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Chemical Structure| 19455-20-0 Chemical Structure| 19455-20-0

Structure of 19455-20-0

Chemical Structure| 19455-20-0

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Product Details of [ 19455-20-0 ]

CAS No. :19455-20-0
Formula : C4H7KO2
M.W : 126.20
SMILES Code : CC(C)C([O-])=O.[K+]
MDL No. :MFCD00058992
InChI Key :LBOHISOWGKIIKX-UHFFFAOYSA-M
Pubchem ID :23677462

Safety of [ 19455-20-0 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H302-H315-H319-H335
Precautionary Statements:P261-P305+P351+P338

Application In Synthesis of [ 19455-20-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 19455-20-0 ]

[ 19455-20-0 ] Synthesis Path-Downstream   1~27

  • 2
  • [ 19455-20-0 ]
  • [ 39074-38-9 ]
  • [ 40151-61-9 ]
  • 3
  • [ 19455-20-0 ]
  • [ 39074-64-1 ]
  • [ 40151-70-0 ]
  • 4
  • [ 19455-20-0 ]
  • Methanesulfonic acid (2S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3,4-dimethyl-5-oxo-tetrahydro-furan-2-yl ester [ No CAS ]
  • Isobutyric acid (2R,3R,4R)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3,4-dimethyl-5-oxo-tetrahydro-furan-2-yl ester [ No CAS ]
  • Isobutyric acid (2S,3R,4R)-4-(tert-butyl-dimethyl-silanyloxymethyl)-3,4-dimethyl-5-oxo-tetrahydro-furan-2-yl ester [ No CAS ]
  • 6
  • [ 144758-73-6 ]
  • [ 19455-20-0 ]
  • [ 623-05-2 ]
  • C14H18O7P(1-)*K(1+) [ No CAS ]
  • 7
  • [ 144965-58-2 ]
  • [ 19455-20-0 ]
  • [ 623-05-2 ]
  • [ 144965-64-0 ]
  • 8
  • potassium 1-methylethanecarboselenoate [ No CAS ]
  • [ 19455-20-0 ]
  • 9
  • [ 19455-20-0 ]
  • [ 550-44-7 ]
  • [ 32360-86-4 ]
  • 11
  • [ 19455-20-0 ]
  • [ 6789-51-1 ]
  • 5-hydroxy-5-isopropyl-6-methyl-5,6-dihydropyrrolo[3,4-b]pyridine-7-one [ No CAS ]
  • 7-hydroxy-7-isopropyl-6-methyl-6,7-dihydropyrrolo[3,4-b]pyridine-5-one [ No CAS ]
  • 12
  • [ 19455-20-0 ]
  • 2-bromo-1-cyclohexyl-2-(3-fluoro-phenyl)-ethanone [ No CAS ]
  • isobutyric acid 2-cyclohexyl-1-(3-fluoro-phenyl)-2-oxo-ethyl ester [ No CAS ]
  • 13
  • [ 19455-20-0 ]
  • [ 40222-71-7 ]
  • [ 107-21-1 ]
  • [ 7440-66-6 ]
  • [ 21035-72-3 ]
YieldReaction ConditionsOperation in experiment
91% With hydrogen sulfide; EXAMPLE 16 After heating to 90 C. a mixture of 32.24 g of cis-1,3-dibenzylhexahydrofuro[3,4-d]imidazole-2,4-dione, 7.75 g of <strong>[19455-20-0]potassium isobutyrate</strong>, 2.08 g of sulfur and 47.56 g of polyethylene glycol (the average molecular weight: 600), the mixture was stirred for 4.5 hours at the temperature while blowing 3.75 g of hydrogen sulfide at a rate of 10 ml/minute. Then blowing of hydrogen sulfide was stopped and the resultant mixture was stirred for 3.5 hours at the temperature. Thereafter, the resulting mixture was subjected to reduction reaction with zinc powder and after-treatment as described in Example 1, obtained oil layer was subjected to LC analysis. The net yield of cis-1,3-dibenzylhexahydrothieno[3,4-d]imidazole-2,4-dione was 30.93 g (yield percentage: 91%).
  • 14
  • [ 19455-20-0 ]
  • α-Ethoxy-ω-hydroxy-poly (1,3-dioxolane) [ No CAS ]
  • [ 105-36-2 ]
  • α-ethoxy-ω-carboxymethyl-poly(1,3-dioxolane) [ No CAS ]
YieldReaction ConditionsOperation in experiment
With sodium chloride; In sodium hydroxide; cyclohexane; toluene; C. Succinimidyl α-Ethoxy-ω-carboxymethyl-poly (1;3-dioxolane) α-Ethoxy-ω-hydroxy-poly(1,3-dioxolane) (5 g, 0.09 mmole) was dissolved in anhydrous toluene (20 mL) and potassium t-butanoate (1.6 g, 14 mmole) was added. The solution was brought to reflux, then kept at 50 C. for 5 h. Ethyl bromoacetate (1.6 mL, 14 mmole) was slowly added and the solution was stirred overnight at the same temperature. The precipitated salts were removed by filtration and washed with methylene chloride (20 mL). The polymer was recovered by partially concentrating the filtrate and slowly pouring into ether/cyclohexane (1:1, 200 mL). The polymer was dried in vacuo, then dissolved in 1N NaOH (20 mL) and NaCl (4 g) was added. After 1 hour, this solution was acidified with 2N HCl to pH 3.0 and extracted with dichloromethane (3*50 mL). The combined organic phase was dried (MgSO4), concentrated to 30 mL, and poured into cool ether/cyclohexane (3:1, 300 mL). The precipitate was collected by filtration and dried in vacuo. The resulting α-ethoxy-ω-carboxymethyl-poly(1,3-dioxolane), (5 g, 0.09 mmole) was dissolved in anhydrous dichloromethane (20 mL), and N-hydroxysuccinimide (0.23 g, 2.0 mmole) and dicyclohexylcarbodiimide (0. 413 g, 2.00 mmole) were added.
  • 15
  • [ 79-31-2 ]
  • [ 19455-20-0 ]
YieldReaction ConditionsOperation in experiment
With potassium hydroxide; In ethanol; E. Potassium 2-methylpropanoate A mixture of 8.8 g of 2-methylpropanoic acid and 5.6 g of potassium hydroxide in 25 ml of ethanol was allowed to react for 45 minutes. The solution was diluted to a final volume of 500 ml with diethyl ether. The precipitated salt was collected and dried to yield 9.4 g of potassium-2-methylpropanoate.
  • 16
  • [ 19455-20-0 ]
  • N'-(4-cyano-3-isopropyl-5-isothiazolyl)-N,N-dimethylchloroformamidine [ No CAS ]
  • [ 63940-90-9 ]
YieldReaction ConditionsOperation in experiment
In acetonitrile; F. N'-(4-Cyano-3-isopropyl-5-isothiazolyl)-N,N-dimethyl-N'-(2-methylpropanoyl)urea A mixture of 5 g N'-(4-cyano-3-isopropyl-5-isothiazolyl)-N,N-dimethylchloroformamidine (from part D), 4.8 g of potassium 2-methylpropanate (from part E), 20 ml of dry acetonitrile and a catalytic amount of 2,3,11,12-dibenzo-1,4,7,10,13,16-hexaoxacycloctadeca-2,11-diene (dibenzo-18-crown-6) was allowed to react during 24 hours. The inorganic salts were removed by filtration. The volatile materials were evaporated under reduced pressure. The residue was recrystallized from 150 ml of 70:30 hexane:benzene to yield 3.3 g of N'-(4-cyano-3-isopropyl-5-isothiazolyl)-N,N-dimethyl-N'-(2-methylpropanoyl)urea, mp 127-129. The ir and nmr spectra were consistent with the assigned structure. The structure assignment was confirmed by the uv spectrum. Analysis: Calc'd for C14 H20 N4 O2 S: C, 54.52; H, 6.59; N, 18.17; S, 10.40; Found: C, 54.81; H, 6.69; N, 17.93; S, 10.10.
  • 17
  • [ 19455-20-0 ]
  • [ 74-97-5 ]
  • [ 61644-18-6 ]
YieldReaction ConditionsOperation in experiment
39% In N,N-dimethyl-formamide; Example 8 (Isobutyryloxymethyl) To a stirred mixture of DMF (12 g: 3.1 parts by weight) and <strong>[19455-20-0]potassium isobutyrate</strong> (3.85 g: 30 millimole) is added bromochloromethane (78 g: 20 equivalents) and the mixture is kept at room temperature for 60 hours and at 50C for 8 hours. The reaction mixture is washed with water, dried, and distilled at atmospheric pressure to collect the part boiling at 135 to 140C to give chloromethyl 2-methylpropionate (1.4 g: Yield 39 %). NMR (CDCl3): 1.23 (s, 9H), 1.78 (d, J=7Hz, 3H), 6.53 (q, J=7Hz, 1H).
  • 18
  • [ 19455-20-0 ]
  • silver nitrate [ No CAS ]
  • [ 24418-71-1 ]
  • 19
  • [ 19455-20-0 ]
  • cis-diaquabis(ethane-1,2-diamine)cobalt(III) perchlorate [ No CAS ]
  • cis-{Co(iso-C3H7CO2)2en2}ClO4 [ No CAS ]
  • 20
  • [ 19455-20-0 ]
  • chromium(III) nitrate nonahydrate [ No CAS ]
  • [ 7732-18-5 ]
  • Cr3O(7+)*6(OOCCH(CH3)2)(1-)*3H2O*NO3(1-)=(Cr3O(O2CCH(CH3)2)6(H2O)3)(NO3) [ No CAS ]
  • 21
  • [ 19455-20-0 ]
  • 1-((2R,3R,3aR,9aR)-3-Chloromethoxy-5,5,7,7-tetraisopropyl-tetrahydro-1,4,6,8-tetraoxa-5,7-disila-cyclopentacycloocten-2-yl)-1H-pyrimidine-2,4-dione [ No CAS ]
  • [ 1186207-96-4 ]
  • 22
  • [ 19455-20-0 ]
  • [ 2052-01-9 ]
  • 23
  • 2,2-dimethylmalonate dipotassium [ No CAS ]
  • [ 19455-20-0 ]
  • 24
  • [ 19455-20-0 ]
  • [ 97-97-2 ]
  • [ 791121-01-2 ]
YieldReaction ConditionsOperation in experiment
80% In N,N-dimethyl-formamide; at 150℃; for 15h; The reaction was performed using a solution of chloroacetaldehyde dimethyl acetal (17, 201 mmol, 24.92 g, 22.70 mL) in DMF (300 mL) was added <strong>[19455-20-0]potassium isobutyrate</strong> (16, 110.6 mmol, 13.95 g) and the mixture was refluxed at 150 C for 2 h. Additional16 (110.6 mmol, 13.95 g) was charged to the reactions mixture portion wise while refluxing. The reflux was continued for 13 h and mixture was allowed to room temperature. Water (300 mL) was added, and the resulting mixture was extracted with EtOAc (3 100 mL). The organic phase was dried with sodium sulfate anhydrous and concentrated under reduced pressure where 18 was obtained a 80% yield; IR (KBr, cm 1): 1130, 1195 (CeO), 1739 (CO2), 2974 (CeH sp3); 1H NMR (CDCl3, 200 MHz): d 1.19 (d, 6H, J 6.84 Hz), 2.67 (m, 1H), 3.41 (s, 6H), 4.12 (d, 2H, J 5.22 Hz), 4.54 (m, 1H); 13CNMR (CDCl3, 50 MHz): d 18.7, 34.1, 53.5, 53.7, 62.6, 101.4, 171.8; GC: RT¼ 6.94 min (100%); Mass calculated: 176.1, C8H16O4
  • 25
  • [ 19455-20-0 ]
  • [ 1451396-66-9 ]
  • [ 126544-47-6 ]
YieldReaction ConditionsOperation in experiment
In 1-methyl-pyrrolidin-2-one; at 50℃; for 5h; General procedure: EXAMPLE 7: ISOBUTOXIDE SALT SCREENING 1 g aliquots of industrial grade compound 2 (with an epimer ratio R/S of 97.2:2.8) are dissolved in 5 ml of solvent at ambient temperature, combined with 1 .4 equivalents of isobutoxide salt and stirred at 50 'C. Conversion monitoring using HPLC-UV is carried out after 1 h, 2 h and 5 h. For results: see the Table.
In 1-methyl-pyrrolidin-2-one; at 50℃; for 5h; General procedure: 1 g aliquots of industrial grade compound 2 (with an epimer ratio R/S of 97.2:2.8) are dissolved in 5 ml of solvent at ambient temperature, combined with 1.4 equivalents of isobutoxide salt and stirred at 50 C. Conversion monitoring using HPLC-UV is carried out after 1 h, 2 h and 5 h. For results: see the Table.
  • 26
  • [ 19455-20-0 ]
  • [ 1464066-05-4 ]
  • [ 1373391-44-6 ]
YieldReaction ConditionsOperation in experiment
55% With tetrabutylammomium bromide; In 2-methyltetrahydrofuran; at 70℃; for 20h; General procedure: A mixture of 6 (463 g, 1.0 mol) and compound 12 (3-10 mol,Table 2, entries 10-13) was heated in 2-MeTHF (0.04 molL-1) for 16 h at reflux. The reaction mixture was then cooleddown to r.t. and washed with aq HCl (1 M), followed by aqNa2CO3 (2.5 w/w% solution). The organic layer was thenconcentrated down. Final crystallization from a mixture of 2-MeTHF and diisopropyl ether (1:5) gave 3 in a range of 62-95% yield (Table 2, entries 10-13); mp 148.6 C. 1H NMR(360 MHz, acetone-d6): δ = 0.99-1.10 (m, 3 H), 1.12-1.30(m, 12 H), 2.05-2.13 (m, 3 H), 2.58-2.77 (m, 2 H), 3.23-3.04 (m, 1 H), 4.48 (d, J = 12.09 Hz, 1 H), 4.57 (d, J = 12.10Hz, 1 H), 5.73 (d, J = 8.40 Hz, 1 H), 6.44 (br s, 1 H), 7.74 (d,J = 8.00 Hz, 1 H), 10.22 (br s, 1 H) ppm. 13C NMR (90 MHz,acetone-d6): δ = 11.71, 19.24, 19.34, 34.17, 34.42, 40.31,64.29, 75.73, 96.05, 103.16, 150.68, 163.18, 176.10, 176.66ppm.
  • 27
  • [ 19455-20-0 ]
  • [ 515-40-2 ]
  • C14H20O2 [ No CAS ]
YieldReaction ConditionsOperation in experiment
88% With 1-methyl-pyrrolidin-2-one; at 200℃; General procedure: A solution of 318 g of 1-chloro-2-methyl-2-phenylpropane in 1200 mL of N-methyl-pyrrolidone was added 2.82 mol of potassium salt of aliphatic carboxylic acid and heated the reaction mass at 200 C till completion. Reaction mixture was cooled to room temperature, filtered through hyflow bed and washed with 190 mL of N-methyl pyrrolidone. Filtrate was subjected to distillation at 120-135 C under the vacuum to obtain compound 3.
 

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