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Chemical Structure| 120728-10-1 Chemical Structure| 120728-10-1

Structure of 120728-10-1

Chemical Structure| 120728-10-1

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Product Details of [ 120728-10-1 ]

CAS No. :120728-10-1
Formula : C10H17NO4
M.W : 215.25
SMILES Code : O=C(C1(NC(OC(C)(C)C)=O)CCC1)O
MDL No. :MFCD02682623
InChI Key :ROVVUKFHORPDSM-UHFFFAOYSA-N
Pubchem ID :1512646

Safety of [ 120728-10-1 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 120728-10-1 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 120728-10-1 ]

[ 120728-10-1 ] Synthesis Path-Upstream   1~3

  • 1
  • [ 67-56-1 ]
  • [ 120728-10-1 ]
  • [ 215597-35-6 ]
YieldReaction ConditionsOperation in experiment
75% at 0℃; Reflux Stage 1: Methyl 1-aminocyclobutanecarboxylate
Concentrated H2SO4 (10 ml) was added at 0° C. to a solution of 1-(tert-butoxy-carbonylamino)-cyclobutane-1-carboxylic acid (9.29 mmol, 1 equiv.) in MeOH (30 ml), and the reaction was refluxed for 2 hours at 0° C.
The solvent was removed under reduced pressure.
The residue was taken up in distilled water, adjusted to pH 8-9 with saturated sodium hydrogen carbonate solution and extracted with ethyl acetate (2*200 ml).
The combined organic phases were washed with distilled water (2*150 ml) and saturated NaCl solution (2*50 ml) and dried over sodium sulfate.
The solvent was concentrated under reduced pressure to yield the desired product in the form of a white solid. Yield: 75percent
References: [1] Patent: US2010/173889, 2010, A1, . Location in patent: Page/Page column 34.
  • 2
  • [ 120728-10-1 ]
  • [ 74-88-4 ]
  • [ 880166-10-9 ]
References: [1] Patent: EP1995243, 2008, A1, . Location in patent: Page/Page column 18.
  • 3
  • [ 120728-10-1 ]
  • [ 1142211-17-3 ]
References: [1] Patent: WO2010/42850, 2010, A1, . Location in patent: Page/Page column 52-53; 67.
[2] Patent: WO2011/44501, 2011, A2, . Location in patent: Page/Page column 60; 76.
[3] Patent: WO2011/44498, 2011, A1, . Location in patent: Page/Page column 66, 80-81.
[4] Patent: WO2011/44538, 2011, A1, . Location in patent: Page/Page column 105-106.
[5] Patent: WO2009/67692, 2009, A1, . Location in patent: Page/Page column 187.
[6] Patent: WO2010/42851, 2010, A1, . Location in patent: Page/Page column 52-53; 67.
[7] Patent: WO2010/132777, 2010, A2, . Location in patent: Page/Page column 195; 48-49.
 

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