159275-17-9|Benzyl 4-(Bromomethyl)tetrahydro-1(2H)-pyridinecarboxylate| Ambeed

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Quality Control of [ 159275-17-9 ] Purity: 98% SDS Specification

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Product Details of [ 159275-17-9 ]

CAS No. :	159275-17-9
Formula :	C₁₄H₁₈BrNO₂
M.W :	312.20
SMILES Code :	O=C(N1CCC(CBr)CC1)OCC2=CC=CC=C2
MDL No. :	MFCD02681989
InChI Key :	XJHKDSZGAWXUTB-UHFFFAOYSA-N
Pubchem ID :	2776274

Safety of [ 159275-17-9 ]

GHS Pictogram:
Signal Word:	Danger
Hazard Statements:	H314
Precautionary Statements:	P260-P264-P280-P301+P310+P330+P331-P303+P361+P353+P310-P304+P340+P310-P305+P351+P338+P310-P363-P405-P501
Class:	8
UN#:	1759
Packing Group:	Ⅲ

Application In Synthesis of [ 159275-17-9 ]

* All experimental methods are cited from the reference, please refer to the original source for details. We do not guarantee the accuracy of the content in the reference.

Downstream synthetic route of [ 159275-17-9 ]

[ 159275-17-9 ] Synthesis Path-Downstream 1~35

1
[ 89004-82-0 ]
[ 159275-17-9 ]
[ 566905-91-7 ]

References: [1]Journal of Medicinal Chemistry,2003,vol. 46,p. 2606 - 2620.

2
[ 122860-33-7 ]
[ 159275-17-9 ]

Yield	Reaction Conditions	Operation in experiment
10 g	With carbon tetrabromide; triphenylphosphine; In dichloromethane; at 20℃; for 3h;Inert atmosphere;	To a 500 ml three neck round bottomed flask under nitrogen atmosphere, benzyl 4- (hydroxymethyl) piperidine- l-carboxylate (10 g, 40.1 1 mmol) was dissolved in CH2CI2 (100 ml) and cooled to 0 C. Triphenyl phosphine (13.7 g, 52.14 mmol) in CH2CI2 (50 ml) was added to the reaction mixture and stirred at 0 C for 20 minutes. Carbon tetra bromide (16 g, 48.13 mmol) in CH2CI2 (50 ml) was added to reaction mixture which was stirred at rt for 3 h. The reaction mixture was diluted with CH2CI2 and washed with water. Organic layer was dried over sodium sulfate and concentrated under vacuum and purified by column chromatography to give 10 g of benzyl 4-(bromomethyl) piperidine- l-carboxylate.

References: [1]Journal of Medicinal Chemistry,2005,vol. 48,p. 3586 - 3604.
[2]Journal of Medicinal Chemistry,2003,vol. 46,p. 2606 - 2620.
[3]Patent: WO2015/195950,A1 .Location in patent: Page/Page column 82.
Patent: ,2015, .Location in patent: Page/Page column 82.

3
[ 188576-49-0 ]
[ 159275-17-9 ]
[ 247132-98-5 ]

References: [1]Journal of Medicinal Chemistry,2005,vol. 48,p. 3586 - 3604.
[2]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 185 - 189.

4
[ 159275-17-9 ]
[ 247132-77-0 ]
[ 247132-78-1 ]

References: [1]Journal of Medicinal Chemistry,2005,vol. 48,p. 3586 - 3604.
[2]Bioorganic and Medicinal Chemistry Letters,2005,vol. 15,p. 185 - 189.

5
[ 10314-98-4 ]
[ 159275-17-9 ]