Structure of 28281-76-7
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The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
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CAS No. : | 28281-76-7 |
Formula : | C9H6O4 |
M.W : | 178.14 |
SMILES Code : | COC2=CC=C1C(OC(C1=C2)=O)=O |
MDL No. : | MFCD02670942 |
InChI Key : | INEIVXABODMRMQ-UHFFFAOYSA-N |
Pubchem ID : | 639748 |
GHS Pictogram: |
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Signal Word: | Warning |
Hazard Statements: | H302-H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
Num. heavy atoms | 13 |
Num. arom. heavy atoms | 6 |
Fraction Csp3 | 0.11 |
Num. rotatable bonds | 1 |
Num. H-bond acceptors | 4.0 |
Num. H-bond donors | 0.0 |
Molar Refractivity | 42.68 |
TPSA ? Topological Polar Surface Area: Calculated from |
52.6 Ų |
Log Po/w (iLOGP)? iLOGP: in-house physics-based method implemented from |
1.41 |
Log Po/w (XLOGP3)? XLOGP3: Atomistic and knowledge-based method calculated by |
1.57 |
Log Po/w (WLOGP)? WLOGP: Atomistic method implemented from |
1.01 |
Log Po/w (MLOGP)? MLOGP: Topological method implemented from |
0.98 |
Log Po/w (SILICOS-IT)? SILICOS-IT: Hybrid fragmental/topological method calculated by |
1.82 |
Consensus Log Po/w? Consensus Log Po/w: Average of all five predictions |
1.36 |
Log S (ESOL):? ESOL: Topological method implemented from |
-2.21 |
Solubility | 1.1 mg/ml ; 0.00618 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (Ali)? Ali: Topological method implemented from |
-2.28 |
Solubility | 0.924 mg/ml ; 0.00519 mol/l |
Class? Solubility class: Log S scale |
Soluble |
Log S (SILICOS-IT)? SILICOS-IT: Fragmental method calculated by |
-2.59 |
Solubility | 0.456 mg/ml ; 0.00256 mol/l |
Class? Solubility class: Log S scale |
Soluble |
GI absorption? Gatrointestinal absorption: according to the white of the BOILED-Egg |
High |
BBB permeant? BBB permeation: according to the yolk of the BOILED-Egg |
Yes |
P-gp substrate? P-glycoprotein substrate: SVM model built on 1033 molecules (training set) |
No |
CYP1A2 inhibitor? Cytochrome P450 1A2 inhibitor: SVM model built on 9145 molecules (training set) |
Yes |
CYP2C19 inhibitor? Cytochrome P450 2C19 inhibitor: SVM model built on 9272 molecules (training set) |
No |
CYP2C9 inhibitor? Cytochrome P450 2C9 inhibitor: SVM model built on 5940 molecules (training set) |
No |
CYP2D6 inhibitor? Cytochrome P450 2D6 inhibitor: SVM model built on 3664 molecules (training set) |
No |
CYP3A4 inhibitor? Cytochrome P450 3A4 inhibitor: SVM model built on 7518 molecules (training set) |
No |
Log Kp (skin permeation)? Skin permeation: QSPR model implemented from |
-6.27 cm/s |
Lipinski? Lipinski (Pfizer) filter: implemented from |
0.0 |
Ghose? Ghose filter: implemented from |
None |
Veber? Veber (GSK) filter: implemented from |
0.0 |
Egan? Egan (Pharmacia) filter: implemented from |
0.0 |
Muegge? Muegge (Bayer) filter: implemented from |
1.0 |
Bioavailability Score? Abbott Bioavailability Score: Probability of F > 10% in rat |
0.55 |
PAINS? Pan Assay Interference Structures: implemented from |
0.0 alert |
Brenk? Structural Alert: implemented from |
2.0 alert: heavy_metal |
Leadlikeness? Leadlikeness: implemented from |
No; 1 violation:MW<1.0 |
Synthetic accessibility? Synthetic accessibility score: from 1 (very easy) to 10 (very difficult) |
1.85 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
99% | With acetic anhydride; In tetrahydrofuran; for 4h;Heating / reflux; | Acetic anhydride (40 ml) was added to a mixture of <strong>[1885-13-8]4-methoxyphthalic acid</strong> (30.8 g, 0.16 mol) in anhydrous tetrahydrofuran (150 ml) and the mixture was strirred and held at reflux for 4 hours. Upon cooling to room temperature the solvent was removed in vacuo to afford 4-methoxyphthalic anhydride (27.8 g, 99%) as an off white solid. 1H NMR (DMSO-d6) 8.02 (1 H, d), 7.59 (1 H, d), 7.49 (1 H, dd), 3.97 (3H, s). MS: [M+H]+ 179. |
99% | With acetic anhydride; In tetrahydrofuran; for 4h;Heating / reflux; | Acetic anhydride (40 ml) was added to a mixture of <strong>[1885-13-8]4-methoxyphthalic acid</strong> (30.8 g, 0.16 mol) in anhydrous tetrahydrofuran (150 ml) and the mixture was strirred and held at reflux for 4 hours. <n="227"/>Upon cooling to room temperature the solvent was removed in vacuo to afford 4-methoxyphthalic anhydride (27.8 g, 99%) as an off white solid. 1H NMR (DMSOd6) 8.02 (1 H1 d), 7.59 (1 H, d), 7.49 (1H, dd), 3.97 (3H1 s). MS: [M+H]+ 179. |
99% | With acetic anhydride; In tetrahydrofuran; for 4h;Heating / reflux; | Acetic anhydride (40 ml) was added to a mixture of <strong>[1885-13-8]4-methoxyphthalic acid</strong> (30.8 g, 0.16 mol) in anhydrous tetrahydrofuran (150 ml) and the mixture was strirred and held at reflux for 4 hours. Upon cooling to room temperature the solvent was removed in vacuo to afford 4-methoxyphthalic anhydride (27.8 g, 99%) as an off white solid. 1H NMR (DMSO-d6) 8.02 (1 H, d), 7.59 (1 H, d), 7.49 (1 H, dd), 3.97 (3H, s). MS: [M+H]+ 179. |
99% | With acetic anhydride; In tetrahydrofuran; for 4h;Heating / reflux; | Acetic anhydride (40 ml) was added to a mixture of <strong>[1885-13-8]4-methoxyphthalic acid</strong> (30.8 g, 0.16 mol) in anhydrous tetrahydrofuran (150 ml) and the mixture was strirred and held at reflux for 4 hours. Upon cooling to room temperature the solvent was removed in vacuo to afford 4-methoxyphthalic anhydride (27.8 g, 99%) as an off white solid. 1H NMR (DMSO-d6) 8.02 (1 H, d), 7.59 (1 H, d), 7.49 (1 H1 dd), 3.97 (3H, s). MS: [M+H]+ 179. |
99% | With acetic anhydride; In tetrahydrofuran; for 4h;Reflux; | Acetic anhydride (40 ml) was added to a mixture of <strong>[1885-13-8]4-methoxyphthalic acid</strong> (30.8 g, 0.16 mol) in anhydrous tetrahydrofuran (150 ml) and the mixture was stirred and held at reflux for 4 hours. Upon cooling to room temperature the solvent was removed in vacuo to afford 4-methoxyphthalic anhydride (27.8 g, 99%) as an off white solid. 1H NMR (DMSO-d6) 8.02 (1H, d), 7.59 (1H, d), 7.49 (1H, dd), 3.97 (3H, s). MS: [M+H]+ 179. |
98% | In acetic anhydride; for 18h;Reflux; | Step 4: Preparation of 5-methoxyisobenzofuran-1,3-dione The compound prepared in step 3 above (0.23 g, 1.2 mmol) was dissolved in 4 ml of acetic anhydride. The prepared solution was heated under reflux for 18 hours. The temperature of the solution was cooled down to room temperature, followed by concentration by rotary evaporation. The obtained residue was purified by flash column chromatography. As a result, a target compound was obtained (0.21 g, 98%). 1H NMR (DMSO-d6, 500 MHz) delta 7.99 (d, J=8.4 Hz, 1H), 7.58 (d, J=2.3 Hz, 1H), 7.48 (dd, J=8.5, 2.3 Hz, 1H), 3.97 (s, 3H). 13C NMR (DMSO-d6, 125 MHz) delta 165.7, 163.1, 162.7, 134.0, 127.2, 122.9, 122.7, 109.3, 56.7. |
78% | With 1,4-diaza-bicyclo[2.2.2]octane; thionyl chloride; In dichloromethane; at 0 - 20℃; for 0.833333h; | 1 ,4-Diazabicyclic[2,2,2]octane (336 mg, 3 mmol) was dissolved in anhydrous dichloromethane (3 ml_) and then stirred for five minutes while slowly adding distilled thionyl chloride (0.2 ml_, 3 mmol) at O0C. And then,<strong>[1885-13-8]4-methoxyphthalic acid</strong> (200 mg, 1 mmol) was slowly added dropwise at room temperature for 50 minutes. 10% sodium bicarbonate was added to neutralize the reaction solution and the resultant was extracted with dichloromethane.Organic layers were dried with anhydrous sodium sulfate and filtered, and the filtrate was distilled under reduced pressure, separated and then purified by a column chromatography on silica gel (hexane/ethyl acetate=3:1), to obtain139 mg of the desired compound (yield 78%).1H NMR (300 MHz, CDCI3) delta 7.92 (d, J=5.6 Hz, 1 H) 7.43 (d, J=2.9, 1 H),7.36 (dd, J=11.2, 3.0 Hz, 1 H), 3.99 (s, 1 H). 13C NMR (75 Hz, CDCI3) delta 166.17, 163.00, 162.43, 134.14, 127.28,123.22, 123.98, 108.89, 56.44. |
58% | With 1,4-diaza-bicyclo[2.2.2]octane; thionyl chloride; In dichloromethane; at 20℃; for 2h; | To a mixture of <strong>[1885-13-8]4-methoxy-phthalic acid</strong> (1.8 g, 9.18 mmol), thionyl chloride (1.4 mL, 19.79 mmol) in CH2C12 (15 mL) is added DABCO (1.1 g, 9.81 mmol). The reaction mixture is stirred at room temperature for 2 hours. The reaction mixture is diluted with CH2C12 (100 mL), washed with H20 (75 mL x2), dried with Na2S04 and filtered. The filtrate is concentrated under reduced pressure to afford 5-methoxy-isobenzofuran-l,3- dione (950 mg, 58%). |
With acetic anhydride; In tetrahydrofuran; for 4h;Reflux; | The solution of <strong>[1885-13-8]4-methoxyphthalic acid</strong> (16 mmol) and Ac2O (0.4 mL) in 2 mL THF was refluxedfor 4 h. Once completed, the solvent was evaporated and the intermediate 4-methyl phthalic anhydridewas afforded. Then it was mixed with aniline (0.16 mL) in 5 mL acetic acid under reflux to afford thefinal product quantitively [27]. |
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