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Chemical Structure| 1996-41-4 Chemical Structure| 1996-41-4

Structure of 1996-41-4

Chemical Structure| 1996-41-4

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Product Details of [ 1996-41-4 ]

CAS No. :1996-41-4
Formula : C6H4ClFO
M.W : 146.55
SMILES Code : C1=C(C(=CC=C1F)O)Cl
MDL No. :MFCD00002168
InChI Key :IGYXYGDEYHNFFT-UHFFFAOYSA-N
Pubchem ID :74814

Safety of [ 1996-41-4 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 1996-41-4 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1996-41-4 ]

[ 1996-41-4 ] Synthesis Path-Downstream   1~3

  • 1
  • [ 1996-41-4 ]
  • [ 79-22-1 ]
  • [ 85953-29-3 ]
YieldReaction ConditionsOperation in experiment
In water; EXAMPLE 3 Production of the nitrophenol (V) 2-Chloro-4-fluorophenol (83.4 g) was added to a solution of sodum hydroxide (27.7 g) in water (450 ml), and methyl chloroformate (69.2 g) was dropwise added thereto at a temperature below 10 C. Precipitated crystals were collected by filtration and washed with water to give methyl(2-chloro-4-fluorophenyl)formate (134.8 g). M.P., 69-71 C.
With sodium hydroxide; In water; EXAMPLE 7 Production of the nitrophenol (VII: X=Cl): 2-Chloro-4-fluorophenol (83.4 g) was added to a solution of sodium hydroxide (27.7 g) in water (450 ml), and methyl chloroformate (69.2 g) was dropwise added thereto at a temperature of below 10 C. Precipitated crystals were collected by filtration and washed with water to give methyl (2-chloro-4-fluorophenyl)formate (134.8 g). M.P., 69-71 C.
With sodium hydroxide; In water; EXAMPLE 10 Production of the nitrophenol (V: X=Cl): 2-Chloro-4-fluorophenol (83.4 g) was added to a solution of sodium hydroxide (27.7 g) in water (450 ml), and methyl chloroformate (69.2 g) was dropwise added thereto at a temperature of below 10 C. Precipitated crystals were collected by filtration and washed with water to give methyl (2-chloro-4-fluorophenyl)formate (134.8 g). M.P., 69-71 C.
With sodium hydroxide; In water; EXAMPLE 10 2-Chloro-4-fluorophenol (83.4 g) was added to a solution of sodium hydroxide (27.7 g) in water (450 ml), and methyl chloroformate (69.2 g) was dropwise added thereto at a temperature below 10 C. Precipitated crystals were collected by filtration and washed with water to give methyl (2-chloro-4-fluorophenyl)formate (134.8 g). M.P., 69-71 C.
With sodium hydroxide; In water; EXAMPLE 12 2-Chloro-4-fluorophenol (83.4 g) was added to a solution of sodium hydroxide (27.7 g) in water (450 ml), and methyl chloroformate (69.2 g) was dropwise added thereto at a temperature below 10 C. Precipitated crystals were collected by filtration and washed with water to give methyl (2-chloro-4-fluorophenyl) formate (134.8 g). M.P., 69-71 C.

 

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