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Chemical Structure| 2038-91-7 Chemical Structure| 2038-91-7

Structure of 2038-91-7

Chemical Structure| 2038-91-7

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Product Details of [ 2038-91-7 ]

CAS No. :2038-91-7
Formula : C13H9Br
M.W : 245.11
SMILES Code : BrC1=CC2=C(C=C1)CC3=C2C=CC=C3
MDL No. :MFCD09842188

Safety of [ 2038-91-7 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501

Application In Synthesis of [ 2038-91-7 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 2038-91-7 ]

[ 2038-91-7 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 2038-91-7 ]
  • [ 15424-38-1 ]
  • C33H23N [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% With tris-(dibenzylideneacetone)dipalladium(0); sodium t-butanolate; XPhos; In toluene; at 100 - 110℃; for 2h;Inert atmosphere; 70(2) To the machine equipped with mechanical stirring, thermometer, After replacing the three-port reaction flask in the condenser with nitrogen, Add intermediate 24c (80mmol) in sequence, Intermediate 3 (85mmol), 300ml toluene, heated to reflux for 0.5h, Cool down to 70 - 80 C, Slowly add sodium tert-butoxide (120mmol), Pd2 (dba) 3 (0.2mmol), xphos (0.4mmol), After the system is stable, it is heated to 100 - 110 C for 2h. Reduce the temperature to 25 - 30 C, add 200ml of water, stir and separate with 100ml of toluene, and extract the aqueous phase once with 200ml of toluene. Separate the liquid, combine the organic phase, add 7g of anhydrous sodium sulfate to the organic phase, stir and dry, filter The organic phase was concentrated (-0.08 0.09MPa, 55 - 60C) until it could not come out. Filtration to obtain 70mmol intermediate 24d, yield 88%
 

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