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Type HazMat fee for 500 gram (Estimated)
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Chemical Structure| 1918-77-0 Chemical Structure| 1918-77-0
Chemical Structure| 1918-77-0

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Product Details of 2-Thiopheneacetic acid

CAS No. :1918-77-0
Formula : C6H6O2S
M.W : 142.18
SMILES Code : O=C(O)CC1=CC=CS1
MDL No. :MFCD00005458
InChI Key :SMJRBWINMFUUDS-UHFFFAOYSA-N
Pubchem ID :15970

Safety of 2-Thiopheneacetic acid

GHS Pictogram:
Signal Word:Danger
Hazard Statements:H314
Precautionary Statements:P280-P305+P351+P338-P310
Class:8
UN#:3261
Packing Group:

Application In Synthesis of 2-Thiopheneacetic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1918-77-0 ]

[ 1918-77-0 ] Synthesis Path-Downstream   1~4

  • 1
  • [ 1918-77-0 ]
  • [ 372-19-0 ]
  • [ 931-53-3 ]
  • [ 5780-66-5 ]
  • [ 1395081-24-9 ]
  • 2
  • [ 1918-77-0 ]
  • Fmoc-L-Asn-OH [ No CAS ]
  • [ 71989-31-6 ]
  • [ 35737-15-6 ]
  • [ 95753-55-2 ]
  • [ 76-05-1 ]
  • Fmoc-Arg(pg)-OH [ No CAS ]
  • C47H62N16O10S*C2HF3O2 [ No CAS ]
  • 3
  • [ 1918-77-0 ]
  • Fmoc-L-Asn-OH [ No CAS ]
  • [ 71989-31-6 ]
  • [ 35737-15-6 ]
  • [ 96402-49-2 ]
  • [ 76-05-1 ]
  • Fmoc-Arg(pg)-OH [ No CAS ]
  • C51H65N15O8S [ No CAS ]
  • 4
  • [ 1918-77-0 ]
  • [ 13671-00-6 ]
  • 1-(2,6-difluorophenyl)-2-(thiophen-2-yl)ethan-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
10.35 g Reference Example 1 Synthesis of 1-(2,6-difluorophenyl)-2-(thiophen-2-yl)ethan-1-one To 100 ml of a THF solution containing 10.00 g of 2-(thiophen-2-yl)acetic acid was added dropwise 118.5 ml of a 1.9 mol/L THF solution of hexamethyldisilazane sodium at -78 C. and the mixture was stirred for 1 hour. Then, 20 ml of a THF solution containing 12.11 g of <strong>[13671-00-6]methyl 2,6-difluorobenzoate</strong> was added dropwise thereto, then, the temperature of the mixture was raised from -78 C. to room temperature and stirred for 2.5 hours. To the mixture was added an aqueous saturated ammonium chloride solution followed by stirring for 1 hour. Thereafter, ethyl acetate were added and the liquids were separated. The obtained organic layer was washed with saturated brine, and dried over magnesium sulfate. After the solvent was distilled off under reduced pressure, the obtained residue was purified by silica gel column chromatography. The title compound was obtained as 10.35 g of a red oily product. 1H-NMR (CDCl3) delta: 7.39 (1H, m), 7.22 (1H, m), 6.95 (4H, m), 4.36 (1H, s).
 

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