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Chemical Structure| 215597-35-6 Chemical Structure| 215597-35-6

Structure of 215597-35-6

Chemical Structure| 215597-35-6

Methyl 1-aminocyclobutanecarboxylate

CAS No.: 215597-35-6

4.5 *For Research Use Only !

Cat. No.: A273669 Purity: 98%

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Product Details of [ 215597-35-6 ]

CAS No. :215597-35-6
Formula : C6H11NO2
M.W : 129.16
SMILES Code : COC(=O)C1(N)CCC1
MDL No. :MFCD01318265
InChI Key :SGXOPTPGZBLQAY-UHFFFAOYSA-N
Pubchem ID :1502033

Safety of [ 215597-35-6 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 215597-35-6 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 215597-35-6 ]

[ 215597-35-6 ] Synthesis Path-Upstream   1~4

  • 1
  • [ 67-56-1 ]
  • [ 120728-10-1 ]
  • [ 215597-35-6 ]
YieldReaction ConditionsOperation in experiment
75% at 0℃; Reflux Stage 1: Methyl 1-aminocyclobutanecarboxylate
Concentrated H2SO4 (10 ml) was added at 0° C. to a solution of 1-(tert-butoxy-carbonylamino)-cyclobutane-1-carboxylic acid (9.29 mmol, 1 equiv.) in MeOH (30 ml), and the reaction was refluxed for 2 hours at 0° C.
The solvent was removed under reduced pressure.
The residue was taken up in distilled water, adjusted to pH 8-9 with saturated sodium hydrogen carbonate solution and extracted with ethyl acetate (2*200 ml).
The combined organic phases were washed with distilled water (2*150 ml) and saturated NaCl solution (2*50 ml) and dried over sodium sulfate.
The solvent was concentrated under reduced pressure to yield the desired product in the form of a white solid. Yield: 75percent
References: [1] Patent: US2010/173889, 2010, A1, . Location in patent: Page/Page column 34.
  • 2
  • [ 851662-64-1 ]
  • [ 215597-35-6 ]
References: [1] Tetrahedron Letters, 2005, vol. 46, # 15, p. 2659 - 2662.
[2] Tetrahedron, 2006, vol. 62, # 39, p. 9268 - 9279.
  • 3
  • [ 851662-59-4 ]
  • [ 215597-35-6 ]
References: [1] Tetrahedron, 2006, vol. 62, # 39, p. 9268 - 9279.
[2] Tetrahedron Letters, 2005, vol. 46, # 15, p. 2659 - 2662.
  • 4
  • [ 67-56-1 ]
  • [ 22264-50-2 ]
  • [ 215597-35-6 ]
References: [1] ACS Combinatorial Science, 2016, vol. 18, # 6, p. 330 - 336.
 

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