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Chemical Structure| 1817-49-8 Chemical Structure| 1817-49-8

Structure of 1817-49-8

Chemical Structure| 1817-49-8

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Product Details of [ 1817-49-8 ]

CAS No. :1817-49-8
Formula : C15H12O
M.W : 208.26
SMILES Code : OC(C#CC1=CC=CC=C1)C2=CC=CC=C2
MDL No. :MFCD06654198

Safety of [ 1817-49-8 ]

GHS Pictogram:
Signal Word:Warning
Hazard Statements:H319
Precautionary Statements:P305+P351+P338

Application In Synthesis of [ 1817-49-8 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

  • Downstream synthetic route of [ 1817-49-8 ]

[ 1817-49-8 ] Synthesis Path-Downstream   1~6

  • 1
  • [ 1817-49-8 ]
  • [ 113-00-8 ]
  • [ 40230-24-8 ]
  • 2
  • [ 1817-49-8 ]
  • [ 1593-60-8 ]
  • [ 1415035-26-5 ]
YieldReaction ConditionsOperation in experiment
38% With iodine; In dichloromethane; water; at 25℃; for 3h; General procedure: To a solution of propargyl alcohol 1 (0.6 mmol) and N-tosyl hydroxylamine 2 (0.5 mmol) in wet DCM (5 mL) was added I2 (1.0 mmol) slowly at 25 C, and the reaction mixture was stirred at a shown temperature for an indicated period of time shown in text. Saturated aqueous Na2S2O3 was added to quench the reaction and the mixture was extracted with DCM. The organic layer was washed with brine and dried over Na2SO4, filtered and concentrated. The residue was purified flash column chromatography on silica gel with DCM/hexane as eluent to give 4 or 5.400.0971.
  • 3
  • [ 1817-49-8 ]
  • [ 14135-38-7 ]
  • 2-[(2-fluorophenyl)thio]-3-phenyl-1H-inden-1-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
61% With dipotassium peroxodisulfate; iodine; dibenzoyl peroxide; In nitromethane; at 120℃; for 24h;Inert atmosphere; 41.6 mg (0.2 mmol) of 1,3-diphenylpropynol, 50.9 mg (0.2 mmol) of bis(2-fluorophenyl)disulfide 14.5 mg (0.06 mmol) of benzoyl peroxide, 101.6 mg (0.4 mmol) of iodine, 108.1 mg (0.4 mmol) of potassium persulfate was added to the reaction tube, 2 mL of nitromethane was added, and the reaction tube was filled with N2. 120 ° C for 24 hours. After the reaction was completed, the reaction mixture was cooled to room temperature, the organic layer was dried over anhydrous MgSO4, filtered and the filtrate was evaporated to dryness. The solvent was removed and the residue was chromatographed on silica gel using a petroleum ether and ethyl acetate volume ratio of 200: 1 mixture of the eluent, the effluent was collected according to the actual gradient, TLC detected, and the product-containing effluent was combined. The solvent was distilled off on a rotary evaporator and dried in vacuo to give 40.6 mg of 2-(2-fluorophenylthio)-3-phenylinden-1-one as a red solid in 61percent yield.
  • 4
  • [ 1817-49-8 ]
  • [ 50405-45-3 ]
  • (Z)-3-benzylidene-6,7-dimethyl-2-phenyl-2,3-dihydro-4H-furo[3,2-c]pyran-4-one [ No CAS ]
YieldReaction ConditionsOperation in experiment
92% With boric acid; palladium diacetate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; In 1,4-dioxane; at 100℃; for 2h;Inert atmosphere; General procedure: Synthesis of 3aa (Table 3, entry 4). A stirred solution of Pd(OAc)2 (5.8mg, 26mumol) and BINAP (32mg, 51mumol) in dioxane (1.0mL) was heated to 100C, and stirring was continued for 5min. After the resulting solution was cooled to rt, propargylic alcohol 1a (54mg, 257mumol), 1,3-cyclohexanedione (2a) (35mg, 308mumol) and boric acid (3.2mg, 51mumol) in dioxane (1.6mL) were added. The reaction mixture was then allowed to heat to 100C, and stirring was continued for 2h. After filtration of the reaction mixture using small amount of silica gel followed by concentration, the residue was chromatographed on silica gel with hexane-AcOEt (80:20 v/v) as eluent to give 3aa (66mg, 84% yield).
  • 5
  • [ 1817-49-8 ]
  • [ 1267217-46-8 ]
  • C23H16F3NO2 [ No CAS ]
  • 6
  • [ 4139-61-1 ]
  • [ 1817-49-8 ]
  • [ 1450853-42-5 ]
 

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