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Chemical Structure| 20017-68-9 Chemical Structure| 20017-68-9

Structure of 20017-68-9

Chemical Structure| 20017-68-9

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Product Details of [ 20017-68-9 ]

CAS No. :20017-68-9
Formula : C15H15Br
M.W : 275.18
SMILES Code : BrCCC(C1=CC=CC=C1)C1=CC=CC=C1
MDL No. :MFCD00044829
InChI Key :SLHSRCBFPHCSGL-UHFFFAOYSA-N
Pubchem ID :88333

Safety of [ 20017-68-9 ]

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of [ 20017-68-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 20017-68-9 ]

[ 20017-68-9 ] Synthesis Path-Downstream   1~1

  • 1
  • [ 832710-65-3 ]
  • [ 20017-68-9 ]
  • [ 832710-62-0 ]
YieldReaction ConditionsOperation in experiment
44.9% With potassium carbonate; In DMF (N,N-dimethyl-formamide); at 60℃; for 8h; To a mixture of 1. 49 g (7. 8 mmol) of 2, 8-diaza- spiro [4. 5] decan-l-one hydrochloride, 2. 39 g (8. 6 mmol) of 3, 3-diphenylpropyl bromide and 3. 23 g (23. 4 mmol) of potassium carbonate was added 40 mL of anhydrous DMF. The reaction mixture was stirred for 8 hours at 60C. Then 10 mL of water was added and the solution was extracted with DCM (2 x 100 mL). The combined organic layers were dried over sodium sulfate, filtered and evaporated in vacuo. The yellow crude oil was purified by flash chromatography on silica gel (DCM/methanol 100 : 0 to 90 : 10) and 8- (3, 3-diphenylpropyl)-2, 8-diaza- spiro [4. 5] decan-l-one was isolated as a pale yellow solid (1. 22 g, 44. 9%). 1H NMR (400 MHZ, DMSO-D6) : o [PPM] 7. 49 (br s, 1H), 7. 3-7. 22 (m, 8H), 7. 13 (m, 2H), 3. 97 (t, 1H), 3. 09 (t, 2H), 2. 67 (m, 2H), 2. 13 (m, 4H), 1. 86 (m, 4H), 1. 63 (t x d, 2H), 1. 25 (br d, 2H).
 

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