21345-01-7|5-Phenoxyisobenzofuran-1,3-dione| Ambeed

Size	Price	VIP Price	US Stock	Global Stock	In Stock
{[ item.pr_size ]}		Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}

US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days

{[ item.pr_size ]}

In Stock

- +

Please Login or Create an Account to: See VIP prices and availability

US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks

Quality Control of [ 21345-01-7 ] Purity: 98% SDS Specification

COA

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

NMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

CNMR

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

HPLC

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

LC-MS

Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.

1-2 Day Shipping
High Quality
Technical Support

Product Details of [ 21345-01-7 ]

CAS No. :	21345-01-7
Formula :	C₁₄H₈O₄
M.W :	240.21
SMILES Code :	O=C1OC(C2=C1C=CC(OC3=CC=CC=C3)=C2)=O
MDL No. :	MFCD00127685
InChI Key :	HDQBHDKNRKRCNH-UHFFFAOYSA-N
Pubchem ID :	12380384

Safety of [ 21345-01-7 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 21345-01-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 21345-01-7 ]

[ 21345-01-7 ] Synthesis Path-Downstream 1~27

1
[ 37951-15-8 ]
[ 21345-01-7 ]

Yield	Reaction Conditions	Operation in experiment
	With acetic anhydride; acetic acid; for 3.0h;Resolution of racemate;	Compound 2 (6.0 g) was dissolved in glacial acetic acid (60 mL) and acetic anhydride (60 mL) and heated to reflux for 3 hrs. The solvent was removed on a rotary evaporator to obtain Compound 3.
	With acetic anhydride; In acetic acid; for 3.0h;Reflux;	Compound 2 (6.0 g) was dissolved in glacial acetic acid (60 mL) and acetic anhydride (60 mL) and heated to reflux for 3 hrs. The solvent was removed on a rotary evaporator to obtain Compound 3.
	With acetic anhydride; acetic acid; for 3.0h;Reflux;	6.0 g of compound 2 was dissolved in 60 ml of glacial acetic acid and 60 ml of acetic anhydride, and the mixture was heated under reflux for 3 hours to obtain compound 3 after removal of the solvent.

References: [1]Journal of general chemistry of the USSR,1980,vol. 50,p. 1874 - 1878.
Zhurnal Obshchei Khimii,1980,vol. 50,p. 2313 - 2318.
[2]Patent: WO2013/13609,2013,A1 .Location in patent: Page/Page column 16.
[3]Patent: US2015/31721,2015,A1 .Location in patent: Paragraph 0146.
[4]Chemistry - A European Journal,2017,vol. 23,p. 10616 - 10625.
[5]Patent: TWI582078,2017,B .Location in patent: Paragraph 0145; 0151; 0152.

3
[ 21345-01-7 ]
[ 550-44-7 ]

Yield	Reaction Conditions	Operation in experiment
64%		The above results show that an exchange occurred between 4-phenoxy-N-methylphthalmide and phthalic anhydride, resulting in a 46% yield of N-methylphthalimide and a 64% yield of <strong>[21345-01-7]4-phenoxyphthalic anhydride</strong> or acid.

References: [1]Patent: US4128574,1978,A .

4
[ 21345-01-7 ]
[ 142-71-2 ]
[ 77447-50-8 ]

References: [1]Journal of general chemistry of the USSR,1980,vol. 50,p. 1874 - 1878.
J.Gen.Chem.USSR (Engl.Transl.),1980,vol. 50,p. 2313 - 2318.

5
[ 31643-49-9 ]
[ 21345-01-7 ]

References: [1]Patent: WO2013/13609,2013,A1 .
[2]Patent: US2015/31721,2015,A1 .
[3]Chemistry - A European Journal,2017,vol. 23,p. 10616 - 10625.
[4]Patent: TWI582078,2017,B .

6
[ 108-95-2 ]
[ 21345-01-7 ]

References: [1]Patent: WO2013/13609,2013,A1 .
[2]Patent: US2015/31721,2015,A1 .
[3]Chemistry - A European Journal,2017,vol. 23,p. 10616 - 10625.
[4]Patent: TWI582078,2017,B .

7
[ 21345-01-7 ]
[ 39687-95-1 ]
[ 1421312-31-3 ]

Yield	Reaction Conditions	Operation in experiment
9 g	With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20℃; for 1.0h;	Compounds 3 (6.0 g) and methyl isocyanoacetate (2.65 g) were dissolved in THF (60 mL). 3.54 g of DBU (CAS No. 6674-22-2) was added in drop-wise at room temperature and stirred for 1 hr. at room temperature. After extracted with ethyl acetate under alkaline conditions to remove the impurities, the pH value of the aqueous phase was adjusted to 3 with diluted HCL Extracted with ethyl acetate, washed with water and dried with anhydrous Na2S04 and fi ltered, the resulting organic phase was distilled on a rotary evaporator to obtain 9.0g of Compound 4.
9 g	With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20℃; for 1.0h;	Compounds 3 (6.0 g) and methyl isocyanoacetate (2.65 g) were dissolved in THF (60 mL). 3.54 g of DBU (CAS No. 6674-22-2) was added in drop-wise at room temperature and stirred for 1 hr. at room temperature. After extracted with ethyl acetate under alkaline conditions to remove the impurities, the pH value of the aqueous phase was adjusted to 3 with diluted HCl. Extracted with ethyl acetate, washed with water and dried with anhydrous Na2SO4 and filtered, the resulting organic phase was distilled on a rotary evaporator to obtain 9.0 g of Compound 4.
9 g	With 1,8-diazabicyclo[5.4.0]undec-7-ene; In tetrahydrofuran; at 20℃; for 1.0h;	Compound 3 (6.0 g) and 2.65 g of methyl isocyanoacetate were dissolved in 60 ml of tetrahydrofuran and 3.54 g of DBU (CAS Registry No. 6674-22-2) was added dropwise at room temperature and stirred at room temperature 1 hourThe mixture was extracted with ethyl acetate to remove impurities. The aqueous phase was adjusted to pH = 3 with dilute hydrochloric acid, extracted with ethyl acetate, washed with water and dried over anhydrous Na2SO4. After removal of the solvent, 9.0 g of compound 4 was obtained.

References: [1]Patent: WO2013/13609,2013,A1 .Location in patent: Page/Page column 16.
[2]Patent: US2015/31721,2015,A1 .Location in patent: Paragraph 0147.
[3]Patent: TWI582078,2017,B .Location in patent: Paragraph 0145; 0153; 0154.

8
[ 38791-62-7 ]
[ 21345-01-7 ]

References: [1]Patent: WO2013/13609,2013,A1 .
[2]Patent: US2015/31721,2015,A1 .
[3]Chemistry - A European Journal,2017,vol. 23,p. 10616 - 10625.
[4]Patent: TWI582078,2017,B .

9
[ 21345-01-7 ]
[(4-hydroxy-1-methyl-7-phenoxy-isoquinoline-3-carbonyl)-amino]-acetic acid [ No CAS ]

References: [1]Patent: WO2013/13609,2013,A1 .
[2]Patent: US2015/31721,2015,A1 .
[3]Patent: TWI582078,2017,B .

10
[ 21345-01-7 ]
[ 1421312-32-4 ]

References: [1]Patent: WO2013/13609,2013,A1 .
[2]Patent: US2015/31721,2015,A1 .
[3]Patent: CN112661699,2021,A .

11
[ 21345-01-7 ]
[ 1421312-33-5 ]

References: [1]Patent: WO2013/13609,2013,A1 .
[2]Patent: US2015/31721,2015,A1 .
[3]Patent: CN112661699,2021,A .

12
[ 21345-01-7 ]
[ 1421312-34-6 ]

References: [1]Patent: WO2013/13609,2013,A1 .
[2]Patent: US2015/31721,2015,A1 .
[3]Patent: TWI582078,2017,B .
[4]Patent: CN112661699,2021,A .

13
[ 21345-01-7 ]
[ 1421312-35-7 ]

References: [1]Patent: WO2013/13609,2013,A1 .
[2]Patent: US2015/31721,2015,A1 .
[3]Patent: TWI582078,2017,B .

14
[ 21345-01-7 ]
[ 1421312-36-8 ]

References: [1]Patent: WO2013/13609,2013,A1 .
[2]Patent: US2015/31721,2015,A1 .
[3]Patent: TWI582078,2017,B .

15
[ 21345-01-7 ]
4-(phenoxy)-N-hydroxyphthalimide [ No CAS ]

References: [1]Chemistry - A European Journal,2017,vol. 23,p. 10616 - 10625.

16
[ 21345-01-7 ]
[ 676-58-4 ]
C₁₅H₁₂O₄ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
85%	In tetrahydrofuran; at -10 - 0℃;Inert atmosphere;	A three-necked flask was charged with compound formula 1 (24.02 g, 100 mmol) and tetrahydrofuran (120 mL),Dissolve with stirring, cool to -10 0 and switch nitrogen 3 times under vacuum.Under the protection of nitrogen, a methylmagnesium chloride tetrahydrofuran solution (2.0M, 55mL) was slowly dropped into the reaction bottle, and the reaction was kept warm for 2 to 4 hours after the dropping was completed.At the end of the reaction, 1 mol / L diluted hydrochloric acid (240 mL) was added to quench the reaction.The aqueous phase was extracted twice with ethyl acetate (120 mL).The combined organic phases were washed once with saturated brine (120 mL), and dried over anhydrous sodium sulfate.After concentration, it was recrystallized from a mixed solvent of petroleum ether and ethyl acetate to obtain Compound 2 (21.78 g, 85%).

References: [1]Patent: CN110526813,2019,A .Location in patent: Paragraph 0042-0044.

17
[ 21345-01-7 ]
ethyl 4-hydroxy-1-methyl-7-phenoxy-3-isoquinolinecarboxylate [ No CAS ]