Structure of 20348-21-4
*Storage: {[sel_prStorage]}
*Shipping: {[sel_prShipping]}
The BI-3802 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
4.5
*For Research Use Only !
Change View
Size | Price | VIP Price | US Stock |
Global Stock |
In Stock | ||
{[ item.pr_size ]} |
Inquiry
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} {[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.discount_usd) ]} {[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]} |
Inquiry {[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]} | Inquiry {[ item.pr_usastock ]} In Stock Inquiry - | {[ item.pr_chinastock ]} {[ item.pr_remark ]} In Stock 1-2 weeks - Inquiry - | Login | - + | Inquiry |
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 5-7 days
1-2weeks
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,item.mem_rate,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd,1,item.mem_rate,item.pr_is_large_size_no_price, item.pr_usd) ]}
Inquiry
{[ getRatePrice(item.pr_usd,item.pr_rate,1,item.pr_is_large_size_no_price, item.vip_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
{[ getRatePrice(item.pr_usd, 1,1,item.pr_is_large_size_no_price, item.pr_usd) ]}
In Stock
- +
Please Login or Create an Account to: See VIP prices and availability
US Stock: ship in 0-1 business day
Global Stock: ship in 2 weeks
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
Search for reports by entering the product batch number.
Batch number can be found on the product's label following the word 'Batch'.
CAS No. : | 20348-21-4 |
Formula : | C9H10N2O2 |
M.W : | 178.19 |
SMILES Code : | C1=CC=NC2=C1OC(C(=O)N2)(C)C |
MDL No. : | MFCD10000810 |
InChI Key : | DMLNXUUGRSBBBR-UHFFFAOYSA-N |
Pubchem ID : | 88501 |
GHS Pictogram: |
![]() |
Signal Word: | Warning |
Hazard Statements: | H315-H319-H335 |
Precautionary Statements: | P261-P305+P351+P338 |
* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
86% | With bromine; sodium carbonate; In dichloromethane; at 0 - 35℃; for 16h; | Step-(ii): Synthesis of 7-bromo-2.2-dimethyl-2H-pyridor3.2-biri.41oxazin-3(4H)-one (Intermediate- 18) To a stirred solution of 2,2-dimethyl-2H-pyrido[3,2-b][l ,4]oxazin-3(4H)-one (18.1) (2 g, 11.23 mmol) in DCM (20 mL) was added Na2C03 (3.57 g, 33.70 mmol) followed by bromine (0.92 mL, 17.97 mmol) at 0C and the reaction mixture was allowed to stir at 20- 35C for 16 h. Then the reaction mixture was diluted with ice water, obtained solid was filtered and washed with water to get the desired compound as a white solid (1.8 g, 86%); lU NMR (400MHz, DMSO-<) delta 11.39 (s, 1H), 8.04 (d, J=.9 Hz, 1H), 7.66 (d, /=1.4 Hz, 1H), 1.43 (s, 6H); LC-MS: 257.0 (M+l)+. |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
96.5% | With hydrogen; In methanol; at 65℃; for 24h; | To a 25 mL eggplant-shaped flask was added Raney nickel (0.02 g, 0.16 mmol) and anhydrous methanol (10 mL).Compound 4 (0.2 g, 0.77 mmol) was added and stirred to dissolve, and the hydrogen was passed through three times, and reacted at 65 C for 24 h.Dilute the diatomaceous earth, remove the methanol under reduced pressure, and obtain a lightPurple solid 136 mg; yield 96.5%; |
Yield | Reaction Conditions | Operation in experiment |
---|---|---|
63% | 2,2-Dimethyl-2H,3H,4H-pyrido[3,2-b][l,4]oxazin-3-one (40 mg, 0.22 mmol) was taken up in DMF (0.7 ml) in an ice-bath. Sodium hydride (10 mg, 60 wt%, 0.22 mmol) was added and the solution was stirred for 20 min at 0 C. A solution of 2-[2-(bromomethyl)-l,3-thiazol-5-yl]-5- (difluoromethyl)-l,3,4-oxadiazole (4a, 50 mg, 0.17 mmol) in DMF (0.5 ml) was then added dropwise at 0 C. The solution was stirred at room temperature for 4 h. TLC indicted that the reaction was complete (all the bromide was consumed). The reaction was quenched by adding water and the separated aqueous phase was extracted with EtOAc. The organic layer was collected, washed with brine and then filtered through MgSCE. The filtrate was concentrated, and the residue was purified on Combiflash (DCM/methanol gradient) to afford the title compound (42 mg, 63%) as a white powder. |
A331682 [1002726-62-6]
6-Amino-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Similarity: 0.99
A250760 [20348-19-0]
2-Methyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Similarity: 0.95
A790849 [20348-20-3]
2-Ethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Similarity: 0.92
A901713 [1196153-28-2]
6-Bromo-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Similarity: 0.91
A105591 [894852-01-8]
7-Bromo-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Similarity: 0.90
A331682 [1002726-62-6]
6-Amino-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Similarity: 0.99
A250760 [20348-19-0]
2-Methyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Similarity: 0.95
A790849 [20348-20-3]
2-Ethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Similarity: 0.92
A901713 [1196153-28-2]
6-Bromo-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Similarity: 0.91
A105591 [894852-01-8]
7-Bromo-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one
Similarity: 0.90