1741-50-0|5-Bromo-2-phenyl-1H-benzo[d]imidazole| Ambeed

CAS No. :	1741-50-0
Formula :	C₁₃H₉BrN₂
M.W :	273.13
SMILES Code :	BrC1=CC2=C(NC(=N2)C2=CC=CC=C2)C=C1
MDL No. :	MFCD09033221
InChI Key :	GVFCYTFUNNARML-UHFFFAOYSA-N
Pubchem ID :	12948775

Safety of [ 1741-50-0 ]

GHS Pictogram:
Signal Word:	Warning
Hazard Statements:	H302-H315-H319-H335
Precautionary Statements:	P261-P305+P351+P338

Application In Synthesis of [ 1741-50-0 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 1741-50-0 ]

[ 1741-50-0 ] Synthesis Path-Downstream 1~34

1
[ 202328-05-0 ]
[ 1741-50-0 ]

References: [1]Chemische Berichte,1877,vol. 10,p. 1710.

2
[ 21719-91-5 ]
[ 1741-50-0 ]

References: [1]Chemistry - A European Journal,2012,vol. 18,p. 13964 - 13967.
[2]Canadian Journal of Chemistry,1982,vol. 60,p. 1122 - 1126.

Yield	Reaction Conditions	Operation in experiment
99%	In 1-methyl-pyrrolidin-2-one; water; at 445℃; under 187519.0 Torr; for 0.00277778h;Supercritical conditions;	General procedure: Under the same conditions as in Example 1-5 except that N-methyl-1,2-phenylenediamine (manufactured by Sigma-Aldrich) and benzoic acid hydride (manufactured by Tokyo Chemical Industry Co., Ltd.) were used at a pressure of 25 MPa, (13) was carried out in supercritical water. As a result, the reaction time was 10 seconds, and the yield was 99%
88%	With acetic acid; at 20℃; for 0.166667h;	General procedure: Add 1 ml of catalytic amount of glacial acetic acid to the mortar.O-phenylenediamine 1 mmol,1.2 mmol of benzaldehyde was rapidly ground at room temperature for 10 minutes.The product was extracted with ethyl acetate and water.Concentrated under reduced pressure,The product was purified by column chromatography to give a white solid.The yield was 93%.
32%	With [4,4′-bis(1,1-dimethylethyl)-2,2′-bipyridine-N1,N1′]bis{3,5-difluoro-2-[5-(trifluoromethyl)-2-pyridinyl-κN]phenyl-κC}iridium(III) hexafluorophosphate; In tert-butyl methyl ether; at 20℃; for 36.0h;Schlenk technique; Sealed tube;	General procedure: In a 25mL Schlenk tube, add 0.2mmol of intermediate 5, 1% of the photocatalyst Ir [dF (CF3) ppy] 2 (dtbbpy) PF6, seal, insert an argon balloon, replace the gas three to four times, and then inject 1mL Methyl tert-butyl ether was placed in a photoreactor and allowed to react at room temperature for 36 hours. After the reaction was completed, 15 mL of ethyl acetate was added to dilute the reaction solution, poured into a separating funnel, 10 mL of saturated sodium carbonate solution was added, extraction was performed, and the liquid phase was extracted with ethyl acetate (20 mL × 2). The organic layers were combined, It was washed with saturated sodium chloride, dried over anhydrous sodium sulfate, and dissolved under reduced pressure. The crude product was separated by column chromatography to obtain 16 mg of the target product I, a white solid, a yield of 40%, and a melting point of 297-298 C. 1H NMR (400MHz, DMSO-d6) δ 12.97 (s, 1H), 9.34 (d, J = 1.8Hz, 1H), 8.45 (d, J = 1.8Hz, 1H), 7.66 (d, J = 7.2Hz 1H), 7.52 (d, J = 7.2Hz, 1H), 7.27-7.16 (m, 2H). 13C NMR (100MHz, DMSO-d6) δ 156.1, 147.6, 147.5, 144.2, 134.8, 123.1, 122.2, 119.9, 119.2, 112.2. HR-MS (ESI): Calcd for C10H8N3S [M + H] +202.0433, found 202.0434.

4
[ 7647-01-0 ]
[ 202328-05-0 ]
Sn [ No CAS ]
[ 1741-50-0 ]

References: [1]Chemische Berichte,1877,vol. 10,p. 1710.

5
[ 100-52-7 ]
[ 1575-37-7 ]
[ 1741-50-0 ]

Yield	Reaction Conditions	Operation in experiment
78%	In 1,4-dioxane; at 100℃;	Add S1 (1 mmol),Benzaldehyde (1mmol), 8ml 1,4-dioxane, heat to 100C,After the reaction was completed, the solvent was distilled off under reduced pressure,The crude product was purified by column chromatography (dichloromethane/n-hexane/methanol (volume ratio 20:10:1)) to obtain Intermediate 1-1 (yield 78%).
70%	With H2SO4 in hydrothermal carbon(II); In ethanol; at 80℃; for 1.5h;	General procedure: In an oven-dried 25mL round-bottomed flask equipped with a magnetic stir bar,o-phenylenediamine (1 mmol), benzaldehyde (1 mmol) and 100 mg of H2SO4HTC (II) were mixed and diluted with 5ml of ethanol. The mixture was stirred at reflux for1.5 hr. At the end of the reaction, the catalyst was recovered by filtration and the filtratewas extracted with ethyl acetate (310 mL). The combined organic layers were washedwith 10 ml of water, dried over anhydrous Na2SO4 and filtered. The solvent was evaporated.Pure product was obtained using flash chromatography on silica gel using 20%ethyl acetate in hexane.
		To a mixture of 4-bromobenzene-1,2-diamine (0.2 g) in DMF/water (2 mL/50 μL) was added oxone (0.4 g) and benzaldehyde (0.12 g) in DMF (2 mL). After 1 hour, the mixture was diluted with water, treated with K2CO3 and filtered. The filtrate was dissolved in dichloromethane, and this mixture was dried (Na2SO4), filtered and concentrated. The concentrate was chromatographed on silica with an Intelliflash-280 purification system with ethyl acetate/hexanes.

References: [1]Catalysis science and technology,2020,vol. 10,p. 5171 - 5180.
[2]Green Chemistry,2014,vol. 16,p. 3160 - 3168.
[3]Chemistry - A European Journal,2018,vol. 24,p. 3481 - 3487.
[4]Tetrahedron Letters,2005,vol. 46,p. 4315 - 4319.
[5]Patent: CN112979616,2021,A .Location in patent: Paragraph 0131-0135.
[6]Organic Preparations and Procedures International,2021,vol. 53,p. 268 - 277.
[7]Patent: US2007/203143,2007,A1 .Location in patent: Page/Page column 41.

6
[ 728-90-5 ]
[ 1741-50-0 ]

References: [1]Chemische Berichte,1877,vol. 10,p. 1710.

7
[ 1741-50-0 ]
[ 73183-34-3 ]
[ 1257250-52-4 ]

Yield	Reaction Conditions	Operation in experiment
	With potassium acetate;dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH2Cl2; In N,N-dimethyl-formamide; at 160 - 180℃; for 0.583333h;microwave irradiation;	A mixture of EXAMPLE 1A (0.095 g), bis(pinacolato)diboron (0.17 g), potassium acetate (0.10 g) and dichloro(1,1'-bis(diphenylphosphino)ferrocene)-palladium(II).dichloromethane (0.007 g) in DMF (2.5 mL) was stirred at 160 C. for 15 minutes in a microwave reactor. Fresh bis(pinacolato)diboron (2 equivalents), potassium acetate (3 equivalents), and dichloro(1,1'-bis(diphenylphosphino)ferrocene) palladium(II).dichloromethane (0.03 equivalents) were added, and the mixture was stirred at 180 C. for another 20 minutes, cooled, filtered through diatomaceous earth (Celite) and concentrated. The concentrate was purified on silica gel with an Intelliflash-280 purification system with ethyl acetate/hexanes. To the product was added cis-4-(4-(4-amino-3-iodopyrazolo[3,4-d]pyrimidin-1-yl)cyclohexyl)-1-methylpiperazin-2-one, prepared as described in WO 05/074603, (0.11 g), 2M Na2CO3 (0.23 mL) and dichlorobis(triphenyl-phosphine)palladium(II) (8 mg) in ethanol/water (2 mL/1 mL). The mixture was stirred at 120 C. for 20 minutes in a microwave reactor, cooled, filtered through diatomaceous earth (Celite) and dried (Na2SO4) filtered and concentrated. The concentrate was purified by reverse phase HPLC with CH3CN/water/0.1% TFA. 1H NMR (300 MHz, DMSO-d6) δ 13.09 (d, 1H), 8.25-8.20 (m, 3H), 7.89-7.68 (m, 2H), 7.61-7.50 (m, 4H), 4.88-4.78 (m, 1H), 3.07 (bs, 2H), 2.83 (s, 3H), 2.74-2.71 (m, 2H), 2.36-2.22 (m, 3H), 2.16-2.04 (m, 2H), 1.76-1.60 (m, 4H).

References: [1]Patent: US2007/203143,2007,A1 .Location in patent: Page/Page column 41.

8
[ 875-51-4 ]
[ 707-07-3 ]
[ 1741-50-0 ]
[ 716-79-0 ]

Yield	Reaction Conditions	Operation in experiment
80%	With indium; acetic acid; In ethyl acetate; for 1.5h;Reflux; Inert atmosphere;	General procedure: 2-Nitroaniline derivative (1 mmol) was added to a mixture of indium powder (574 mg, 5.0 mmol for 2-nitroaniline, 918 mg 8.0 mmol for 1,2-dinitroarene), and acetic acid (0.572 mL, 10 mmol) in ethyl acetate (2 mL), followed by the addition of trimethyl orthoester (2.0 mmol) in ethyl acetate (3 mL for 2-nitroaniline; 8 mL for 1,2-dinitroarene). The reaction mixture was stirred at reflux under a nitrogen atmosphere. After the reaction was completed, the reaction mixture was diluted with ethyl acetate (30 mL), filtered through Celite, poured into 10% NaHCO3 (30 mL), and then extracted with ethyl acetate (30 mL×3). The combined organic extracts were dried over MgSO4, filtered, and concentrated. The residue was eluted with ethyl acetate/hexane (v/v=10/90) for 2-phenylbenzimidazole derivatives or methanol/dichloromethane (v/v=1/99) for 2-methylbenzimidazole derivatives through a silica gel column to give the corresponding benzimidazoles. The structures of the benzimidazoles were characterized by 1H NMR, 13C NMR, FTIR, and GC-MS, and were mostly known compounds. HRMS data were reported in addition for unknown compounds.

References: [1]Tetrahedron,2011,vol. 67,p. 8027 - 8033.

9
[ 100-47-0 ]
[ 106-40-1 ]
[ 1741-50-0 ]

References: [1]Chemistry - A European Journal,2012,vol. 18,p. 13964 - 13967.

10
[ 1418298-88-0 ]
[ 1741-50-0 ]

References: [1]Molecules,2012,vol. 17,p. 12506 - 12520.

11
[ 1242182-79-1 ]
[ 1741-50-0 ]

References: [1]Chemical Communications,2013,vol. 49,p. 7352 - 7354.

12
[ 100-47-0 ]
[ 591-19-5 ]
[ 1741-50-0 ]

References: [1]Chemical Communications,2013,vol. 49,p. 7352 - 7354.

13
[ 66416-72-6 ]
[ 100-47-0 ]
[ 1741-50-0 ]

References: [1]Organic and Biomolecular Chemistry,2013,vol. 11,p. 7271 - 7275.

14
[ 1741-50-0 ]
[ 832114-00-8 ]
[ 1613695-61-6 ]

References: [1]Journal of the American Chemical Society,2014,vol. 136,p. 9308 - 9319.

15
[ 875-51-4 ]
[ 100-51-6 ]
[ 1741-50-0 ]

Yield	Reaction Conditions	Operation in experiment
81%	With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In toluene; at 160℃; for 24.0h;Schlenk technique; Inert atmosphere; Sealed tube;	General procedure: GeneralProcedure for the preparation of 2-Phenyl-1H-benzoimidazole (3aa): A 25mL over-dried Schlenk tube was charged with 2-nitroaniline (41.4 mg, 0.3 mmol),benzyl alcohol (97.2 mg, 0.90 mmol) and Pd(dppf)Cl2 (12.2 mg, 0.015mmol). The tube was purged with nitrogen three times. Toluene (1 mL) was addedto the sealed reaction vessel by syringe. The reaction mixture was stirred in apreheated oil bath at 160 oC for 24 h. After cooling to roomtemperature, the reaction mixture was then concentrated in vacuo, and theresidue was purified by column chromatography (silica gel, petroleumether/ ethyl acetate = 4:1) to give 3aa as a pale yellow solid (56.5 mg, 97%).
73%	With sodium sulfide hydrate; iron(III) chloride hexahydrate; at 140℃; for 24.0h;Inert atmosphere;	General procedure: A 20-mL test-tube equipped with a magnetic stirring bar was charged with o-nitroaniline 1 (2.5 mmol, 1 equiv), alcohol 2 or 5 (3 mmol, 1.2equiv), Na2S·nH2O (≥60%, 130 mg, 1 mmol, 40 mol%) and FeCl3·6H2O(7 mg, 0.025 mmol, 1 mol%). The resulting mixture was stirred for 24h under an argon atmosphere at the indicated temperature (see Schemes 2 and 3 and Table 2). After cooling to r.t., the mixture was purified in different ways. (i) For NH benzimidazole products, the mixture was washed with CH2Cl2 (3 × 2 mL) then dissolved in MeOH.The MeOH solution was filtered through a short pad of silica gel. The filtrate was concentrated in vacuo to afford the NH benzimidazole product. Further purification by column or recrystallization was carried out if necessary. (ii) For N-methyl-2-phenylbenzimidazole 3ha and quinoxalines 5, the crude mixture was dissolved in a minimum volume of CH2Cl2 and purified by column chromatography (silica gel or alumina, heptane-EtOAc, EtOAc, EtOAc-MeOH, hexane-Et2O). We noted that some 13C NMR signals of NH-benzimidazoles are missing or difficult to observe.
73%	With 1,1'-bis-(diphenylphosphino)ferrocene; In toluene; at 150℃; for 24.0h;Inert atmosphere; Sealed tube;	General procedure: The preparation of 2-phenyl-1H-benzoimidazole (3a): A 15 mL capped tube was charged with 2-nitroaniline (0.36 mmol), benzyl alcohol (0.094 mL, 0.90 mmol) and dppf (0.018 mmol). The tube was flushed with argon for 10 min. Then the degassed toluene (3 mL) was added. The tube was flushed with argon, capped, and heated at 150 C for 24 h. After cooling to room temperature, the reaction mixture was then concentrated in vacuo, and the residue was purified by column chromatography (silica gel, petroleum ether/ethyl acetate = 4:1) to afford the pure 3a as a white solid. The product was identified by NMR and MS and the data are identical to the reported values.

References: [1]Tetrahedron Letters,2016,vol. 57,p. 4645 - 4649.
[2]Synthesis,2015,vol. 47,p. 1741 - 1748.
[3]Tetrahedron Letters,2013,vol. 54,p. 6934 - 6936.

16
[ 100-46-9 ]
[ 1575-37-7 ]
[ 1741-50-0 ]

References: [1]Organic Letters,2017,vol. 19,p. 5629 - 5632.
[2]Green Chemistry,2021,vol. 23,p. 9439 - 9446.
[3]European Journal of Organic Chemistry,2016,vol. 2016,p. 1025 - 1032.

17
[ 1575-37-7 ]
[ 100-51-6 ]
[ 1741-50-0 ]

References: [1]Chemistry - A European Journal,2016,vol. 22,p. 5425 - 5429.
[2]Applied Organometallic Chemistry,2022.

18
[ 93-97-0 ]
[ 1575-37-7 ]
[ 1741-50-0 ]

References: [1]Green Chemistry,2016,vol. 18,p. 3494 - 3498.

19
[ 611-73-4 ]
[ 1575-37-7 ]
[ 1741-50-0 ]

References: [1]Advanced Synthesis and Catalysis,2016,vol. 358,p. 1975 - 1981.

20
[ 1741-50-0 ]
[ 501-65-5 ]
10-bromo-5,6-diphenylbenzo[4,5]imidazo[2,1-a]isoquinoline [ No CAS ]

References: [1]European Journal of Organic Chemistry,2018,vol. 2018,p. 5512 - 5519.

21
[ 615-57-6 ]
[ 100-52-7 ]
[ 1741-50-0 ]

Yield	Reaction Conditions	Operation in experiment
76%	With ammonium hydroxide; 8-quinolinol; caesium carbonate; nickel dichloride; at 100℃; for 0.216667h;Sealed tube; Microwave irradiation;	General procedure: A 10 mL glass tube was charged with the appropriate 2-haloaniline(0.5 mmol), 25-28% aq NH3 (2 mL), the appropriate aldehyde(0.6 mmol), NiCl2 (11.88 mg, 0.05 mmol), quinolin-8-ol(7.258 mg, 0.05 mmol), and Cs2CO3 (325.82 mg, 1.0 mmol). Thevessel was then sealed with a septum and placed in the cavity ofa Discover microwave synthesizer (CEM Corp., Buckingham,UK), and irradiated at 130 W. The temperature was rampedfrom r.t. to the desired temperature of 100 C, then held at thistemperature for 13 min. The mixture was stirred continuouslyduring the reaction. The mixture was then allowed to cool to r.t.and the solvent was removed under reduced pressure. Theresidue was purified by column chromatography (silica gel) toafford the corresponding product. The structures of the productswere confirmed by NMR and MS spectroscopic analyses.2-Phenyl-1H-benzo[d]imidazole (2a)Light-yellow solid; yield: 89.24 mg (92%).

References: [1]Synlett,2018,vol. 29,p. 2722 - 2726.
[2]Organic and Biomolecular Chemistry,2018,vol. 16,p. 8090 - 8094.

22
[ 66416-72-6 ]
[ 100-52-7 ]
[ 1741-50-0 ]

Yield	Reaction Conditions	Operation in experiment
84%	With ammonium hydroxide; 8-quinolinol; caesium carbonate; nickel dichloride; at 100℃; for 0.216667h;Sealed tube; Microwave irradiation;	General procedure: A 10 mL glass tube was charged with the appropriate 2-haloaniline(0.5 mmol), 25-28% aq NH3 (2 mL), the appropriate aldehyde(0.6 mmol), NiCl2 (11.88 mg, 0.05 mmol), quinolin-8-ol(7.258 mg, 0.05 mmol), and Cs2CO3 (325.82 mg, 1.0 mmol). Thevessel was then sealed with a septum and placed in the cavity ofa Discover microwave synthesizer (CEM Corp., Buckingham,UK), and irradiated at 130 W. The temperature was rampedfrom r.t. to the desired temperature of 100 C, then held at thistemperature for 13 min. The mixture was stirred continuouslyduring the reaction. The mixture was then allowed to cool to r.t.and the solvent was removed under reduced pressure. Theresidue was purified by column chromatography (silica gel) toafford the corresponding product. The structures of the productswere confirmed by NMR and MS spectroscopic analyses.2-Phenyl-1H-benzo[d]imidazole (2a)Light-yellow solid; yield: 89.24 mg (92%).

References: [1]Synlett,2018,vol. 29,p. 2722 - 2726.
[2]Organic and Biomolecular Chemistry,2018,vol. 16,p. 8090 - 8094.

23
[ 1741-50-0 ]
[ 100-42-5 ]
5-bromo-2-(2-styrylphenyl)-1H-benzo[d]imidazole [ No CAS ]

References: [1]Advanced Synthesis and Catalysis,2019,vol. 361,p. 535 - 541.

24
[ 1741-50-0 ]
[ 100-42-5 ]
9-bromo-6-phenyl-5,6-dihydrobenzo[4,5]imidazo[2,1-a]isoquinoline [ No CAS ]
10-bromo-6-phenyl-5,6-dihydrobenzo[4,5]imidazo[2,1-a]isoquinoline [ No CAS ]
9-bromo-6-phenyl-1-styryl-5,6-dihydrobenzo[4,5]imidazo[2,1-a]isoquinoline [ No CAS ]
10-bromo-6-phenyl-1-styryl-5,6-dihydrobenzo[4,5]imidazo[2,1-a]isoquinoline [ No CAS ]

References: [1]Advanced Synthesis and Catalysis,2019,vol. 361,p. 535 - 541.

25
[ 698-16-8 ]
[ 1741-50-0 ]

References: [1]Journal of Organic Chemistry,2019,vol. 84,p. 8646 - 8660.

26
[ 106-40-1 ]
[ 1741-50-0 ]

References: [1]Journal of Organic Chemistry,2019,vol. 84,p. 8646 - 8660.

27
(E)-N-(4-bromophenyl)-N′-hydroxybenzimidamide [ No CAS ]
[ 1741-50-0 ]

References: [1]Journal of Organic Chemistry,2019,vol. 84,p. 8646 - 8660.

28
(E)-N-(4-bromophenyl)-N′-((4-(trifluoromethyl)benzoyl)oxy)benzimidamide [ No CAS ]
[ 1741-50-0 ]

References: [1]Journal of Organic Chemistry,2019,vol. 84,p. 8646 - 8660.

29
[ 721-04-0 ]
[ 1575-37-7 ]
[ 1741-50-0 ]
[ 4887-88-1 ]
[ 108-95-2 ]

Yield	Reaction Conditions	Operation in experiment
	With 2,3-dicyano-5,6-dichloro-p-benzoquinone; In 2-methoxy-ethanol; at 120℃; for 24.0h;Sealed tube;	Put 0.1mmol oxidized lignin model substrate 1 in a 10mL pressure tube, add 0.01mmol HNO3, 1mL DMSO and 0.2mmol o-phenylenediamine 2,After tightening the cap, heat the resulting reaction solution (the concentration of oxidized lignin in the reaction solution is 0.1 mmol/mL) in an oil bath at 100C for 12 hours,The decomposition reaction is carried out. After the reaction is completed, the obtained product is taken out and the solvent is drained and separated by a column to obtain two nitrogen-containing heterocyclic products.

References: [1]Patent: CN111454213,2020,A .Location in patent: Paragraph 0129-0136.

30
[ 1741-50-0 ]
C₄₅H₃₁N₅ [ No CAS ]

References: [1]Patent: CN112979616,2021,A .

31
[ 1741-50-0 ]
[ 201802-67-7 ]
C₃₁H₂₃N₃ [ No CAS ]

Yield	Reaction Conditions	Operation in experiment
88%	With tetrakis(triphenylphosphine) palladium(0); potassium carbonate; In toluene; at 100℃;Inert atmosphere;	In a 25 ml round bottom two-necked flask,Add Intermediate 1-1 (1mmol), compound S2 (1mmol), potassium carbonate (1.2mmol), toluene (8ml), water (1ml), tetrakis(triphenylphosphine)palladium (0.05mmol), nitrogen protection After the reaction is completed, it is heated to 100C, quenched by adding water, extracted with dichloromethane, and the organic layer is dried with anhydrous magnesium sulfate, filtered, and spin-dried.The crude product was purified by column chromatography (dichloromethane/n-hexane/methanol (volume ratio 20:10:1)) to obtain Intermediate 2-1 (yield 88%).

References: [1]Patent: CN112979616,2021,A .Location in patent: Paragraph 0131-0133; 0136.

32
1-phenyl-3-hydroxy-2-phenoxy propan-1-one [ No CAS ]
[ 1575-37-7 ]
[ 1741-50-0 ]
[ 4887-88-1 ]
[ 108-95-2 ]

References: [1]European Journal of Organic Chemistry,2022,vol. 2022.

33
[ 721-04-0 ]
[ 1741-50-0 ]

References: [1]European Journal of Organic Chemistry,2022,vol. 2022.

34
[ 70-11-1 ]
[ 1741-50-0 ]

References: [1]European Journal of Organic Chemistry,2022,vol. 2022.

Historical Records

Technical Information

• Alkyl Halide Occurrence • General Reactivity • Grignard Reaction • Hiyama Cross-Coupling Reaction • Kinetics of Alkyl Halides • Kumada Cross-Coupling Reaction • Reactions of Alkyl Halides with Reducing Metals • Reactions of Amines • Reactions of Benzene and Substituted Benzenes • Reactions of Dihalides • Stille Coupling • Substitution and Elimination Reactions of Alkyl Halides • Suzuki Coupling

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[ 1741-50-0 ]

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[ 1741-50-0 ]

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P271	Use only outdoors or in a well-ventilated area.
P272	Contaminated work clothing should not be allowed out of the workplace.
P273	Avoid release to the environment.
P280	Wear protective gloves/protective clothing/eye protection/face protection.
P281	Use personal protective equipment as required.
P282	Wear cold insulating gloves/face shield/eye protection.
P283	Wear fire/flame resistant/retardant clothing.
P284	Wear respiratory protection.
P285	In case of inadequate ventilation wear respiratory protection.
P231 + P232	Handle under inert gas. Protect from moisture.
P235 + P410	Keep cool. Protect from sunlight.
Response
Code	Phrase
P301	IF SWALLOWED:
P304	IF INHALED:
P305	IF IN EYES:
P306	IF ON CLOTHING:
P307	IF exposed:
P308	IF exposed or concerned:
P309	IF exposed or if you feel unwell:
P310	Immediately call a POISON CENTER or doctor/physician.
P311	Call a POISON CENTER or doctor/physician.
P312	Call a POISON CENTER or doctor/physician if you feel unwell.
P313	Get medical advice/attention.
P314	Get medical advice/attention if you feel unwell.
P315	Get immediate medical advice/attention.
P320
P302 + P352	IF ON SKIN: wash with plenty of soap and water.
P321
P322
P330	Rinse mouth.
P331	Do NOT induce vomiting.
P332	IF SKIN irritation occurs:
P333	If skin irritation or rash occurs:
P334	Immerse in cool water/wrap n wet bandages.
P335	Brush off loose particles from skin.
P336	Thaw frosted parts with lukewarm water. Do not rub affected area.
P337	If eye irritation persists:
P338	Remove contact lenses, if present and easy to do. Continue rinsing.
P340	Remove victim to fresh air and keep at rest in a position comfortable for breathing.
P341	If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P342	If experiencing respiratory symptoms:
P350	Gently wash with plenty of soap and water.
P351	Rinse cautiously with water for several minutes.
P352	Wash with plenty of soap and water.
P353	Rinse skin with water/shower.
P360	Rinse immediately contaminated clothing and skin with plenty of water before removing clothes.
P361	Remove/Take off immediately all contaminated clothing.
P362	Take off contaminated clothing and wash before reuse.
P363	Wash contaminated clothing before reuse.
P370	In case of fire:
P371	In case of major fire and large quantities:
P372	Explosion risk in case of fire.
P373	DO NOT fight fire when fire reaches explosives.
P374	Fight fire with normal precautions from a reasonable distance.
P376	Stop leak if safe to do so. Oxidising gases (section 2.4) 1
P377	Leaking gas fire: Do not extinguish, unless leak can be stopped safely.
P378
P380	Evacuate area.
P381	Eliminate all ignition sources if safe to do so.
P390	Absorb spillage to prevent material damage.
P391	Collect spillage. Hazardous to the aquatic environment
P301 + P310	IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P301 + P312	IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P301 + P330 + P331	IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302 + P334	IF ON SKIN: Immerse in cool water/wrap in wet bandages.
P302 + P350	IF ON SKIN: Gently wash with plenty of soap and water.
P303 + P361 + P353	IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P304 + P312	IF INHALED: Call a POISON CENTER or doctor/physician if you feel unwell.
P304 + P340	IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P304 + P341	IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305 + P351 + P338	IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
P306 + P360	IF ON CLOTHING: Rinse Immediately contaminated CLOTHING and SKIN with plenty of water before removing clothes.
P307 + P311	IF exposed: call a POISON CENTER or doctor/physician.
P308 + P313	IF exposed or concerned: Get medical advice/attention.
P309 + P311	IF exposed or if you feel unwell: call a POISON CENTER or doctor/physician.
P332 + P313	IF SKIN irritation occurs: Get medical advice/attention.
P333 + P313	IF SKIN irritation or rash occurs: Get medical advice/attention.
P335 + P334	Brush off loose particles from skin. Immerse in cool water/wrap in wet bandages.
P337 + P313	IF eye irritation persists: Get medical advice/attention.
P342 + P311	IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P370 + P376	In case of fire: Stop leak if safe to Do so.
P370 + P378	In case of fire:
P370 + P380	In case of fire: Evacuate area.
P370 + P380 + P375	In case of fire: Evacuate area. Fight fire remotely due to the risk of explosion.
P371 + P380 + P375	In case of major fire and large quantities: Evacuate area. Fight fire remotely due to the risk of explosion.
Storage
Code	Phrase
P401
P402	Store in a dry place.
P403	Store in a well-ventilated place.
P404	Store in a closed container.
P405	Store locked up.
P406	Store in corrosive resistant/ container with a resistant inner liner.
P407	Maintain air gap between stacks/pallets.
P410	Protect from sunlight.
P411
P412	Do not expose to temperatures exceeding 50 oC/ 122 oF.
P413
P420	Store away from other materials.
P422
P402 + P404	Store in a dry place. Store in a closed container.
P403 + P233	Store in a well-ventilated place. Keep container tightly closed.
P403 + P235	Store in a well-ventilated place. Keep cool.
P410 + P403	Protect from sunlight. Store in a well-ventilated place.
P410 + P412	Protect from sunlight. Do not expose to temperatures exceeding 50 oC/122oF.
P411 + P235	Keep cool.
Disposal
Code	Phrase
P501	Dispose of contents/container to ...
P502	Refer to manufacturer/supplier for information on recovery/recycling

Physical hazards
Code	Phrase
H200	Unstable explosive
H201	Explosive; mass explosion hazard
H202	Explosive; severe projection hazard
H203	Explosive; fire, blast or projection hazard
H204	Fire or projection hazard
H205	May mass explode in fire
H220	Extremely flammable gas
H221	Flammable gas
H222	Extremely flammable aerosol
H223	Flammable aerosol
H224	Extremely flammable liquid and vapour
H225	Highly flammable liquid and vapour
H226	Flammable liquid and vapour
H227	Combustible liquid
H228	Flammable solid
H229	Pressurized container: may burst if heated
H230	May react explosively even in the absence of air
H231	May react explosively even in the absence of air at elevated pressure and/or temperature
H240	Heating may cause an explosion
H241	Heating may cause a fire or explosion
H242	Heating may cause a fire
H250	Catches fire spontaneously if exposed to air
H251	Self-heating; may catch fire
H252	Self-heating in large quantities; may catch fire
H260	In contact with water releases flammable gases which may ignite spontaneously
H261	In contact with water releases flammable gas
H270	May cause or intensify fire; oxidizer
H271	May cause fire or explosion; strong oxidizer
H272	May intensify fire; oxidizer
H280	Contains gas under pressure; may explode if heated
H281	Contains refrigerated gas; may cause cryogenic burns or injury
H290	May be corrosive to metals
Health hazards
Code	Phrase
H300	Fatal if swallowed
H301	Toxic if swallowed
H302	Harmful if swallowed
H303	May be harmful if swallowed
H304	May be fatal if swallowed and enters airways
H305	May be harmful if swallowed and enters airways
H310	Fatal in contact with skin
H311	Toxic in contact with skin
H312	Harmful in contact with skin
H313	May be harmful in contact with skin
H314	Causes severe skin burns and eye damage
H315	Causes skin irritation
H316	Causes mild skin irritation
H317	May cause an allergic skin reaction
H318	Causes serious eye damage
H319	Causes serious eye irritation
H320	Causes eye irritation
H330	Fatal if inhaled
H331	Toxic if inhaled
H332	Harmful if inhaled
H333	May be harmful if inhaled
H334	May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335	May cause respiratory irritation
H336	May cause drowsiness or dizziness
H340	May cause genetic defects
H341	Suspected of causing genetic defects
H350	May cause cancer
H351	Suspected of causing cancer
H360	May damage fertility or the unborn child
H361	Suspected of damaging fertility or the unborn child
H361d	Suspected of damaging the unborn child
H362	May cause harm to breast-fed children
H370	Causes damage to organs
H371	May cause damage to organs
H372	Causes damage to organs through prolonged or repeated exposure
H373	May cause damage to organs through prolonged or repeated exposure
Environmental hazards
Code	Phrase
H400	Very toxic to aquatic life
H401	Toxic to aquatic life
H402	Harmful to aquatic life
H410	Very toxic to aquatic life with long-lasting effects
H411	Toxic to aquatic life with long-lasting effects
H412	Harmful to aquatic life with long-lasting effects
H413	May cause long-lasting harmful effects to aquatic life
H420	Harms public health and the environment by destroying ozone in the upper atmosphere

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Alternative Products

Product Details of [ 1741-50-0 ]

Safety of [ 1741-50-0 ]

Application In Synthesis of [ 1741-50-0 ]

[ 1741-50-0 ] Synthesis Path-Downstream 1~34

Related Products

Historical Records

Technical Information

Categories

Related Functional Groups of [ 1741-50-0 ]

Aryls

Bromides

Related Parent Nucleus of [ 1741-50-0 ]

Benzimidazoles

Precautionary Statements-General

Prevention

Response

Storage

Disposal

Physical hazards

Health hazards

Environmental hazards

Inquiry

Molarity Calculator

Total Compounds Calculator

Dissolution Calculator

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[ 1741-50-0 ]

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[ 1741-50-0 ]