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Chemical Structure| 103-74-2 Chemical Structure| 103-74-2
Chemical Structure| 103-74-2

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Product Citations

Product Citations

Connor Q. Kabes ; Bailey L. Jameson ; John A. Gladysz ;

Abstract: Enantioselective additions of malonate esters to nitroalkenes can be catalyzed by a variety of salts of chiral cobalt(III) trications [Co(1,2-diamine)3]3+ in the presence of nitrogen donor bases in acetone. Catalysts that feature enantiopure 1,2-diphenylethylenediamine are particularly effective, and the base can also be incorporated into one of the counter anions, for example a (substituted) nicotinate. This study shows that such additions can be carried out under solvent free conditions and with reduced reaction times using ball milling, further enhancing the “green” credentials of this large family of earth-abundant-metal catalysts. The effect of various reaction variables are probed (base, counter anions, loading, time, quantity of balls, etc.), and the optimized conditions applied to twelve nitroalkenes, affording products in average yields and ee values of 89% and 74%. The enantioselectivities appear slightly lower than for analogous reactions in solution (0 °C), and possible factors and remedies are discussed.

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Product Details of 2-Pyridineethanol

CAS No. :103-74-2
Formula : C7H9NO
M.W : 123.15
SMILES Code : OCCC1=NC=CC=C1
MDL No. :MFCD00006364
InChI Key :BXGYBSJAZFGIPX-UHFFFAOYSA-N
Pubchem ID :7675

Safety of 2-Pyridineethanol

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335-H412
Precautionary Statements:P261-P273-P305+P351+P338

Application In Synthesis of 2-Pyridineethanol

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 103-74-2 ]
  • Downstream synthetic route of [ 103-74-2 ]

[ 103-74-2 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 103-74-2 ]
  • [ 5579-84-0 ]
References: [1] Patent: CN107827813, 2018, A, .
 

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