vol. 22,p. 3506 - 3511.

Historical Records

Technical Information

• Acyl Group Substitution • Benzylic Oxidation • Birch Reduction • Blanc Chloromethylation • Buchwald-Hartwig C-N Bond and C-O Bond Formation Reactions • Chan-Lam Coupling Reaction • Complex Metal Hydride Reductions • Friedel-Crafts Reaction • Hydride Reductions • Hydrogenolysis of Benzyl Ether • Lawesson's Reagent • Leuckart-Wallach Reaction • Mannich Reaction • Petasis Reaction • Preparation of Alkylbenzene • Preparation of Amines • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Specialized Acylation Reagents-Carbodiimides and Related Reagents • Specialized Acylation Reagents-Ketenes • Specialized Acylation Reagents-Vilsmeier Reagent • Ugi Reaction • Vilsmeier-Haack Reaction

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[ 22312-62-5 ]

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P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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CAS No.: 22312-62-5

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