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Chemical Structure| 88-14-2 Chemical Structure| 88-14-2
Chemical Structure| 88-14-2

2-Furoic acid

CAS No.: 88-14-2

Furan-2-carboxylic acid, a natural product isolated and purified from the herbs of Hexagonia speciosa with anti-bacterial effect, is also an orally active selective human cathepsin K inhibitor which may have the therapeutic potential for the treatment of diseases characterized by excessive bone loss including osteoporosis.

Synonyms: Furan-2-carboxylic acid; Pyromucic acid; Kyselina 2-furoova

4.5 *For Research Use Only !

95%99%
Cat. No.: A117549 Purity: 95%

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Product Citations

Product Citations

Xue, Qiang ; Li, Hanxi ; Jin, Peng ; Zhou, Xukai ; Wang, Feng ;

Abstract: Traditional H2O2 photocatalysis primarily depends on photoexcited electrons and holes to drive oxygen reduction and water oxidation, respectively. However, singlet oxygen (1O2), often underappreciated, plays a pivotal role in H2O2 production. Meanwhile, photocatalytic biomass conversion has attracted attention, yet studies combining H2O2 synthesis with biomass valorization remain rare and typically yield low-value products. Herein, we report a strategy of photocatalytic valorization of furfuryl alcohol (FFA) coupled with the efficient co-production of H2O2, enabled by covalent organic frameworks (COFs) induced, 1O2-participated Achmatowicz rearrangement. This study introduces polyimide-based COF-N0-3 with tailored nitrogen content, representing an unprecedently efficient platform for 1O2 production. Remarkably, reducing the nitrogen content of the COF enhances 1O2 production, significantly boosting the H2O2 generation rate. In FFA, the primary pathway for H2O2 production is Achmatowicz rearrangement, achieving a rate ten times higher than that reliant on oxygen reduction reaction in pure water, reaching 4549 μmol g -1 h -1. Mechanism studies revealed 1O2 selectively engaged FFA, bypassing hole oxidation to trigger the Achmatowicz rearrangement, producing valuable 6-hydroxy-(2H)-pyranone with 99% conversion and 92% selectivity. This work establishes a coupling strategy for simultaneoues synthesis of H2O2 and biochemicals, offering a transformative approach to sustainable photocatalysis.

Keywords: covalent organic frameworks ; hydrogen peroxide photosynthesis ; biomass valorization coupling ; singlet oxygen

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Product Details of 2-Furoic acid

CAS No. :88-14-2
Formula : C5H4O3
M.W : 112.08
SMILES Code : O=C(C1=CC=CO1)O
Synonyms :
Furan-2-carboxylic acid; Pyromucic acid; Kyselina 2-furoova
MDL No. :MFCD00003238
InChI Key :SMNDYUVBFMFKNZ-UHFFFAOYSA-N
Pubchem ID :6919

Safety of 2-Furoic acid

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of 2-Furoic acid

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Upstream synthesis route of [ 88-14-2 ]
  • Downstream synthetic route of [ 88-14-2 ]

[ 88-14-2 ] Synthesis Path-Upstream   1~1

  • 1
  • [ 2434-03-9 ]
  • [ 88-14-2 ]
  • [ 3439-02-9 ]
References: [1] Patent: US2005/54627, 2005, A1, . Location in patent: Page/Page column 43.
[2] Patent: US2005/54626, 2005, A1, . Location in patent: Page/Page column 42.
 

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