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Chemical Structure| 215734-58-0 Chemical Structure| 215734-58-0

Structure of 215734-58-0

Chemical Structure| 215734-58-0

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Product Details of [ 215734-58-0 ]

CAS No. :215734-58-0
Formula : C8H4F2N2
M.W : 166.13
SMILES Code : FC1=C(F)C=C2N=CC=NC2=C1
MDL No. :MFCD01176360

Safety of [ 215734-58-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P264-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P330-P332+P313-P337+P313-P362-P403+P233-P405-P501

Application In Synthesis of [ 215734-58-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 215734-58-0 ]

[ 215734-58-0 ] Synthesis Path-Downstream   1~2

  • 1
  • [ 603-76-9 ]
  • [ 215734-58-0 ]
  • 6,7-difluoro-2-(1-methyl-1H-indol-3-yl)quinoxaline [ No CAS ]
  • [ 78581-99-4 ]
  • [ 27065-95-8 ]
YieldReaction ConditionsOperation in experiment
36%; 12% With acetic acid; at 110℃; for 35h; Compound 1 (0.225 g, 1.35 mmol) was heated with1-methylindole (0.5 g, 3.8 mmol) in AcOH (3 mL) at 110C for 35 h, cooled, and stored at 20-25 for 12 h. The resultingprecipitate was filtered off and recrystallized from DMF. Yield of tris(1-methylindol-3-yl)methane (4a), 0.060 g (12%),mp 241-243C [6]. The PMR spectrum was published [6]. Mass spectrum (EI, 70 eV), m/z (Irel, %): 404 (29), 403 (M+, 100),402 (44), 272 (75), 271 (85), 257 (15).
  • 2
  • [ 95-20-5 ]
  • [ 215734-58-0 ]
  • 6,7-difluoro-2-(2-methyl-1H-indol-3-yl)quinoxaline [ No CAS ]
  • [ 602-04-0 ]
  • [ 78581-99-4 ]
YieldReaction ConditionsOperation in experiment
25%; 9% With acetic acid; at 110℃; for 35h; The reaction mixturewas evaporated in vacuo. The solid was worked up with EtOH (3-4 mL). The precipitate of tris(2-methylindol-3-yl)methane(4b) was filtered off and rinsed with EtOH. Yield 9%, mp > 300 (lit. [7] mp > 300). 1 NMR spectrum (400 MHz,DMSO-d6, , ppm, J/Hz): 1.92 (9, s, CH3), 6.09 (1, s, CH), 6.60 (3, ddd, J = 7.9, 7.2, 1.0, H-5), 6.84-6.90 (6, m,H-6, 7), 7.16 (3, dd, J = 7.9, 1.2, H-4), 10.37 (3, s, NH). Mass spectrum (EI, 70 eV), m/z (Irel, %): 404 (33), 403 (M+, 89),402 (22), 272 (75), 271 (15), 257 (86), 256 (32).
 

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