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Chemical Structure| 220227-84-9 Chemical Structure| 220227-84-9

Structure of 220227-84-9

Chemical Structure| 220227-84-9

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Product Details of [ 220227-84-9 ]

CAS No. :220227-84-9
Formula : C7H4ClF3O3S
M.W : 260.62
SMILES Code : O=S(C1=CC=CC(OC(F)(F)F)=C1)(Cl)=O
MDL No. :MFCD01091016
InChI Key :DODDSXTWDSJCDN-UHFFFAOYSA-N
Pubchem ID :2777218

Safety of [ 220227-84-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3265
Packing Group:

Application In Synthesis of [ 220227-84-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 220227-84-9 ]

[ 220227-84-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 220227-84-9 ]
  • [ 832710-65-3 ]
  • [ 1349632-98-9 ]
YieldReaction ConditionsOperation in experiment
49% With triethylamine; In dichloromethane; for 16h; 2,8-Diazaspiro[4.5]decan-1 -one hydrogen chloride (100 mg, 0.524 mmol) was dissolved in dichloromethane (5 mL) and triethylamine (0.146 mL, 1.047 mmol). Then 3-[(trifluoromethyl)oxy]benzenesulfonyl chloride (0.098 mL, 0.577 mmol) was added and stirred for 16 h. The reaction mixture was concentrated in vacuo and the resulting residue was purified by MDAP to give 8-({3-[(trifluoromethyl)oxy]phenyl}- sulfonyl)-2,8-diazaspiro[4.5]decan-1 -one (99 mg, 0.259 mmol, 49% yield) as a white solid. 1 H NMR (400 MHz, DMSO-d6) delta ppm 1 .44 (ddd, J=13.41 , 3.55, 3.32 Hz, 2 H) 1 .60 - 1 .71 (m, 2 H) 1 .76 (t, J=6.80 Hz, 2 H) 2.57 - 2.69 (m, 2 H) 3.09 (t, J=6.82 Hz, 2 H) 3.45 - 3.54 (m, 2 H) 7.60 (s, 1 H) 7.68 (dd, J=1.67, 0.79 Hz, 1 H) 7.74 - 7.83 (m, 3 H). MS ES+ve m/z 379 (M+H)
 

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